Reference : IGBMC / POST DOC G.M.
Post-doctoral position for single cell analysis to study tumor heterogeneity in renal cell carcinomas
Keywords: Cancer, single cell analysis, 10x genomics, transcriptome, RNA-sequencing
Missions and activity of the recruited scientist: Recent advances in technologies have allowed to perform analyses with unprecedented levels of precision and sensitivity to achieve deep characterization of cancer ecosystem including immune, stromal and cancer cells. Among these methods, single cell RNA-sequencing allows offers a unique opportunity to characterize interactions between cancer cells within the tumour as well as between cancer cells and their environment. These tools should lead to a better understanding of the tumor molecular classification but also to a deep understanding of mechanisms implicated in cancer recurrence and/or resistance to treatments. In this context, we already developed in our laboratory at IGBMC single-cell transcriptome sequencing allowing to analyze primary renal cell carcinomas as well as resistant clones following immune checkpoint inhibitors therapies.
We propose to develop novel single cell approaches to study transcriptomic and epigenetic heterogeneity of various primary subtypes of renal cell carcinomas at different stages. These developments are central to a larger collaborative projects involving urologists, medical oncologists, pathologists, bioinformaticians and basic scientists. These will have major implications for defining cancer ecosystem of various renal cell carcinomas subtypes fostering the development of new anti-cancer agents by harnessing basic science and the translational and clinical resources of the Strasbourg university hospitals.
Candidate profile: The ideal post doc should have a strong experiences in cell biology and strong academic background. A background in immunology and/or single-cell sequencing would be appreciated but it is not required.
Objectives and proposed position: The candidate should achieve the development of robust strategies and protocols to perform single cell transcriptomic analyses of freshly dissociated tumour samples. In addition, he should develop mechanistic studies aiming to validate the single-cell observations in vitro and in vivo. The successful candidate will be offered a 24-month contract with salary depending on candidate’s experience. The objective is to apply for long-term post-doctoral fundings in “Fondation de France”, ARC foundation, “Ligue nationale contre le cancer”, etc.
About IGBMC : The project will be developed at the Institute of Genetics and Molecular and Cellular Biology, an institute focusing on functional genomics. In France, it is the largest research unit, involving the Inserm, CNRS and the University of Strasbourg. In addition to its four scientific programs, the IGBMC has developed advanced scientific services and technological platforms for internal use, but also open to the wider scientific community. The Institute aims to develop interdisciplinary research at the interface of biology, biochemistry, physics and medicine, but also to attract students from around the world by offering very high-level education in the field of biomedical sciences. The IGBMC campus is located on the “Parc d’Innovation d’Illkirch” in the Strasbourg suburbs, which represents an exceptional scientific, academic and industrial environment and largely favors collaborations and technology transfer. The institute provides an exciting, interactive scientific environment and hosts, and has access to well-equipped modern technological platforms.
Candidates should send a curriculum vitae with a publication list, a short summary of research achievements and mastered techniques in English, and the names and email addresses of at least two references to Pr. Gabriel Malouf (email@example.com).