IGBMC : Institut de la Génétique et de la Biologie Moléculaire et Cellulaire

• Researchers

  Stéphane VIVILLE

• Post-Doctoral Fellowships

  Mayada ACHOUR JREDA

  Marius TELETIN

• Phd Students

  Elias ELINATI

  Laura JUNG

  Yara TARABAY

• Engineers & Technicians

  Cécile ANDRE

  Valérie SKORY

  Adeline TOSCH

  Philippe TROPEL

• Master Students

  Joëlle MAKARIAN

Development & stems cells

Primordial germ cells' (PGC) ontogeny and pluripotency

Primordial germ cells (PGC) represent a unique class of cells. They are the embryonic precursors of the gametes, ensuring propagation of the gene pool to the next generation and the continuation and evolution of the species. Our main focus is to decipher the molecular mechanisms that account for maintenance of their toti/pluripotency. Indeed, PGC's can be considered as totipotent cells since following fertilization they can generate all cell types and yield a fully functional organism. Accordingly, most if not all, pluripotent genes are expressed by PGCs. Our goal is to identify actors involved in the process of the PGC's ontogeny, to study their physiological functions and to challenge them as pluripotency reprogramming factors. We also study the genetics of infertility in humans. Specifically, we aim to identify genes affecting human gametogenesis and therefore potentially being involved on the PGC's ontogeny. Based on our expertise in mouse and human embryonic stem (ES) cells, we have set up a new platform dedicated to the production of pluripotent stem cells, such as ES or induced pluripotent stem (iPS) cells. This is done in parallel with the creation of a Biobank of human somatic cells that serve as pathological models.

• Current projects

• Collaborations

• Prizes/Awards

• News

  • April 15, 2012 - New roles of Histone H1 in transcription
  • March 11, 2011 - One of the genetic causes of globozoospermia has just been revealed

• Publications

  • Assisted reproduction treatment and epigenetic inheritance.

    van Montfoort AP, Hanssen LL, de Sutter P, Viville S, Geraedts JP, de Boer P.

    Hum Reprod Update Jan. 19, 2012 .

  • A Recurrent Deletion of DPY19L2 Causes Infertility in Man by Blocking Sperm Head Elongation and Acrosome Formation

    Harbuz R., Zouari R., Pierre V., Ben Khelifa M., Kharouf M., Coutton C., Merdassi G., Abada F., Escoffier J., Nikas Y., Vialard F., Koscinski I., Triki C., Sermondade N., Schweitzer T., Zhioua A., Zhioua F., Latrous H., Halouani L., Ouafi M., Makni M., Jouk P.S., Sele B., Hennebicq S., Satre V., Viville S., Arnoult C., Lunardi J., Ray P.F.

    Am J Hum Genet March 11, 2011 ; 88:351-61 .

  • Autism, imprinting and epigenetic disorders: a metabolic syndrome linked to anomalies in homocysteine recycling starting in early life??

    Ménézo Y, Mares P, Cohen M, Brack M, Viville S, Elder K.

    J Assist Reprod Genet Nov. 3, 2011 .

  • DPY19L2 Deletion as a Major Cause of Globozoospermia

    Koscinski I., Elinati E., Fossard C., Redin C., Muller J., Velez de la Calle J., Schmitt F., Ben Khelifa M., Ray P., Kilani Z., Barratt C.L., Viville S.

    Am J Hum Genet March 11, 2011 ; 88:344-50 .

  • Extended passaging increases the efficiency of neural differentiation from induced pluripotent stem cells

    Koehler K.R., Tropel P., Theile J.W., Kondo T., Cummins T.R., Viville S., Hashino E.

    BMC Neurosci 2011 ; 12:82 .

  • Preimplantation genetic diagnosis (PGD) for Huntington's disease: the experience of three European centres.

    Van Rij MC, De Rademaeker M, Moutou C, Dreesen JC, De Rycke M, Liebaers I, Geraedts JP, De Die-Smulders CE, Viville S.

    Eur J Hum Genet Nov. 9, 2011 .

  • High-efficiency derivation of human embryonic stem cell lines following pre-implantation genetic diagnosis

    Tropel P., Tournois J., Come J., Varela C., Moutou C., Fragner P., Cailleret M., Laabi Y., Peschanski M., Viville S.

    In Vitro Cell Dev Biol Anim Apr 2010 ; 46:376-85 .

  • Red blood cell generation from human induced pluripotent stem cells: perspectives for transfusion medicine

    Lapillonne H., Kobari L., Mazurier C., Tropel P., Giarratana M.C., Zanella-Cleon I., Kiger L., Wattenhofer-Donze M., Puccio H., Hebert N., Francina A., Andreu G., Viville S., Douay L.

    Haematologica Oct 2010 ; 95:1651-9 .

  • [An overview of pluripotent stem cell lines.]

    Kieffer E., Kuntz S., Viville S.

    Med Sci (Paris) Oct 2010 ; 26:848-854 .

  • Creation of a registry for human embryonic stem cells carrying an inherited defect: joint collaboration between ESHRE and hESCreg

    Sermon K.D., Simon C., Braude P., Viville S., Borstlap J., Veiga A.

    Hum Reprod Jul 2009 ; 24:1556-60 .

  See all publications=>

• Job opportunities

  • Post-Doc - Equipe S.Viville (H/F)