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Silylated peptides and polymers: Lego blocks for the bottom up assembly of new bioactive materials

Dr Gilles SUBRA
Institut des Biomolécules Max Mousseron (IBMM), France

vendredi 29 septembre 2017 - 10h00 - Salle de réunion 4004, IGBMC
Invité(e) par Wojciech KREZEL

Affording biological properties to a material is one of the challenges the chemists have to tackle, to improve the efficiency of existing devices and also to propose new biomaterials. Most of synthetic approaches to obtain functional materials rely on non-covalent coatings or post-grafting realized by multistep ligation chemistry. In this context, we envisioned a bottom-up strategy to introduce bioactive peptides in polymers or materials. The approach relies on the synthesis of hybrid blocks displaying one or several hydroxysilane groups.[1] The condensation of such moieties proceeds chemoselectively, at room temperature and is compatible with the handling of biomolecules. Interestingly, any type of peptides but also biopolymers and dyes can be silylated and thus can participate to the covalent formation of the material. Grafting on glass, silicone, and silica surfaces was performed [2] [3] but direct synthesis of 3D hybrid materials can be also operated [4]. Comb-like[5] and linear polymers[6], hydrogels[7] were prepared. Several applications will be presented including cell-adhesive hydrogels, antibacterial silicone catheters[, pro-healing dressings [9] and multi-ligands nanoparticules for cancer imaging.

[1] J. Martinez, G. Subra, A. Mehdi, S. Jebors, C. Enjalbal, L. Brunel, F. Fajula, WO2013190148A1

[2] S. Jebors, C. Enjalbal, M. Amblard, A. Mehdi, G. Subra, J. Martinez, J. Mater. Chem. B. 1 (2013) 2921–2925.

[3] S. Jebors, C. Enjalbal, M. Amblard, G. Subra, A. Mehdi, J. Martinez, Tetrahedron. 69 (2013) 7670–7674.

[4] S. Jebors, et al. J. Mater. Chem. B. 1 (2013) 6510–6515.

[5] S. Jebors, et al. J. Pept. Sci. 21 (2015) 243–247.

[6] S. Jebors, et al. Angew. Chem. Int. Ed. 54 (2015) 3778–3782.

[7] C. Echalier, et al. Chem. Mater. 28 (2016) 1261–1265.

[8] C. Echalier, et al. Mater.Today 28 (2017) 1261–1265.

[9] C. Pinese, et al., Materials Today Chemistry (2017), 73–83.

[10] C. Pinese, et al. Adv. Healthcare Mater. (2016), 5, 3067–3073.

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