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Post-Doctoral Position In Rna Molecular Biology, Seraphin Lab

Reference : IGBMC-POD-42

Offer publication : Aug. 9, 2021

The applicant will benefit from a highly collaborative and international environment at IGBMC (>700 researchers, 4 departments, 44 teams). The Séraphin team is a leader in the field of eukaryotic RNA decay, RNA processing and protein complex analyses using mammalian cells and yeast as model systems. IGBMC provides access to state-of-the-art platforms and technical support including imaging, proteomic, high throughput sequencing, cell culture, bioinformatics, and mouse facilities. The project will benefit from technical support and develop in the framework of national and international collaborations. IGBMC is located in the periphery of Strasbourg providing a scientifically and culturally rich and unique environment.

Assignments

Overview: The Séraphin team working on protein complexes involved in RNA decay is hiring a post-doc (24 months with possibility of extension) to work onthe Control of deadenylation and translation by the CCR4-NOT complex

Activity

The importance of mRNA decay in regulating and finely tuning gene expression is now well established. The CCR4-NOT complex is a multi-subunit assembly, present in all eukaryotes, that plays a primordial role in this control. Indeed, this complex works as the major deadenylase that initiates mRNA decay by shortening their poly(A) tails. Further, the CCR4-NOT complex has been shown to link translation efficiency to mRNA decay.

We have recently identified new protein partners of the human CCR4-NOT complex. Interestingly, inactivation of one of the corresponding genes in mice leads to a severe phenotype. Based on our initial observations, the successful candidate will elucidate the functions of the CCR4-NOT complex in relation to its interaction with this new partner. The molecular function of this factor will be investigated using cutting-edge technologies including transcriptome and poly(A)-tail-seq analyses, CRISPR-Cas9 inactivation in cell lines, proteomic and imaging and benefit from parallel study of its impact on mouse development at the institute.

Profile

he importance of mRNA decay in regulating and finely tuning gene expression is now well established. The CCR4-NOT complex is a multi-subunit assembly, present in all eukaryotes, that plays a primordial role in this control. Indeed, this complex works as the major deadenylase that initiates mRNA decay by shortening their poly(A) tails. Further, the CCR4-NOT complex has been shown to link translation efficiency to mRNA decay.

We have recently identified new protein partners of the human CCR4-NOT complex. Interestingly, inactivation of one of the corresponding genes in mice leads to a severe phenotype. Based on our initial observations, the successful candidate will elucidate the functions of the CCR4-NOT complex in relation to its interaction with this new partner. The molecular function of this factor will be investigated using cutting-edge technologies including transcriptome and poly(A)-tail-seq analyses, CRISPR-Cas9 inactivation in cell lines, proteomic and imaging and benefit from parallel study of its impact on mouse development at the institute.

Required skills and abilities

Languages

English: good level

French speaking is NOT a requirement

 

Requirements

PhD in Molecular Biology

Notes

Benefits

Salary based on experience following Institute guidelines

Your application

Please send your application including a statement describing research experience and expertise as well as future research interests, a curriculum vitae with publication list, date of availability, and at least two contacts for references (including phone number and email) to “mauxion(at)igbmc.fr”

Imprimer Envoyer

Université de Strasbourg
INSERM
CNRS

IGBMC - CNRS UMR 7104 - Inserm U 1258
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