Awards & Publications
Awards:
Pr. Brigitte Kieffer is recipient for:
1994: Junior Membership of the « Institut Universitaire de France ».
2001: Jules Martin Award from the French of Science.
2004: Lounsbery Award from both French and US Academies of Science
Original articles in peer-reviewed journals 2003-2007 :
2003
Gavériaux-Ruff C., Simonin F., Filliol D., Matthes H. W. D. and Kieffer B. L. (2003) Enhanced humoral response in kappa-opioid receptor knockout mice. J. Neuroimmunol. 134, 72-81.
Castané A., Robledo P., Matifas, A. Kieffer, B. L. and Maldonado R. (2003) Cannabinoid withdrawal syndrome is reduced in double mu and delta knockout mice. Eur. J. Neurosci. 17, 155-159.
Martin, M., Matifas A., Maldonado R. and Kieffer B. L. (2003) Acute antinociceptive responses in single and combinatorial opioid receptor knockout mice : distinct mu, delta and kappa tones. Eur. J. Neurosci. 17, 701-708.
Philippe, D., Dubuquoy, L., Cheng, Y., Tran Van Chuoï-Mariot, M., Gaveriaux-Ruff, C., Kieffer B. L. and Desreumaux P. (2003) The MOR: a new target with anti-inflammatory properties for the treatment of colon inflammation. J. Clin. Invest. 111, 1329-1338.
Oakley, S. M., Toth, G., Kieffer, B. L., Borsodi, A. and Kitchen, I. (2003) Altered G protein coupling of delta-opioid receptors in brains of mu-opioid receptor knockout mice. Eur. J. Pharm. 466, 91-98.
Jamot L., Matthes H. W. D., Simonin F., Kieffer B. L. and Roder J. C. (2003)Differential involvement of the mu and kappa opioid receptors in spatial learning. Gene Brain and Behavior 2, 80-92.
Morinville, A., Cahill, C. M., Esdaile, J., Aibak, H., Collier, B., Kieffer, B. L. and Beaudet, A. (2003) Regulation of delta opioid receptor trafficking through mu-opioid receptor stimulation: evidence from mu-opioid receptor knockout mice. J. Neurosci. 23, 4888-4898.
Décaillot, F., Befort K., Filliol, D., Yue, S-Y., Walker, P. and Kieffer B. L. (2003) Opioid receptor random mutagenesis reveals a mechanism for G protein coupled receptor activation. Nature Structural Biology 10, 629-636.
Li Y, Eitan S, Wu J, Evans CJ, Kieffer B, Sun X, Polakiewicz RD (2003). Morphine induces desensitization of insulin receptor signaling. Mol. Cell Biol. 23, 6255-66.
Brillet K., Kieffer B. L. and Massotte. (2003) A double cysteine mutation generates a constitutively active conformation of the mu opioid receptor. BMC Pharmacol 3, 14.
Romberg R., Sarton, E., Teppema L., Matthes H. W. D., Kieffer B. L. and Dahan A. (2003) Comparison of morphine-6-glucuronide and morphine on respiratory depressant and antinociceptive responses in wild-type and mu-opioid receptor deficient mice. Br. J. Anesth. 91, 862-870.
Berrendero F., Mendizabal V., Murtra P., Kieffer B. L. and Maldonado R. (2003) Cannabinoid receptor and WIN55212-2-stimulated [35S]-GTPgammaS binding in the brain of mu-, delta- and kappa-opioid receptor knockout mice Eur. J. Neurosci. 18, 2197-2202.
Lutfy K., Eitan S., Bryant C. D. Yang Y. C., Saliminejad N., Walwyn W., Kieffer, B. L., Takeshima H., Carroll Y., Maidment N. T. and Evans C. J. (2003) Buprenorphine-induced antinociception is mediated by mu-opioid receptors and compromised by concomitant activation of ORL-1 receptors. J. Neurosci. 23, 10331-7.
Chefer V. I., Kieffer B. L. and Shippenberg T. S. (2003) Basal and morphine-evoked dopaminergic neurotransmission in the nucleus accumbens of MOR- and DOR-knockout mice. Eur. J. Neurosci. 18, 1915-22.
