From tooth to guts: mechanisms of epithelial renewal and regeneration
Pr Ophir KLEIN
University of California, San Francisco, États-Unis
vendredi 08 septembre 2017 - 11h00
- Auditorium, IGBMC
Invité(e) par Agnès BLOCH-ZUPAN, USIAS fellow
A central challenge facing medicine today is the development of strategies for organ regeneration and repair, and an important next step for regenerative medicine is to understand the mechanisms by which mammals naturally use stem cells to renew and heal tissues. The continuously growing rodent incisor provides a model that allows us to understand how adult stem cells can produce progeny throughout an animal’s life. This system allows for powerful integration of investigations into how stem cells function, how they evolved, and how their behaviors are coordinated across tissues. I will present data from our recent work focusing on development and renewal of the rodent incisor. This organ, like many others such as the skin, gastrointestinal tract, and hematopoietic system, is dependent on the continuous generation of progeny from stem cells that have the capacity to self-renew as well as to give rise to the required differentiated cell types. I will first discuss candidate approaches to the identity and location of the stem cells, as well as unbiased screening techniques that can be used to deconstruct the system. I will then discuss the transcriptional and signaling networks that regulate the stem cells and will introduce evolutionary perspectives on continuously growing teeth. Finally, I will present recent work from our lab examining the response of gastrointestinal epithelial stem cells to injury, and I will conclude with perspectives on how the power of stem cells can be harnessed to treat human disease.