IGBMC : Institut de la Génétique et de la Biologie Moléculaire et Cellulaire

• Researchers

  Lasse Bohl JENNER

  Marat YUSUPOV

  Gulnara YUSUPOVA

• Post-Doctoral Fellowships

  Adam BEN SHEM

  Natalia DEMESHKINA

  Sergey MELNIKOV

  Simone PELLEGRINO

• Phd Students

  Nicolas GARREAU DE LOUBRESSE

  Iskander KHUSAINOV

• Engineers & Technicians

  Sylvie DUCLAUD

• Collaborateur Occasionnel

  Liudmila FILONAVA

Integrated structural Biology

Ribosomes

The ribosome is a large ribo-nucleoprotein complex with total molecular mass of 2 500 000 Dalton in bacteria and 3 300 000 Dalton in yeast. Several components contribute to the greater weight and complexity of eukaryotic ribosomes: RNA expansion segments that are inserted into the evolutionary conserved rRNA core and additional 25 proteins. The ribosome performs protein synthesis using a messenger RNA template. It mediates the interactions between mRNAs and tRNAs and it catalyses the peptide bond formation. Our group has developed methods for x-ray study of bacterial 70S ribosome from the extreme thermophilic microorganism Thermus thermophilus and recently for the 80S ribosome from the yeast Saccharomyces cerevisiae. The goal of our group is to study structure and mechanism of protein biosynthesis in bacteria, yeast and humans.

• Current projects

  1. Mechanism of protein biosynthesis based on crystal structure determination of the ribosome functional complexes.
  2. Structure determination of the yeast ribosome and its complexes.
  3. Structure determination of the human ribosome and its complexes.

• Collaborations

  - Dr. Pascale Romby,  Institut de biologie moléculaire et cellulaire du CNRS, Strasbourg, France
  - Prof. Eric Westhof,  Institut de biologie moléculaire et cellulaire du CNRS, Strasbourg, France
  - Prof. Ermanno Candolfi , Institut de parasitologie-mycologie et pathologie tropicale, Faculté de médecine de Strasbourg, France
  - Dr.  Yves Mechulam, L'École Polytechnique,  Biology depart,  Palaiseau, France
  - Prof. Christian Spahn, Charité - Universitätsmedizin Berlin, Germany
  - Prof. Marina Rodnina,  Max Planck Institute for Biophysical Chemistry, Göttingen, Germany
  - Dr. Daniel Wilson , Gene Center Munich, Department of Biochemistry, Munich, Germany
  - Prof. Roland Beckmann, Gene Center Munich, Department of Biochemistry, Munich, Germany
  Dr. Karissa Sanbonmatsu , Los Alamos National Laboratory
  Theoretical Division, USA
  - Prof. Tatyana Pestova,  Department of Cell Biology, SUNY Downstate Medical Center, Brooklyn, NY, USA.
  - Dr. Thomas E. Dever, Section on Protein Biosynthesis, Laboratory of Eukaryotic Gene Regulation, National Institute of Child Health and Human Development, National Institutes of Health, Bethesda, MD, USA

• Prizes/Awards

  • Marat YUSUPOV - Gregori Aminoff Prize - Académie royale suédoise des sciences - 2012
  • Gulnara YUSUPOVA - Gregori Aminoff Prize - Académie royale suédoise des sciences - 2012
  • Marat YUSUPOV - Emile Jungfleisch Prize - Institut de France de l'Académie des Sciences - 2011
  • Marat YUSUPOV - ERC Advanced grant - European Research Council (ERC) - 2011
  • Marat YUSUPOV - Member of the European Molecular Biology Organization (EMBO) - European Molecular Biology Organization (EMBO) - 2009
  • Gulnara YUSUPOVA and Marat YUSUPOV - Newcomb Cleveland prize - The American Association for the Advancement of Science - 2001

• News

  • April 16, 2012 - Two IGBMC researchers awarded by HFSP
  • March 31, 2012 - Aminoff prize 2012
  • March 21, 2012 - Decoding life: the underside of ribosome
  • Jan. 24, 2012 - IGBMC, an institute of excellence awarded by the European research council (ERC)
  • Nov. 17, 2011 - High-resolution ribosome
  • Nov. 25, 2010 - Crystal structure of the eucaryotic ribosome

• Publications

  • A new understanding of the decoding principle on the ribosome.

    Demeshkina N, Jenner L, Westhof E, Yusupov M, Yusupova G.

    Nature March 21, 2012 .

  • The Structure of the Eukaryotic Ribosome at 3.0 A Resolution.

    Ben-Shem A, Garreau de Loubresse N, Melnikov S, Jenner L, Yusupova G, Yusupov M.

    Science Nov. 17, 2011 .

  • Crystal structure of the eukaryotic ribosome

    Ben-Shem A., Jenner L., Yusupova G., Yusupov M.

    Science Nov. 26, 2010 ; 330:1203-9 .

  • Interactions of the ribosome with mRNA and tRNA

    Demeshkina N., Jenner L., Yusupova G., Yusupov M.

    Curr Opin Struct Biol Jun 2010 ; 20:325-32 .

  • Isolation and crystallization of a chimeric Qbeta replicase containing Thermus thermophilus EF-Ts

    Vasiliev N.N., Jenner L., Yusupov M.M., Chetverin A.B.

    Biochemistry (Mosc) Aug 2010 ; 75:989-94 .

  • Structural aspects of messenger RNA reading frame maintenance by the ribosome

    Jenner L.B., Demeshkina N., Yusupova G., Yusupov M.

    Nat Struct Mol Biol May 2010 ; 17:555-60 .

  • Structural rearrangements of the ribosome at the tRNA proofreading step

    Jenner L., Demeshkina N., Yusupova G., Yusupov M.

    Nat Struct Mol Biol Sep 2010 ; 17:1072-8 .

  • A structural view of translation initiation in bacteria

    Simonetti A., Marzi S., Jenner L., Myasnikov A., Romby P., Yusupova G., Klaholz B.P., Yusupov M.

    Cell Mol Life Sci Feb 2009 ; 66:423-36 .

  • Ribosomal initiation complexes probed by toeprinting and effect of trans-acting translational regulators in bacteria

    Fechter P., Chevalier C., Yusupova G., Yusupov M., Romby P., Marzi S.

    Methods Mol Biol 2009 ; 540:247-63 .

  • Ribosomal position and contacts of mRNA in eukaryotic translation initiation complexes

    Pisarev A.V., Kolupaeva V.G., Yusupov M.M., Hellen C.U., Pestova T.V.

    Embo J June 4, 2008 ; 27:1609-21 .

  See all publications=>

• Job opportunities

  • Phd - Equipe M.Yusupov (H/F)