The Team
  • Researchers

    Julien VERMOT

  • Post-Doctoral Fellowships

    Francesco BOSELLI

    Pedro CAMPINHO

    Emilie HECKEL

    Emily STEED

  • Phd Students

    Rita FERREIRA

    Caroline RAMSPACHER

  • Engineers & Technicians

    Nathalie FAGGIANELLI

    Stéphane ROTH

Development and stem cells

Mechano-genetic interplays and embryonic morphogenesis

During embryonic development, cells act as force sensors and can actively trigger physical changes in order to maintain the harmonious body-plan patterning and growth. Defects in these processes can cause catastrophic developmental abnormalities, in particular in the cardiovascular system where blood flow is generating shear forces essential for cardiogenesis. Our goal is to understand the dynamics and the roles of biological flow during the development of the zebrafish. We use live imaging techniques, cell biology and genetic analysis to characterize the physical stimuli and the molecular mechanisms that specify cell responses to flow forces during embryogenesis. In particular, we are interested in understanding the relationship between blood flow and tissue organization during cardiovascular development. We also investigate how cells alter and maintain their physical environment during morphogenesis. To address this question, we study the activity of beating cilia during embryogenesis using novel imaging techniques to visualize and analyze cilia mediated flow. Our work will permit to better understand the origins of congenital diseases such as cardiomyopathies, valvulopathies and ciliopathies as well as abnormal conditions like atherosclerosis and tumor spreading.

Imprimer Envoyer

Université de Strasbourg
INSERM
CNRS

IGBMC - CNRS UMR 7104 - Inserm U 964
1 rue Laurent Fries / BP 10142 / 67404 Illkirch CEDEX / France Tél +33 (0)3 88 65 32 00 / Fax +33 (0)3 88 65 32 01 / directeur.igbmc@igbmc.fr