2004
Walwyn WM, Keith DE, Wei W, Tan AM, Xie CW, Evans CJ, Kieffer BL, Maidment NT. (2004) Functional coupling, desensitization and internalization of virally expressed mu-opioid receptors in cultured dorsal root ganglion neurons from mu-opioid receptor knockout mice. Neurosci. 123, 111-21.
Garcia-Sevilla J. A., Ferrer-Alcon M., martin M., Kieffer B. L. and Maldonado R.(2004) Neurofilament proteins and cAMP pathway in brains of mu-, delta- and kappa-opioid receptor gene knockout mice: effects of chronic morphine administration. Neuropharmacol. 46, 519-30.
Wang D., Raehal, K.M., Lin, E.T., Lowery, J., Kieffer, B. L., Bilsky, E. J. and Sadée W. (2004) Basal signaling of mu opioid receptor in mouse brain : role in narcotic dependance.J. Pharm. Exp. Ther. 308, 512-20.
Lena I, Matthes H, Kieffer B, Kitchen I.(2004) Quantitative autoradiography of dopamine receptors in the brains of mu-opioid receptor knockout mice. Neurosci Lett. 356, 220-4.
Morinville A., Cahill C., Kieffer B. L., Collier B. and Beaudet A. (2004) Mu Opioid Receptor Knockout Prevents Changes in Delta-Opioid Receptor Trafficking Induced by Chronic Inflammatory Pain. Pain 109, 266-273.
Simonin F., Karcher P., Boeuf J. J-M., Matifas A. and Kieffer B. L. (2004) Identification of a novel family of G-protein coupled receptor associated sorting proteins. J. Neurochem. 89, 766-75.
Scherrer G., Befort K., Contet C., Becker J., Matifas A. and Kieffer B. L. (2004)The delta agonists DPDPE and deltorphin II recruit predominantly mu receptors to produce thermal analgesia: a parallel study of mu, delta and combinatorial opioid receptor knockout mice. Eur. J. Neurosci. 19, 2239-2248.
Gaveriaux-Ruff C, Simonin F, Filliol D, Kieffer B. (2004) Antibody response and allogeneic mixed lymphocyte reaction in mu-, delta-, and kappa-opioid receptor knockout mice. J Neuroimmunol. 2004 147, 121-2.
Gouardères C., Kieffer B. L. and Zajac J.-M. (2004) Opposite alterations of NPFF1 and NPFF2 neuropeptide FF receptor density in the triple MOR/DOR/KOR-opioid receptor knockout mouse brains. J. Chem. Neuroanat. 27, 119-129.
Contet C. S., Matifas A. and Kieffer B. L. (2004) No evidence for G protein-coupled epsilon receptors in triple opioid receptor knockout mouse brain .Eur. J. Pharm. 492, 131-136.
Moles A., Kieffer B. L. and D'Amato F. R. (2004) Deficit in attachment behaviour in mice lacking the µ-opioid-receptor gene Science 304,1983-6.
Chefer V. I., Kieffer B. L. and Shippenberg T. S. (2004) Contrasting effects of MOR and DOR deletion upon the behavioral and neurochemical effects of cocaine. Neurosci. 127, 497-503.
Robledo P., Mendizabal V., Ortuño J., de la Torre R., Kieffer B. L. and Maldonado R. (2004)The rewarding properties of MDMA are preserved in mice lacking mu-opioid receptors. Eur. J. Neurosci. 20, 853-8.
2005
Tryoen-Tóth P., Décaillot F. M., Filliol D., Befort K., Lazarus L. H., Schiller P. W., Schmidhammer H., and Kieffer B. L. (2005) Inverse agonism and neutral antagonism at wild-type and constitutively active mutant delta opioid receptors. J. Pharm. Exp. Ther. 313, 410-421.
Grillet N., Pattyn A., Contet C., Kieffer B.L., Goridis C. and Brunet J. F. (2005) Generation and characterization of Rgs4 mutant mice. Mol. Cell. Biol. 25,4221-8.
