Structural Biology of Gene and Immune Regulation
Pr Dinshaw J. PATEL
Memorial Sloan-Kettering Cancer Center, New York, États-Unis
vendredi 17 juin 2016 - 11h00
- Auditorium, IGBMC
Invité(e) par Bruno KLAHOLZ & Christophe ROMIER
The first part of the lecture will outline our recent structure-function studies on riboswitches that target anions, amino acids, alarmones and cyclic dinucleoties and also on nucleolytic self-cleaving twister and pistol ribozymes (collaboration on ribozymes with Ronald Micura lab in Innsbruck, Austria).
The second part of the lecture will outline our research on the sensor cGAS – adaptor STING pathway mediated by 2’,3’-cGAMP that is activated on sensing dsDNA in the cytoplasm of metazoans. Progress will also be reported on small molecules that target the binding pockets of cGAS and homodimeric STING, thereby impacting on the interferon response (collaboration on drug screening with Thomas Tuschl lab, Rockefeller University).