Reference : IGBMC / POST DOC L.M.
Institut de Genetique et de Biologie Moleculaire et Cellulaire (IGBMC) in Strasbourg, France seeks one postdoctoral researcher to join the Lab of Dr. Mei Li on “Pathogenesis of Inflammatory Disease” (http://www.igbmc.fr/research/department/2/team/127/)
Regulation of T cell immunity in skin inflammatory pathogenesis
The skin is the body's primary barrier against physical insults and microbial pathogens, representing a unique environment in which various immune cells interact with skin cells in physiological and pathological contexts. The lab is interested in deciphering how the dysregulated cytokine signalings derived from epithelial cells coordinate innate and adaptive immune responses in the skin, which are crucially implicated in inflammatory pathogenesis of diseases such as atopic dermatitis and psoriasis. Interestingly, recent studies from the lab also uncovered inflammatory pathways shared by skin cancers.
The objective of the postdoctoral research is to delineate immune pathways through which skin keratinocytes program the immune response in skin microenvironment via their production of cytokines to control the T cell response. One particular interest is on the crosstalk of Th2 and Treg cell responses, which is implicated both in AD and skin tumor cell growth and metastasis, and how such responses are controlled by skin dendritic cells (DCs). The study will integrate mouse models, genetic tools (conditional knockout, reporter, cell-depleting mice), in combination with immunological approaches (flow cytometry, adoptive cell transfer, cell sorting, in vitro cell differentiation), and molecular biology tools including single cell RNA-Seq analyses.
Applicants should have a PhD or equivalent doctoral degree with proven research experience in Molecular Biology and Immunology. Candidates should have a good publication record and should be fluent in English. Good communication skills (oral and written) and the ability to work in a team are essential.
The current position is open from 1st Jan. 2020 for an 18-month contract with salary depending on candidate’s experience, with a potential for an extension.
The Institute of Genetics and Molecular and Cellular Biology (IGBMC), created by Pierre Chambon in 1994, is the largest research unit in France and one of the main European biomedical research centers. The goal of IGBMC is to develop interdisciplinary research at the interface of biology, biochemistry, physics and medicine, and to attract researchers from around the world by offering high-level education in the biomedical sciences. The institute provides access to state-of-the-art infrastructure and platforms, including mouse genetic modification (transgenic and knockout), animal faculties, next-generation sequencing, flow cytometry, imaging, high-throughput screening, etc.
The IGBMC campus, located on the "Parc d'Innovation d'Illkirch" in the Strasbourg suburbs, is an exceptional scientific, academic and industrial environment that favors interdisciplinary collaborations and technology transfer. The working language is English.
Candidate should contact:
Dr. Mei Li
Département de Génomique Fonctionnelle et Cancer
Institut de Génétique et de Biologie Moléculaire et Cellulaire (IGBMC)
CNRS UMR 7104 - Inserm U 1258 – Université de Strasbourg
1, rue Laurent Fries
Tel: +33 3 88 65 35 71