Sanders M. J., Kieffer B. L and Fanselow M. S. (2005) Deletion of the mu opioid receptor results in impaired acquisition of pavlovian context fear. Neurobiol. Learn. Mem. 84,33-41.
Kovacs K. M., Szakall I., O'Brien D., Wang R., Vinod Y., Saito M., Kieffer B. L. and Vadasz C. (2005) Decreased oral self-administration of alcohol in kappa opioid receptor knockout mice. Alcohol. Clin. Exp. Res. 29, 730-738.
Ghozland S, Chu K, Kieffer BL, Roberts AJ. (2005) Lack of stimulant and anxiolytic-like effects of ethanol and accelerated development of ethanol dependence in mu-opioid receptor knockout mice. Neuropharmacology. 4, 493-501.
Mas Nieto M, Guen SL, Kieffer BL, Roques BP, Noble F. (2005) Physiological control of emotion-related behaviors by endogenous enkephalins involves essentially the delta opioid receptors. Neuroscience. 135, 305-13.
Tabarin A. C., Diz Chavez Y., Catargi B., Roberts A. J., Parker G. C., Zorrilla E. P., Inoue K., Coscina D. V., Kieffer B. L. and Koob G. F (2005). Resistance to diet-induced obesity in mu-opioid receptor deficient mice: evidence for a thrifty gene Diabetes 54, 3510-6.
Walwyn W. M., Keith Jr D.E., Wei W., Tan A.M., Xie C.W., Beltran L., Evans C.J., Kieffer B.L., Maidment N.T. (2005) Induction of delta opioid receptor function by up-regulation of membrane receptors in mouse primary afferent neurons. Mol Pharmacol. 68,1688-98.
2006
Simonin F., Schmitt M., Laulin J.-P., laboureyras E., Jhamandas J. H., MacTavish D., Matifas A., Mollereau C., Kieffer B. L., Bourguignon J.-J. and Simonnet G (2006). RF9, a potent and selective neuropeptide FF receptor antagonist, prevents opioid-induced tolerance and paradoxical hyperalgesia. Proc. Natl. Acad. Sci USA 103, 466-71.
Galeote L, Kieffer BL, Maldonado R and Berrendero F. Mu-opioid receptors are involved in the tolerance to nicotine antinociceptive effect (2006) J Neurochem. 97, 416-23.
Nadal X, Baños J-E, Kieffer BL and Maldonado R. Neuropathic pain is enhanced in _elta-opioid receptor knockout mice (2006) Eur J Neurosci 23, 830-834.
Merg F., Filliol D., Usynin I., Bazov I., Bark N., Hurd Y.L., Yakovleva T., Kieffer B. L. and Bakalkin G. (2006) Big dynorphin as a putative endogenous ligand for the kappa-opioid receptor J. Neurochem. 97, 292-301.
Snook L. A., Milligan G., Kieffer B. L. and Massotte D. Opioid receptor heterodimerization: insights using receptor-G protein fusions (2006) J. Pharm. Exp. Ther. 318, 683-90.
Contet C., Gavériaux-Ruff C, Matifas A., Caradec C., Champy M.-F. and Kieffer B. L. (2006) Dissociation of analgesic and hormonal responses to forced swim stress using opioid receptor knockout mice Neuropsychopharmacol. 31, 1733-44.
Scherrer G., Tryoen-Tóth P., Filliol D., Matifas A., Laustriat D., Cao Y. Q., Basbaum A. I., Dierich D., Vonesh J.-L., Gavériaux-Ruff C. and Kieffer B. L. Knock-in mice expressing fluorescent delta opioid receptors uncover G protein coupled receptor dynamics in vivo Proc. Natl. Acad. Sci. USA 103, 9691-6.
Walwyn WM, Wei W, Xie CW, Chiu K, Kieffer BL, Evans CJ, Maidment NT (2006) Mu opioid receptor-effector coupling and trafficking in dorsal root ganglia neurons. Neuroscience 142, 493-503.
Bigliardi-Qi M, Gaveriaux-Ruff C, Zhou H, Hell C, Bady P, Rufli T, Kieffer B, Bigliardi P. (2006) Deletion of delta-opioid receptor in mice alters skin differentiation and delays wound healing. Differentiation 74, 174-85.
