The Team
  • Researchers

    Maria Elena TORRES PADILLA

  • Engineers & Technicians

    Céline ZIEGLER-BIRLING

Development and stem cells

Epigenetics and cell fate in early mammalian development

Research in our group focuses on understanding how early mouse development is regulated by chromatin-mediated changes in gene regulation, that is, by epigenetic information. In particular, we are interested in understanding how the transitions in cell potency and cell fate are regulated by chromatin-mediated processes. We use the mouse embryo as a model because this is one of the few systems where it is possible to explore the foundations of totipotency and differentiation. Indeed, the zygote, which is the product of fertilization of an oocyte by sperm, has an inherent capacity to form all cell types in an organism. Chromatin-mediated changes in gene regulation have to ensure the plasticity required for undertaking such an essential task during development.Our projects will help us to understand how chromatin structure is progressively modified to restrict cell fate determination with the consequent loss of totipotency. Our work will also allow new insights in understanding the biology of the pluripotent stem cells, in particular on their origin and development. From a broader perspective, deciphering the basic mechanisms underlying the earliest steps of mammalian development is essential to understand early aspects of embryonic development, human reproduction and stem cell biology.

 

ERC stories : An international career to push the frontiers of epigenetics (November 2015)


Our lab is member of the FP7
Network Nucleosome4D (http://www.nucleosome4d.net/) and
EpiGeneSys NoE (http://www.epigenesys.eu/)

 

Our lab is part of the ‘Cellular signaling and nuclear dynamics’ programme”

 

If you are interested in joining the lab, please email directly to Maria-Elena Torres-Padilla metp@igbmc.fr

Team website

Imprimer Envoyer

Université de Strasbourg
INSERM
CNRS

IGBMC - CNRS UMR 7104 - Inserm U 964
1 rue Laurent Fries / BP 10142 / 67404 Illkirch CEDEX / France Tél +33 (0)3 88 65 32 00 / Fax +33 (0)3 88 65 32 01 / directeur.igbmc@igbmc.fr