The Team
  • Researchers

    Michel LABOUESSE

    Sophie QUINTIN

  • Post-Doctoral Fellows

    Julien PONTABRY

  • Phd Students

    Gabriella PASTI

  • Engineers & Technicians


Development and stem cells

Forces and signals in tissue morphogenesis

• How do epithelial cells coordinate cell shape changes with their neighbours?
• What are the mechanical forces involved in embryonic growth?
• How does an epithelial cell maintain distinct (apical and basal) membrane surfaces during growth?
• What are the links between the questions outlined above and pathological processes such as wound repair and cancer?

Our organs originate from small clusters of cells shaped as spheres or discs.  Our general goal is to define how such clusters can upon deformation generate a long tube such as the intestine, a branched tube such as the kidney or the lung, or a simple flat layer such as the epidermis.  To deform an object implies to exert some physical constraints; we are thus trying to identify the mechanical forces involved in shaping organs.  In addition, since organs are larger that their primordium, deformations must also be combined with growth; we thus investigate the nature of the biochemical processes involved in such growth.
To address those general issues, we are using the model C. elegans, a simple and powerful model system. We combine molecular genetic analysis (RNAi, genetic screens, biochemistry), modern imaging techniques (fast confocal microscopy, correlative light and electron microscopy), as well as concepts of physics.

Imprimer Envoyer

Université de Strasbourg

IGBMC - CNRS UMR 7104 - Inserm U 964
1 rue Laurent Fries / BP 10142 / 67404 Illkirch CEDEX / France Tél +33 (0)3 88 65 32 00 / Fax +33 (0)3 88 65 32 01 /