2007
Garcia-Fuster M. J., Ferrer-Alcon M., Martin M., Kieffer B. L., Maldonado R. and Garcia-Sevilla J. A. (2007) Effects of constitutive deletion of opioid receptors on the basal density of Fas and Fas-associated protein with death domain (Fadd) in the mouse bran Eur. Neuropsychopharmacol. 17, 366-74.
Kang-Park M., Kieffer B. L., Roberts A. J., Siggins G. R. and Moore S. D. (2007) Presynaptic delta opioid receptors regulate ethanol actions in central amygdala J. Pharm. Exp. Ther. 320, 917-25.
Contet C., Dierich A. and Kieffer B. L. (2007) Knock-in mice reveal nonsense-
mediated mRNA decay in the brain Genesis 45, 38-43.
Nagai J., Kurokawa M. Takeshima H., Kieffer B. L. and Ueda H. (2007) Nociceptin (NOP)-deficient mice show memory and learning enhancement in a novel KUROBOX apparatus using stress-free positive cue task. J Pharm Exp Ther 321, 195-201.
Ghate A, Befort K, Becker J, Filliol D, Bole-Feysot C, Jost B, Koch M and Kieffer BL (2007) Identification of novel striatal genes by expression profiling in adult mouse brain. Neurosci. 1182-1192.
Marquez P, Baliram R, Kieffer BL, Lutfy K. (2007) The mu opioid receptor is involved in buprenorphine-induced locomotor stimulation and conditioned place preference.
Neuropharmacology 52, 1336-1341.
Chakass D, Philippe D, Erdual E, Dharancy S, Malapel M, Dubuquoy C, Thuru X, Gay J, Gaveriaux-Ruff C, Dubus P, Mathurin P, Kieffer BL, Desreumaux P, Chamaillard M. (2007) Mu opioid receptor activation prevents acute hepatic inflammation and cell death. Gut 56, 974-981.
Bigliardi-Qi M., Gaveriaux-Ruff C., Pfaltz K., Bady P., Baumann T., Rufli T. , Kieffer B. L. and Bigliardi P. (2007) Deletion of m- and k- opioid receptors in mice changes epidermal hypertrophy, density of peripheral nerve endings and itch behavior. J. Invest Dermatol 127, 1479-1488.
Papaleo F., Kieffer B. L., Tabarin A. and Contarino A. (2007) Decreased motivation to eat in mu opioid receptor deficient mice. Eur. J. Neurosci. 25, 3398-3405.
Benbouzid M, Gavériaux-Ruff C, Yalcin I, Waltisperger E., Tessier L-H, Muller A, Kieffer B L, Freund-Mercier M J, and Barrot M. Tricyclic antidepressants recruit delta-opioid receptors to alleviate chronic neuropathic pain. Biol. Psy. (In press)
David V., Matifas A., Gavello-Baudy S., Decorte L., Kieffer B. L. and Cazala P. Fos imaging reveals a mu opioid receptor-dependent activation of VTA-thalamic pathways during morphine self-administration. Neuropsychopharm (in press).
Contet C., Filliol D., Matifas A. and Kieffer B. L. Morphine analgesic tolerance, locomotor sensitization and physical dependence do not require modification of mu opioid receptor, cdk5 and adenylate cyclase activity. Neuropharm. (in press).
Reiss D., Wichmann J., Tekeshima H., Kieffer B. L. and Ouagazzal A-M. Effect of nociceptin (NOP) agonist Ro64-6198 on reactivity to acute pain in mice : comparison to morphine. Eur. J. Pharmacol. (in press).
2008
Snook L.A.S., Milligan G., Kieffer B. L. and Massotte D. (2008) « Co-expression of mu and delta opioid receptors as receptor-G protein fusons enhances both mu and delta signaling via distinct mechanisms. » Journal of Neurochemistry (in press)
Under revision.
Olmstead C., Ouaggazzal A-M. and Kieffer B. L. Deletion of mu opioid receptors in mice decreases impulsivity. Science (under review).
