4 research departments
750 employees
45 nationalities
55 research teams
16 ERC laureates
260 publications per year
24000 m² lab area

Support us through

Fondation universite de Strasbourg

photo

Head

Key figures

52 research teams
129 researchers
34 post-doctoral fellows
67 PhD students
120 engineers & technicians
111 administrators & general services 110 ICS employees

Quick Links

Job opportunities

Master Internship

Reference : IGBMC / JL

Offer publication : June 16, 2020

We are looking for a highly motivated student to obtain a Master degree in Life Sciences starting in 2020 or 2021. The Master student has the option to continue with a PhD.

 

The IGBMC is a leading European center for biomedical research and provides superior infrastructures of facilities and platforms. The team of Jocelyn Laporte and Johann Bohm is composed of 20 members with different and complementary expertise (www.igbmc.fr\Laporte). It is an international team and the work language is English. We are interested in the genetics and physiopathology of congenital myopathies, and we aim to develop therapeutic proofs-of-concept. The Master/PhD project addresses tubular aggregate myopathy (TAM) and Stormorken syndrome (STRMK), two clinically overlapping multi-systemic disorders affecting skeletal muscle, platelets, spleen, skin, and the immune system. We discovered that TAM/STRMK is caused by abnormal calcium balance (Böhm et al., AJHG 2013, https://pubmed.ncbi.nlm.nih.gov/23332920/?from_term=b%C3%B6hm+stim1&from_sort=date&from_pos=8), and we recently generated a faithful animal model recapitulating the human disorder (Silva-Rojas et al., HMG 2019, https://pubmed.ncbi.nlm.nih.gov/30576443/?from_term=b%C3%B6hm+stim1&from_sort=date&from_pos=2). We now want to assess the efficacy of different therapeutic approaches, including genetic crossings with other mouse lines, AAV-mediated modulation of calcium homeostasis, and screening of pharmacological compounds.

 

TAM/STRMK cell and animal models are available in the laboratory, and we have established a panel of multi-disciplinary techniques and approaches to investigate the physiology of muscle and other tissues, and to evaluate the efficacy of the different therapeutic approaches. The expected results of the project are of high scientific and medical impact.

Notes

Strasbourg is the capital of the European Union, lies in the heart of the continent, and is a cosmopolitan and animated city. Germany is only a few minutes away by walk, and Paris can be reached within 2 hours by train.

Your application

Please send your application including a motivation letter, CV, certificates, and recommendation letters or references in a single PDF file to jocelyn@igbmc.fr and Johann@igbmc.fr

Imprimer Envoyer

Université de Strasbourg
INSERM
CNRS

IGBMC - CNRS UMR 7104 - Inserm U 1258
1 rue Laurent Fries / BP 10142 / 67404 Illkirch CEDEX / France Tél +33 (0)3 88 65 32 00 / Fax +33 (0)3 88 65 32 01 / directeur.igbmc@igbmc.fr