IGBMC : Institut de la Génétique et de la Biologie Moléculaire et Cellulaire

• Chercheurs

  Didier DEVYS

  Laszlo TORA

  Stéphane VINCENT

• Post-Doctorants

  Sascha CONIC

  Farrah EL SAAFIN

• Doctorants

  Véronique FISCHER

  Vincent HISLER

  Pooja MUKHERJEE

  Kenny SCHUMACHER

  Fang WANG

  Changwei YU

• Ingénieurs & Techniciens

  Elisabeth SCHEER

  Matthieu STIERLE

• Collaborateur Occasionnel

  Gizem CALISKAN

Biologie du développement et cellules souches

Modifications de la chromatine et régulation de la transcription des gènes lors de la différentiation cellulaire

Publications

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• [Role of chromatin alterations in neurodegeneration induced by polyglutamine-expanded ataxin-7.]

  Helmlinger D., Tora L., Devys D.

  Med Sci (Paris) Aug-Sep 2006;22:700-702.

• The transcriptional histone acetyltransferase cofactor TRRAP associates with the MRN repair complex and plays a role in DNA double-strand break repair

  Robert F., Hardy S., Nagy Z., Baldeyron C., Murr R., Dery U., Masson J.Y., Papadopoulo D., Herceg Z., Tora L.

  Mol Cell Biol Jan 2006;26:402-12.

• An hGCN5/TRRAP histone acetyltransferase complex co-activates BRCA1 transactivation function through histone modification

  Oishi H., Kitagawa H., Wada O., Takezawa S., Tora L., Kouzu-Fujita M., Takada I., Yano T., Yanagisawa J., Kato S.

  J Biol Chem 6 janvier 2006;281:20-6.

• Transcriptional alterations and chromatin remodeling in polyglutamine diseases

  Helmlinger D., Tora L., Devys D.

  Trends Genet Oct 2006;22:562-70.

• Two isoforms of Drosophila TRF2 are involved in embryonic development, premeiotic chromatin condensation, and proper differentiation of germ cells of both sexes

  Kopytova D.V., Krasnov A.N., Kopantceva M.R., Nabirochkina E.N., Nikolenko J.V., Maksimenko O., Kurshakova M.M., Lebedeva L.A., Yerokhin M.M., Simonova O.B., Korochkin L.I., Tora L., Georgiev P.G., Georgieva S.G.

  Mol Cell Biol Oct 2006;26:7492-505.

• The proteasome restricts permissive transcription at tissue-specific gene loci in embryonic stem cells

  Szutorisz H., Georgiou A., Tora L., Dillon N.

  Cell 29 décembre 2006;127:1375-88.

• Both normal and polyglutamine-expanded ataxin-7 are components TFTC-type GCN4 histone acetyltransferase-containing complexes

  Helmlinger D., Hardy S., Eberlin A., Devys D., Toras L.

  Biochem. Soc. Symp. 2006;73:155-63.

• Formation of an active tissue-specific chromatin domain initiated by epigenetic marking at the embryonic stem cell stage

  Szutorisz H., Canzonetta C., Georgiou A., Chow C.M., Tora L., Dillon N.

  Mol Cell Biol Mar 2005;25:1804-20.