Mechano-genetic interplays and embryonic morphogenesis
During embryonic development, cells act as force sensors and can actively trigger physical changes in order to maintain the harmonious body-plan patterning and growth. Defects in these processes can cause catastrophic developmental abnormalities, in particular in the cardiovascular system where blood flow is generating shear forces essential for cardiogenesis. Our goal is to understand the dynamics and the roles of biological flow during the development of the zebrafish. We use live imaging techniques, cell biology and genetic analysis to characterize the physical stimuli and the molecular mechanisms that specify cell responses to flow forces during embryogenesis. In particular, we are interested in understanding the relationship between blood flow and tissue organization during cardiovascular development. We also investigate how cells alter and maintain their physical environment during morphogenesis. To address this question, we study the activity of beating cilia during embryogenesis using novel imaging techniques to visualize and analyze cilia mediated flow. Our work will permit to better understand the origins of congenital diseases such as cardiomyopathies, valvulopathies and ciliopathies as well as abnormal conditions like atherosclerosis and tumor spreading.
High speed imaging of the zebrafish beating heart with the gata1::dsred transgenic line. Recording speed: 120 frames/second.
Movie by Emily Steed, IGBMC.
- Cellular mechanisms controlling valve development in response to blood flow
- Mechanotransduction in the cardiovascular system
- Models of cardiomyopathies suitable for drug screening
- Blood flow and vascular development
- Cilia mediated flow and left-right patterning
- Jonathan Freund, University of Illinois, Urbana, USA.
- Michael Liebling, UCSB, USA.
- Willy Supatto, LOB, Ecole Polytechnique, Palaiseau, France.
- Dimitris Beis, Academy of Athens, Greece.
- Andrej Vilfan, J. Stefan Institute, Ljubljana, Slovenia.
- Rita Ferreira - Thesis Prize - Société des Amis des Universités de l'Académie de Strasbourg - 2018
- Julien VERMOT - ERC Consolidator Grant - European Research Council (ERC) - 2015
- Julien VERMOT - Prix fondation Université de Strasbourg - Cercle Gutenberg - Fondation Université de Strasbourg - 2015
- Julien VERMOT - EMBO Young Investigator Programme award - European Molecular Biology Organisation - 2013
- Jacky GOETZ - Young researcher prize 2012 - Société de Biologie Cellulaire de France (SBCF) - 2013
- Julien VERMOT - Career Development Award - Human Frontier Science Program (HFSP) - 2010
- Julien VERMOT - ATIP - AVENIR starting grant - Inserm / CNRS - 2009
- Nov. 20, 2018 - The asymmetrical orientation of the lashes in the right-left organizer of the zebra fish
- Sept. 25, 2018 - A new method for observing the formation of tissues with complex geometries
- Nov. 28, 2017 - A new step in the understanding of heart valve training
- June 14, 2017 - Differentiating left from right in embryos: physics and biology approaches team-up to address mechanism of symmetry breaking in zebrafish
- May 25, 2016 - The formation of heart valves finally determined
- April 25, 2016 - IGBMC Researchers once again distinguished by the European Research Council
- June 5, 2015 - High resolution in vivo images of Zebrafish to understand proteinopathies
- Feb. 20, 2014 - Cilia: they bend but do not break
- Nov. 6, 2013 - Julien Vermot, laureate of the EMBO YIP Award 2013
- Feb. 15, 2011 - Cilia, engines of biomineralization
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J Cell Sci July 30, 2019 ; 132:jcs213496 .
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