IGBMC : Institut de la Génétique et de la Biologie Moléculaire et Cellulaire

• Chercheurs

  Adèle DE ARCANGELIS

  Gérard GRADWOHL

  Valérie SCHREIBER

• Post-Doctorants

  Sabitri GHIMIRE

  Constance VAGNE

• Doctorants

  Florence BLOT

  Julia GRANS

  Sara JIMENEZ CORREA

• Ingénieurs & Techniciens

  Céline LAPP

  Aline MEUNIER

• Collaborateur Occasionnel

  Maroua BEN RHOUMA

Biologie du développement et cellules souches

Différenciation et physiopathologie des cellules endocrines pancréatiques et intestinales

Publications

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• Adult duct-lining cells can reprogram into beta-like cells able to counter repeated cycles of toxin-induced diabetes.

  Al-Hasani K, Pfeifer A, Courtney M, Ben-Othman N, Gjernes E, Vieira A, Druelle N, Avolio F, Ravassard P, Leuckx G, Lacas-Gervais S, Ambrosetti D, Benizri E, Hecksher-Sorensen J, Gounon P, Ferrer J, Gradwohl G, Heimberg H, Mansouri A, Collombat P.

  Dev Cell 15 juillet 2013;26:86-100.

• The transcriptional co-repressor Grg3/Tle3 promotes pancreatic endocrine progenitor delamination and -cell differentiation.

  Metzger DE, Gasperowicz M, Otto F, Cross JC, Gradwohl G, Zaret KS.

  Development Apr 2012;139:1447-56.

• The homeodomain-containing transcription factors Arx and Pax4 control enteroendocrine subtype specification in mice.

  Beucher A, Gjernes E, Collin C, Courtney M, Meunier A, Collombat P, Gradwohl G.

  PLoS One 2012;7:e36449.

• Competence of failed endocrine progenitors to give rise to acinar but not ductal cells is restricted to early pancreas development

  Beucher A., Martin M., Spenle C., Poulet M., Collin C., Gradwohl G.

  Developmental biology 15 janvier 2012;361:277-85.

• Pancreatic islet and progenitor cell surface markers with cell sorting potential.

  Hald J, Galbo T, Rescan C, Radzikowski L, Sprinkel AE, Heimberg H, Ahnfelt-Rønne J, Jensen J, Scharfmann R, Gradwohl G, Kaestner KH, Stoeckert C Jr, Jensen JN, Madsen OD.

  Diabetologia Jan 2012;55:154-65.

• Differential requirements for neurogenin 3 in the development of POMC and NPY neurons in the hypothalamus

  Pelling M., Anthwal N., McNay D., Gradwohl G., Leiter A.B., Guillemot F., Ang S.L.

  Dev Biol 15 janvier 2011;349:406-16.

• Enteroendocrine cells and lipid absorption

  Mellitzer G., Gradwohl G.

  Curr Opin Lipidol Jun 2011;22:171-5.

• Distinct ATOH1 and Neurog3 requirements define tuft cells as a new secretory cell type in the intestinal epithelium

  Gerbe F., van Es J.H., Makrini L., Brulin B., Mellitzer G., Robine S., Romagnolo B., Shroyer N.F., Bourgaux J.F., Pignodel C., Clevers H., Jay P.

  J Cell Biol 7 mars 2011;192:767-80.