4 research departments
750 employees
45 nationalities
55 research teams
16 ERC laureates
260 publications per year
24000 m² lab area

Support us through

Fondation universite de Strasbourg

Key figures 2018

8 congresses, workshops and meetings
3 special seminars
0 internal seminars
31 thesis


Quick Links


Quantitative single molecule imaging in living cells and organisms

Dr Christof GEBHARDT
Universität Ulm, Institut für Biophysik, Germany

Friday, July 19th 2019 - 11 a.m. - Auditorium, IGBMC
Hosted by Nacho MOLINA

In a living organism, numerous inanimate biomolecules and their inherently stochastic interactions are precisely orchestrated and organized in space and time, together enabling the enigma of life. By using single molecule fluorescence microscopy we obtain an exceptionally detailed view on life processes in the natural environment of a live cell or embryo. Tracking individual molecules yields quantitative information such as reaction rates, diffusion coefficients, concentrations and bound fractions and the spatial distribution and stoichiometry of cellular structures. Thus, we obtain information necessary for a deep understanding and modeling of life processes.

I will give a short overview over our imaging methodologies and then focus on recent findings regarding the implications of transcription factor - DNA interaction kinetics on the transcription process, the activation of transcription in zebrafish development and the activity of molecular motors in the cell nucleus.

Imprimer Envoyer

Université de Strasbourg

IGBMC - CNRS UMR 7104 - Inserm U 1258
1 rue Laurent Fries / BP 10142 / 67404 Illkirch CEDEX / France Tél +33 (0)3 88 65 32 00 / Fax +33 (0)3 88 65 32 01 / directeur.igbmc@igbmc.fr