Pradhan A., Becker J., Scherrer G., Tryoen-Toth P., Filliol D., Matifas A., Massotte D., Gavériaux-Ruff, C and Kieffer B. L. In vivo delta opioid receptor internalization controls behavioral responses to agonists. Nature Neurosci. (under revision).
Goeldner C., Reiss D., Wichmann J., Kieffer B. L. and Ouagazzal A-M. Activation of nociceptin receptor impairs acquisition of fear conditioning through modulation of glutamatergic and cholinergic activity. Beh. Pharmacol. (under revision).
Gavériaux-Ruff C., Karchewski, L., Hever X., Hartmann H., Matifas A., Kieffer B. L. Inflammatory pain is enhanced in delta-opioid receptor knockout mice (under revision).
Goeldner C., Reiss D., Wichmann J., Meziane H., Kieffer B. L. and Ouagazzal A-M. Nociceptin receptor impairs memory via interaction with NMDA receptor-dependent MAPK/ERK signalling in the hippocampus. J Neurosci. (under revision).
Befort K, Ghate A., Becker J., Fillio D.l, Darcq E., Muller J., Lardenois A., Poch O., Thibault C., Dembele D., Matifas A. and Kieffer B. L. Mu opioid receptor activation induces transcriptional plasticity in the extended amygdala. (submitted).
Invited reviews and book chapters 2003-2007:
2003
Kieffer B. L. and Simonin F. (2003) Molecular mechanisms of opioid dependence by using knockout mice in Molecular Biology of Drug Addiction, Ed R. Maldonado, Humana Press, Totowa New Jersey USA, 3-25.
Pintar J and Kieffer B. L. Genetic analysis of the endogenous opioid system in Handbook of Experimental Pharmacology, Transgenic models in Pharmacology 2003. Springer Verlag.
Koob G. F., Roberts A. J., Kieffer B. L., Heyser C. J., Katner S. N., Ciccocioppo R and Weiss F. (2003) Animal models of motivation for drinking in rodents with a focus on opioid neuropharmacology. Recent Dev. Alcohol. 16, 263-281.
2004
Dierich A. and B. Kieffer. (2004) Knockout mouse models in pain research. In Methods in Molecular Medicine, Pain research: methods and protocols, Ed. Z. D. Luo, Humana press (Totowa, New Jersey), 269-299.
Décaillot, F. and Kieffer B. L. (2004) In vitro and in vivo mutagenesis : insights into delta receptor structure and function. In The delta receptor, Ed. K-J. Chang, F. Porreca, J. H. Woods, Marcel Dekker, Inc. (New York, Basel), 41-60.
Contet C. S, Kieffer B. L. and Befort K. (2004) Mu opioid receptor: a gateway to drug addiction. Curr. Op. Neurobiol. 14, 1-9.
2005
Massotte D and Kieffer B. L. (2005) Structure-function relationships in G protein-coupled receptors: ligand binding and receptor activation. In G Protein Coupled Receptors Handbook, Ed Devi, L. Contemporary Clinical Neuroscience, Humana Press, Totowa New Jersey USA.
Dickenson T. H and Kieffer B. L. (2005) Opiates-Basic Chap 27 in Wall & Melzack's Textbook of Pain 5th , Ed McMahon and Koltzenburg. Elsevier London UK.
Massotte D. and Kieffer B. L. (2005) The second extracellular loop: a damper for G protein coupled receptors? Nature Structural Biology 12, 287.
2007
Gavériaux-Ruff C. and Kieffer B. L. (2007) Conditional gene targeting in the mouse nervous system: insights into brain function and diseases. Pharm. Ther. 113(3):619-34.
2008
Kieffer, B. L. Opioid peptides and receptors.The New Encyclopedia of Neuroscience, edited by Larry Squire et al, Elsevier, 2008 (in press).
Medias 2003-2007:
Kieffer B. L. Endogenous opioids and addiction. (2003) World Health Organization. Neuroscience Report on drug abuse.
Kieffer B. L. Contribution to a TV documentary -ARTE entitled “Drugs and the brain”. 10-14 oct 2005. Published by S. Horel and J P Lentin, ed Actuel/Panama 2005.
