The Team
  • Researchers

    Yassmine CHEBARO

    Annick DEJAEGERE


    Roland STOTE

  • PhD Students

    Syrine BEJI

    Sandra CHALHOUB

  • Engineers & Technicians

    Laurent BIANCHETTI


Integrated structural Biology

Chemical biophysics of transcriptional signaling

The immense variety of processes that occur in a living organism rely on  molecular interactions between biological molecules and their ligands. Using computational approaches, we study molecular recognition processes, which allow us to characterize the dynamics and interactions of protein-protein, protein-ligand and protein-DNA complexes. We also seek to characterize and understand the mechanisms of large macromolecular complex assembly and to deepen our understanding of the structural and dynamic consequences of these constructs. For example, we are trying to elucidate how molecular signals are transmitted in biomolecular systems. Recent applications focus on the nuclear receptor super family, which are ligand-induced transcription factors that play a role in complex processes such as differentiation, development and homeostasis of the cell. We study the interplay between ligand binding, structural changes and allostery in these receptors. These projects are developed in collaboration with experimental groups of IGBMC and others. These studies provide important information that can be used in rational drug design projects developed at the interface between groups of molecular biology, biophysics and organic synthesis.

Imprimer Envoyer

Université de Strasbourg

IGBMC - CNRS UMR 7104 - Inserm U 1258
1 rue Laurent Fries / BP 10142 / 67404 Illkirch CEDEX / France Tél +33 (0)3 88 65 32 00 / Fax +33 (0)3 88 65 32 01 /