4 research departments
750 employees
45 nationalities
55 research teams
16 ERC laureates
260 publications per year
24000 m² lab area

Support us through

Fondation universite de Strasbourg



Tel. : +33 (0)3 88 65 34 12

Key figures

52 research teams
131 researchers
35 post-doctoral fellows
68 PhD students
121 engineers & technicians
111 administrators & general services 110 ICS employees

Quick Links

Job opportunities

Mechanisms And Therapeutic Targets For Congenital Myopathies

Reference : PhD Jocelyn Laporte

Offer publication : Jan. 24, 2018

Congenital myopathies are severe genetic diseases that are characterized by muscle weakness at birth and the prevalence of specific histological abnormalities on muscle biopsy. These rare diseases are models to study the changes that occur with age, such as sarcopenia and the accumulation of skeletal muscle dysfunction. There is no specific therapy for these myopathies. In the team we concentrate on 2 classes of severe congenital myopathies: centronuclear myopathies linked to defect of muscle maturation and organelle positioning, and tubular aggregate myopathies linked to calcium handling defects.


The PhD project aims to identify the pathological mechanisms leading to these myopathies through molecular, cellular and in vivo approaches. For the cellular approaches we will use in vitro differentiation of cultured myofibers, genome editing and several modes of imaging (timelapse, super-resolution, confocal). To tackle the physiopathology, we will use zebrafish and mice models and modulate the level of the implicated genes by transgenesis (CRISPR/Cas9) and viral transduction (AAV).


The success of this project will expand our understanding of muscle maturation under normal and pathological conditions and potentially identify new therapeutic targets for myopathies.

Your application

Application Deadline : Nov. 1, 2018

Imprimer Envoyer

Université de Strasbourg

IGBMC - CNRS UMR 7104 - Inserm U 1258
1 rue Laurent Fries / BP 10142 / 67404 Illkirch CEDEX / France Tél +33 (0)3 88 65 32 00 / Fax +33 (0)3 88 65 32 01 / directeur.igbmc@igbmc.fr