The Team
  • Researchers

    Pierre CHAMBON

    Delphine DUTEIL

    Gilles LAVERNY

    Daniel METZGER

  • Post-Doctoral Fellows


    Anna-Isavella RERRA

    Daniela ROVITO

  • PhD Students

    Kamar GHAIBOUR

  • Engineers & Technicians

    Laetitia PAULEN

Functional genomics and cancer

Pathophysiological function of nuclear receptor signaling

The last decade has seen an enormous rise in the interest for nuclear receptors (NRs), because of their central role in the coordination of development and homeostasis, through their ability to transduce hormonal signals into modulation of gene activity. Our main goal is to study, under physiological and pathophysiological conditions in the whole organism, the function and interdependence of signaling pathways that are regulated by various nuclear receptors [e.g. the retinoid X receptors (RXRs), the retinoic acid receptors (RARs), the peroxisome proliferator-activated receptors (PPARs), the vitamin D3 receptor (VDR), the oestrogen receptors (ERs), the androgen receptor (AR) and the glucocorticoid receptor (GR)] in different organs (e.g. skin, lung, intestine, skeletal muscle and reproductive organs). In that respect, we have used our site-directed cell-specific temporally-controlled somatic mutagenesis method, which allows the generation of somatic mutations in the mouse of any given gene, at any chosen time and in any specific cell type. Interestingly, as this genetic tool is also of great value to generate mouse models of human cancers, the knowledge gained from their analyses should contribute to the development of new cancer therapies.

Imprimer Envoyer

Université de Strasbourg

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