Un des tout premiers centres de recherche européens en biomédecine, l'IGBMC se consacre à l'étude du génome des eucaryotes supérieurs et au contrôle de l'expression génétique ainsi qu'à l'analyse de la fonction des gènes et protéines. Ces connaissances sont appliquées à l'étude des pathologies humaines comme le cancer et les maladies génétiques.

Post Doc - Equipe B. Klaholz

Reference : Isabelle BILLAS (billas@igbmc.fr)

Project: Structural studies of nuclear receptor associated transcriptional complexes in the group of Dr. Bruno Klaholz



The candidate will use crystallography and cryo EM structural methods to solve the structure of the full complex or domains thereof. Background and training in cryo EM will be provided if necessary. The research fellow will benefit from access to the Structural Biology and Genomics platform at IGBMC (cloning, purification, crystallization). IGBMC is equipped with state-of-the-art instruments for crystallography (Eiger detector) and electron microscopy (Titan Krios microscope). Candidates must have a Ph.D. degree, a keen interest in structural biology, and should enjoy working as part of an interdisciplinary team.  They should have a background in at least one of the following areas: molecular biology; biochemistry, in particular protein expression and purification; biophysical characterization of protein-DNA complexes; cryo EM and/or crystallography


Profile: The project aims at unveiling the architecture of the transcriptional complexes based on steroid nuclear receptors with a combined structural and functional approach. This project will require the production, characterization and structural investigation of nuclear receptor complexes.

Votre candidature

If you are interested, please send your CV to Isabelle BILLAS (billas@igbmc.fr) before October 31st 2017

Date limite de candidature : 31 octobre 2017