Implications of transcriptional mechanism for cell decision-making
Dr Jonathan CHUBB
MRC LMCB, Londres, United Kingdom
Monday, February 11th 2019 - 9:30 a.m.
- Auditorium, IGBMC
Hosted by Nacho MOLINA
Gene transcription is discontinuous, occurring in “bursts or “pulses”. Although transcriptions bursts are conserved in all forms of life, from bacteria through to cells in mammalian tissues, the causes and consequences of bursting are unclear. My talk will explore our recent progress in answering these questions. Using live imaging of transcription, together with single cell transcriptomics and molecular genetics, we have addressed the biological implications of discontinuous transcription for symmetry-breaking in populations of cells during development. We have also evaluated the reality of different models for the mechanisms of transcription bursting, using imaging approaches informed by the natural organisation of gene families within genomes.