IGBMC : Institut de la Génétique et de la Biologie Moléculaire et Cellulaire

• Researchers

  Susan CHAN

  Céline CHARVET

  Beate HEIZMANN

  Philippe KASTNER

  Peggy KIRSTETTER

• PhD Students

  Chiara BERNARDI

  Giovanni COVA

  Marie-Céline DEAU

  Guillaume MOREL

  Célestine SIMAND

• Engineers & Technicians

  Patricia MARCHAL

Functional genomics and cancer

Hematopoiesis and leukemogenesis in the mouse

Publications

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• Large deletions of the 5' region of IKZF1 lead to haploinsufficiency in B-cell precursor acute lymphoblastic leukaemia.

  Morel G(1)(2)(3)(4)(5), Deau MC(1)(2)(3)(4), Simand C(1)(2)(3)(4)(5), Caye-Eude A(6)(7), Arfeuille C(6)(7), Ittel A(8), Miguet L(8)(9)(10), Mauvieux L(8)(9)(10), Herbrecht R(5)(9)(10), Paillard C(10)(11)(12), Strullu M(7)(13), Cave H(6)(7), Chan S(1)(2)(3)(4), Kastner P(1)(2)(3)(4)(10), Heizmann B(1)(2)(3)(4).

  Br J Haematol May 30, 2019.

• CBP and P300 regulate distinct gene networks required for human primary myoblast differentiation and muscle integrity.

  Fauquier L(1), Azzag K(1)(2), Parra MAM(3), Quillien A(1), Boulet M(1)(4), Diouf S(1)(4), Carnac G(5), Waltzer L(1)(4), Gronemeyer H(3), Vandel L(6)(7).

  Sci Rep Aug. 22, 2018;8:12629.

• Ikaros cooperates with Notch activation and antagonizes TGFbeta signaling to promote pDC development.

  Mastio J(1), Simand C(1), Cova G(1), Kastner P(1)(2), Chan S(1), Kirstetter P(1).

  PLoS Genet July 12, 2018;14:e1007485.

• Severe combined immunodeficiency in stimulator of interferon genes (STING) V154M/wild-type mice.

  Bouis D(1), Kirstetter P(2), Arbogast F(3), Lamon D(1), Delgado V(1), Jung S(4), Ebel C(2), Jacobs H(5), Knapp AM(6), Jeremiah N(7), Belot A(8), Martin T(9), Crow YJ(10), Andre-Schmutz I(11), Korganow AS(9), Rieux-Laucat F(12), Soulas-Sprauel P(13).

  J Allergy Clin Immunol Feb 2018;143:712-725.

• Requirement of GSK-3 for PUMA induction upon loss of pro-survival PI3K signaling.

  Schubert F(1)(2)(3), Rapp J(1)(3), Brauns-Schubert P(1)(2)(3)(4), Schlicher L(1)(2)(3)(4), Stock K(1)(3), Wissler M(1), Wei M(1), Charvet C(5), Borner C(1)(2)(4), Maurer U(6)(7)(8).

  Cell Death Dis April 23, 2018;9:470.

• Treatment of MCPT8DTR mice with high- or low-dose diphtheria toxin leads to differential depletion of basophils and granulocyte-macrophage progenitors.

  El Hachem C(1), Hener P(1), Kirstetter P(1), Li J(1), Chan S(1), Li M(1).

  Eur J Immunol May 2018;48:861-873.

• The Ikaros family in lymphocyte development.

  Heizmann B(1), Kastner P(2), Chan S(3).

  Curr Opin Immunol Apr 2018;51:14-23.

• Therapeutical modulation of plasmacytoid dendritic cells in experimental arthritis.

  Nehmar R(1)(2), Alsaleh G(1)(2), Voisin B(3), Flacher V(3), Mariotte A(1)(2), Saferding V(4), Puchner A(4), Niederreiter B(4), Vandamme T(5), Schabbauer G(6), Kastner P(7), Chan S(7), Kirstetter P(7), Holcmann M(8), Mueller C(3), Sibilia J(1)(2), Bahram S(1)(2), Bluml S(4), Georgel P(1)(2).

  Arthritis Rheumatol Nov 2017;69:2124-2135.