Invited Conferences 2003-2007:
2003
-Duke University, Pr. D. Schwinn, February 4 (Durham, NC, USA)
-Temple University, Pr. M. Adler, February 7 (Philadelphia, USA)
-Laboratoire de Génétique Moléculaire, la Pitié-Salpétrière, Pr. J. Mallet, June 18 (Paris, France).
-British Pharmacological Society, June 27 (Surrey, UK)
-International Narcotic Research Conference July 6-11 (Perpignan, France):
Complete organization
-NIDA Frontiers in Addiction Research, Nov 7 (New Orleans, USA)
2004
-Pfizer, january 13 (Sandwich, Kent, UK)
-Neuropharmacology Course, Biomedicum Center, March 17 (Helsinki, Finland)
-London Pain Consortium, Steering Committee, UCL, March 26 (London, UK)
-European Opioid Conference, Chairman, April 5-5 (Budapest, Hungary).
-International Narcotic Research Conference July 17-23 (Kyoto, Japan)
-Roche, August 13 (Palo Alto, USA).
-European College of neuropsychopharmacology, oct 9-13 (Stockholm, Sweden)
-6th Europad Conference, Nov 1-3 (Paris, France)
2005
-Société des neurosciences, Plenary Lecture, may 17-20 (Lille, France).
-McGill University, June 4th (Montréal, Canada).
-International Narcotic Research Conference July 12-19 (Anapolis, USA)
-Institut de Pharmacologie, Sophia-Antipolis Dec 9 (Nice, France).
2006
-Ecole de l'INSERM, Feb 9 (Paris, France).
-Faculté de Médecine, La Pitié-Salpétrière, Feb 20 (Paris, France).
-University of Nagasaki, march 1 (Nagasaki, Japan).
-Hoshi University, march 4 (Tokyo, Japan).
-RIKEN Brain research Institute, march 6 (Tokyo, Japan).
-Intitute of Psychiatry of Tokyo, march 8 (Tokyo, Japan).
-Académies Sciences de la Vie et Santé, march 30 (Paris, France).
-Journées Institut Universitaire de France 2006, march 30 (Strasbourg, France).
-University of Minnesota, Pr. PY Law, April 29 (Minneapolis, USA).
-Rockefeler University, Pr. MJ Kreek, May 2 (New York, USA).
-Columbia University, Pr. R. Hen, May 4 (New York, USA).
-Mont Sinai School of Medicine, Pr. L. Devi, May 5 (New York, USA).
-15th World Congress of Pharmacology, july 2-7 (Beijing, China).
- Shanghai Institutes for Biological Sciences, Chinese Academy of Sciences, july 18 (Shanghai, China)
-Lemanic Neuroscience Meeting, September 8-9 (Les diablerets, Switzerland)
-Glaxo Smith Kline, September 20 (Verona, Italy).
-Collège de France, November 21 (Paris, France).
2007
-Centre Intégratif de Génomique, January 22 (Lausanne, France).
-European Winter Brain Conference, march 12-16 (Villard, Switzerland)
-Friedrich Miescher Institute, june 7 (Basel, Switzerland).
-Rockefeler University, june 22 (New York, USA)
-Cold Spring Harbor, june 23-28 (Cold Spring harbor, USA)
-Cold Spring Harbor, august 6-12 (Cold Spring harbor, USA)
-32th Conference Hormones and Cell Regulation, 14-16 sept (Mont St Odile, France)
-20th ECNP, oct 13-17 (Vienna, Austria)
-UCSF, Pr. A. Basbaum, nov 19 (San Francisco, USA)
-Gallo Institute, Pr. R. Messing, nov 20 (San Francisco, USA)
2008 Planned
-International Conference Alcoholism and Stress, May 6-8 (Pisa, Italy)
-Keystone symposium G Protein-Coupled Receptors, May 18-23 (Killarney, Ireland)
-33rd FEBS Congress, 28 june-3 july (Athens, Greece)
-FENS 2008, 12-16 july (Geneva, Switzerland)
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