The Team
  • Researchers

    Isabelle BILLAS MASSOBRIO

    Bruno KLAHOLZ

    Kundhavai NATCHIAR

    Alexandre OURJOUMTSEV

  • Post-Doctoral Fellows

    Jaime ALEGRIO LOURO

    Brice BEINSTEINER

    Vanessa DACLEU SIEWE

    Clara Ottilie LOEFFELHOLZ VON COLBERG

    Kareem MOHIDEEN ABDUL

    Rachel TABARONI

  • PhD Students

    Léo FRECHIN

    Pierre VILELA

  • Engineers & Technicians

    Leonid ANDRONOV

    Isabelle HAZEMANN

    Jean-François MENETRET

  • Trainee

    Yung-Chieh CHEN

Integrated structural Biology

Large complexes involved in gene expression

Transcription and translation are fundamental molecular mechanisms of gene activity regulation with profound implications for human health. The ligand-dependent transcriptional regulation by nuclear receptors bound to DNA response elements involves the transient assembly of large co-regulator complexes. These trigger chromatin remodeling and facilitate the assembly of the general transcription machinery on the promoter of the target gene. Gene expression is also regulated at the level of protein synthesis, for example, by protein factors that bind to the ribosome during the translation initiation, elongation and termination phase. The initiation phase is strongly regulated by factors and also by the mRNA itself and well-characterized reaction intermediates of the initiating ribosomal nano-machinery are potential targets for antibiotics. Both transcription and translation complexes represent large, transient macromolecular assemblies that we investigate by using an integrative structural biology approach with crystallography and cryo-electron microscopy forming the core.

 

Bruno Klaholz is also scientific coordinator of the Biostructure structural biology research infrastructure, itself selected within the FRISBI project.

 Know more about the cryo electron microscopy facilities

 

Movie: Visualization of modifications in the human ribosome structure, a new feat for cryo electron microscopy

 

 

Imprimer Envoyer

Université de Strasbourg
INSERM
CNRS

IGBMC - CNRS UMR 7104 - Inserm U 1258
1 rue Laurent Fries / BP 10142 / 67404 Illkirch CEDEX / France Tél +33 (0)3 88 65 32 00 / Fax +33 (0)3 88 65 32 01 / directeur.igbmc@igbmc.fr