Vascular Patterning: a tale of fate and forces
Pr Holger GERHARDT
Max Delbrück Center for Molecular Medicine, Berlin, Allemagne
vendredi 29 septembre 2017 - 11h00
- Auditorium, IGBMC
Invité(e) par Biologie du développement et cellules souches, Julien VERMOT
How developing vascular networks acquire the right number and balance of arteries, veins and lymphatic vessels to efficiently supply and drain tissues is poorly understood. In zebrafish embryos, the robust and regular 50:50 balance of intersegmental veins and arteries that form along the trunk, with lymphatics forming along each artery, prompts the intriguing question how the organism keeps “count”. Recent studies suggest that veins and lymphatics originating from bipotential endothelial precursors experience deterministic signals, which restrict their fates even before they form the appropriate vascular connections. Notch signaling is important for artery formation, together suggesting that local molecular signals instruct when and where to form vessels of appropriate identity and connectivity. Our recent studies however show that this process is inherently plastic and that vessel identity and connectivity arise as emergent property as endothelial cells respond to changing blood flow. Notch signaling influences the sensitivity of endothelial cells to polarize under flow, linking genetic and hemodynamic regulation to establish a balanced network of arteries, veins and lymphatic vessels.