Control of Immunemetabolism by the Glucocorticoid Receptor
Pr Jan TUCKERMANN
Director of the Institute of Comparative Molecular Endocrinology (CME), University of Ulm, Germany
Monday, September 30th 2019 - 11 a.m.
- Meeting room 4004, IGBMC
Hosted by Functional genomics and cancer, Daniel METZGER
The glucocorticoid receptor (GR) has pivotal roles in the control of energy metabolism and inflammation. While this was for a long time considered as separated processes, we show now that the GR in macrophages modulate insulin resistance during obesity and that nutrient sensing enzymes mediate GR anti-inflammatory actions in macrophages during acute inflammation and regeneration.
Thus finetuning of immunometabolism by GR in a cell type specific manner can be beneficial to limit inflammation and reduce insulin resistance.