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Genetic aspects of the temporal patterning of cortical neurogenesis

Dr Ludovic TELLEY
University of Lausanne, Switzerland

Wednesday, January 29th 2020 - 11 a.m. - Auditorium, IGBMC
Hosted by Juliette GODIN

Ludovic Telley obtained his PhD in Neurosciences at the University of Montpellier (France), where he studied the cerebellar development in the laboratory of Dr Fabrice Ango at the Institut de Génomique Fonctionnelle (IGF). After his graduation, he started a postdoctoral fellowship at the University of Geneva in the laboratory of Prof. Denis Jabaudon. In the following years, he developed a solid dual expertise in single cells transcriptomics and bioinformatics, including state-of-the-art machine learning approaches. He recently started his research group (February 2018) at the University of Lausanne with the support of an ERC Starter Grant. His research is focused on cerebellar development, particularly in understanding the molecular programs that control cerebellar neuron differentiation, interaction and assembly into functional circuits which serve as a basis for the cerebellar various functions. To address these questions, he is combining single-cells technologies, bioinformatics tools and in vitro/in vivo gain- and loss-of-function strategies.


Selected  publications

Temporal patterning of apical progenitors and their daughter neurons in the developing neocortex

L. Telley, G. Agirman, J. Prados, N. Amberg, S. Fièvre, P. Oberst, G. Bartolini, I. Vitali, C., Cadilhac, S. Hippenmeyer, L. Nguyen, A. Dayer, D. Jabaudon.

Science, 2016, Volume 364, Issue 6440.

Sequential transcriptional waves direct the differentiation of newborn neurons in the mouse neocortex.

Telley L, Govindan S, Prados J, Stevant I,Nef S, Dermitzakis E, Dayer A, Jabaudon D

Science, 2016, Volume 35, Issue 6280, 1143-1446.

A mixed model of neuronal diversity

Telley L, Jabaudon D

Nature, 2018, Volume 555, 452-454, News and Views.


Progenitor Hyperpolarization Regulates the Sequential Generation of Neuronal Subtypes in the Developing Neocortex.

Vitali I, Fièvre S, Telley L, Oberst P, Bariselli S, Frangeul L, Baumann N, McMahon JJ, Klingler E, Bocchi R, Kiss JZ, Bellone C, Silver DL, Jabaudon D.

Cell, 2018, Volume 174, 2018, 1264-1276.

A cross-modal genetic framework for the organization and plasticity of sensory pathways.

FrangeulL, Pouchelon G, Telley L, Lefort S, Lüscher C, Jabaudon D.

Nature, 2016, Volume 538, Issue 7623, 96-98.


Dual Function of NRP1 in Axon Guidance and Subcellular Target Recognition in Cerebellum.

Telley L, Cadilhac C, Cioni JM, Saywell V, Huettl R, Sarrailh-Faivre C, Dayer A, Huber A, Ango F.

Neuron, 2016, Volume 91, Issue 6, 1276-1291.


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