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A Small Compound Targeting Prohibitin with Potential Interest for Cognitive Deficit Rescue in Aging mice and Tau Pathology Treatment.
Guyot AC(1), Leuxe C(1), Disdier C(1)(2), Oumata N(3), Costa N(1), Roux GL(1), Fernandez-Varela P(4), Duchon A(5), Charbonnier JB(4), Herault Y(5), Pavoni S(6), Galons H(3), Andriambeloson E(7), Wagner S(7), Meijer L(8), Lund AK(9), Mabondzo A(10).
Sci Rep Jan. 24, 2020
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High-throughput discovery of genetic determinants of circadian misalignment.
Zhang T(1), Xie P(1), Dong Y(1), Liu Z(1), Zhou F(1), Pan D(1), Huang Z(1), Zhai Q(1), Gu Y(1), Wu Q(2)(3), Tanaka N(4), Obata Y(4), Bradley A(5), Lelliott CJ(5); Sanger Institute Mouse Genetics Project, Nutter LMJ(6), McKerlie C(6), Flenniken AM(6), Champy MF(7), Sorg T(7), Herault Y(7), Angelis MH(8)(9), Durner VG(8), Mallon AM(10), Brown SDM(10), Meehan T(11), Parkinson HE(11), Smedley D(12), Lloyd KCK(13), Yan J(14), Gao X(14), Seong JK(15), Wang CL(16), Sedlacek R(9), Liu Y(17), Rozman J(8)(9)(18), Yang L(1), Xu Y(1)(3).
PLoS Genet Jan. 13, 2020
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Human and mouse essentiality screens as a resource for disease gene discovery.
Cacheiro P(1), Muñoz-Fuentes V(2), Murray SA(3), Dickinson ME(4)(5), Bucan M(6), Nutter LMJ(7), Peterson KA(3), Haselimashhadi H(2), Flenniken AM(8), Morgan H(9), Westerberg H(9), Konopka T(1), Hsu CW(4), Christiansen A(4), Lanza DG(5), Beaudet AL(5), Heaney JD(5), Fuchs H(10), Gailus-Durner V(10), Sorg T(11), Prochazka J(12), Novosadova V(12), Lelliott CJ(13), Wardle-Jones H(13), Wells S(9), Teboul L(9), Cater H(9), Stewart M(9), Hough T(9), Wurst W(14)(15)(16), Sedlacek R(12), Adams DJ(13), Seavitt JR(5), Tocchini-Valentini G(17), Mammano F(17), Braun RE(3), McKerlie C(7)(18), Herault Y(19), de Angelis MH(10)(20)(21), Mallon AM(9), Lloyd KCK(22), Brown SDM(9), Parkinson H(2), Meehan TF(2), Smedley D(23); Genomics England Research Consortium; International Mouse Phenotyping Consortium.
Nat Commun Jan. 31, 2020
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Modeling Down syndrome in animals from the early stage to the 4.0 models and next.
Muñiz Moreno MDM(1), Brault V(1), Birling MC(2), Pavlovic G(2), Herault Y(3).
Prog Brain Res 2020
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The Deep Genome Project.
Lloyd KCK(1), Adams DJ(2), Baynam G(3)(4)(5), Beaudet AL(6), Bosch F(7), Boycott KM(8), Braun RE(9), Caulfield M(10), Cohn R(11), Dickinson ME(6)(12), Dobbie MS(13), Flenniken AM(14), Flicek P(15), Galande S(16), Gao X(17), Grobler A(18), Heaney JD(6), Herault Y(19), de Angelis MH(20)(21)(22), Lupski JR(6), Lyonnet S(23), Mallon AM(24), Mammano F(25), MacRae CA(26), McInnes R(27), McKerlie C(11)(28), Meehan TF(15), Murray SA(9), Nutter LMJ(28), Obata Y(29), Parkinson H(16), Pepper MS(30), Sedlacek R(31), Seong JK(32), Shiroishi T(29), Smedley D(33), Tocchini-Valentini G(25), Valle D(34), Wang CL(35), Wells S(24), White J(9), Wurst W(36)(37)(38), Xu Y(39), Brown SDM(40).
Genome Biol Feb. 3, 2020
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Amphiphysin 2 modulation rescues myotubular myopathy and prevents focal adhesion defects in mice.
Lionello VM(1)(2)(3)(4), Nicot AS(1)(2)(3)(4)(5)(6), Sartori M(1)(2)(3)(4), Kretz C(1)(2)(3)(4), Kessler P(1)(2)(3)(4), Buono S(1)(2)(3)(4), Djerroud S(1)(2)(3)(4), Messaddeq N(1)(2)(3)(4), Koebel P(1)(2)(3)(4), Prokic I(1)(2)(3)(4), Herault Y(1)(2)(3)(4), Romero NB(7)(8)(9), Laporte J(10)(2)(3)(4), Cowling BS(1)(2)(3)(4).
Sci Transl Med March 20, 2019
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BIN1 recovers tauopathy-induced long-term memory deficits in mice and interacts with Tau through Thr348 phosphorylation.
Sartori M(1)(2)(3)(4), Mendes T(5)(6)(7)(8), Desai S(5)(6)(7), Lasorsa A(7)(9), Herledan A(6)(10)(11), Malmanche N(5)(6)(7), Makinen P(12), Marttinen M(12), Malki I(7)(9), Chapuis J(5)(6)(7), Flaig A(5)(6)(7), Vreulx AC(5)(6)(7), Ciancia M(1)(2)(3)(4), Amouyel P(5)(6)(7), Leroux F(6)(10)(11), Deprez B(6)(10)(11), Cantrelle FX(7)(9), Marechal D(1)(2)(3)(4), Pradier L(8), Hiltunen M(12), Landrieu I(7)(9), Kilinc D(5)(6)(7), Herault Y(13)(14)(15)(16), Laporte J(17)(18)(19)(20), Lambert JC(21)(22)(23).
Acta Neuropathol May 7, 2019
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Cbs overdosage is necessary and sufficient to induce cognitive phenotypes in mouse models of Down syndrome and interacts genetically with Dyrk1a.
Marechal D(1)(2)(3)(4), Brault V(1)(2)(3)(4), Leon A(5), Martin D(1)(2)(3)(4), Pereira PL(6), Loaec N(5), Birling MC(7), Friocourt G(5), Blondel M(5), Herault Y(1)(2)(3)(4)(7).
Hum Mol Genet May 1, 2019
