Regulation of organismal metabolism by T cells
Pr Diane MATHIS
Harvard Medical School, Division of Immunobiology, Dept. Microbiology & Immunobiology, BOSTON - USA, États-Unis
lundi 13 novembre 2017 - 11h00
- Auditorium, IGBMC
Invité(e) par Susan CHAN
The immune system is responsible for defending an organism against the myriad of microbial invaders it constantly confronts. Over the past several years, it has become increasingly clear that immune system cells also carry out a second major function: the maintenance of organismal homeostasis. Regulatory T cells (Tregs) are important contributors to both of these critical activities, defense being the primary purview of Tregs circulating through lymphoid organs, and homeostasis assured mainly by their counterparts residing in parenchymal tissues. A paradigmatic tissue-Treg population is that found in visceral adipose tissue. VAT Tregs are highly represented in the local CD4+ T cell compartment, have a distinct transcriptome, and display a clonally expanded T cell receptor (TCR) repertoire. They are important regulators of local and systemic inflammation and metabolism. We will address: what cellular and molecular factors control VAT-Treg accumulation? when and where is the unique VAT Treg phenotype diversified? what transcription factors and chromatin elements specify VAT Tregs and, more generally, parenchymal tissue Tregs?