The Team
  • Researchers

    Manuel MENDOZA

  • Post-Doctoral Fellows

    Mercè GOMAR I ALBA

  • PhD Students

    Monica DAM

    Vasilisa POZHARSKAIA

  • Engineers & Technicians

    Céline ZIEGLER-BIRLING

Development and stem cells

Nuclear organisation and division

Living cells have a fascinating ability to generate complex and dynamic internal structures. Nowhere is this property more evident than during cell division: in only a few minutes, cells alter their shape, duplicate and partition their internal components, and divide into two apparently identical halves, which in many cases go on to acquire distinct identities. These dramatic changes need to be carefully coordinated with each other in space and time.

 

To gain insight into these processes, we focus on two major cell cycle transitions. First, we study how chromosome segregation and cytokinesis are coordinated with each other. In particular, we study how the Aurora-B-dependent “NoCut” checkpoint regulates cytokinesis abscission when chromatin bridges are delayed in the cell division site.

 

Second, we are interested in mechanisms that establish differences in nuclear organization after asymmetric cell division, and in how nuclear pore complexes control the establishment of cell identity.

 

If you are interested in joining the lab, please email directly to Manuel Mendoza mendozam@igbmc.fr

Imprimer Envoyer

Université de Strasbourg
INSERM
CNRS

IGBMC - CNRS UMR 7104 - Inserm U 1258
1 rue Laurent Fries / BP 10142 / 67404 Illkirch CEDEX / France Tél +33 (0)3 88 65 32 00 / Fax +33 (0)3 88 65 32 01 / directeur.igbmc@igbmc.fr