Large deletions of the 5' region of IKZF1 lead to haploinsufficiency in B-cell precursor acute lymphoblastic leukaemia.
Morel G(1)(2)(3)(4)(5), Deau MC(1)(2)(3)(4), Simand C(1)(2)(3)(4)(5), Caye-Eude A(6)(7), Arfeuille C(6)(7), Ittel A(8), Miguet L(8)(9)(10), Mauvieux L(8)(9)(10), Herbrecht R(5)(9)(10), Paillard C(10)(11)(12), Strullu M(7)(13), Cave H(6)(7), Chan S(1)(2)(3)(4), Kastner P(1)(2)(3)(4)(10), Heizmann B(1)(2)(3)(4).
Br J Haematol May 30, 2019
.
CBP and P300 regulate distinct gene networks required for human primary myoblast differentiation and muscle integrity.
Fauquier L(1), Azzag K(1)(2), Parra MAM(3), Quillien A(1), Boulet M(1)(4), Diouf S(1)(4), Carnac G(5), Waltzer L(1)(4), Gronemeyer H(3), Vandel L(6)(7).
Sci Rep Aug. 22, 2018
; 8:12629
.
Ikaros cooperates with Notch activation and antagonizes TGFbeta signaling to promote pDC development.
Mastio J(1), Simand C(1), Cova G(1), Kastner P(1)(2), Chan S(1), Kirstetter P(1).
PLoS Genet July 12, 2018
; 14:e1007485
.
Severe combined immunodeficiency in stimulator of interferon genes (STING) V154M/wild-type mice.
Bouis D(1), Kirstetter P(2), Arbogast F(3), Lamon D(1), Delgado V(1), Jung S(4), Ebel C(2), Jacobs H(5), Knapp AM(6), Jeremiah N(7), Belot A(8), Martin T(9), Crow YJ(10), Andre-Schmutz I(11), Korganow AS(9), Rieux-Laucat F(12), Soulas-Sprauel P(13).
J Allergy Clin Immunol Feb 2018
; 143:712-725
.
Requirement of GSK-3 for PUMA induction upon loss of pro-survival PI3K signaling.
Schubert F(1)(2)(3), Rapp J(1)(3), Brauns-Schubert P(1)(2)(3)(4), Schlicher L(1)(2)(3)(4), Stock K(1)(3), Wissler M(1), Wei M(1), Charvet C(5), Borner C(1)(2)(4), Maurer U(6)(7)(8).
Cell Death Dis April 23, 2018
; 9:470
.
Treatment of MCPT8DTR mice with high- or low-dose diphtheria toxin leads to differential depletion of basophils and granulocyte-macrophage progenitors.
El Hachem C(1), Hener P(1), Kirstetter P(1), Li J(1), Chan S(1), Li M(1).
Eur J Immunol May 2018
; 48:861-873
.
The Ikaros family in lymphocyte development.
Heizmann B(1), Kastner P(2), Chan S(3).
Curr Opin Immunol Apr 2018
; 51:14-23
.
Therapeutical modulation of plasmacytoid dendritic cells in experimental arthritis.
Nehmar R(1)(2), Alsaleh G(1)(2), Voisin B(3), Flacher V(3), Mariotte A(1)(2), Saferding V(4), Puchner A(4), Niederreiter B(4), Vandamme T(5), Schabbauer G(6), Kastner P(7), Chan S(7), Kirstetter P(7), Holcmann M(8), Mueller C(3), Sibilia J(1)(2), Bahram S(1)(2), Bluml S(4), Georgel P(1)(2).
Arthritis Rheumatol Nov 2017
; 69:2124-2135
.
Helios expression coordinates the development of a subset of striatopallidal medium spiny neurons.
Martin-Ibanez R(1)(2)(3)(4)(5), Pardo M(1)(2)(3)(4), Giralt A(3)(4)(6), Miguez A(1)(2)(3)(4), Guardia I(1)(2)(3)(4), Marion-Poll L(7), Herranz C(1)(2)(3)(4)(5), Esgleas M(1)(3)(4), Garcia-Diaz Barriga G(2)(3)(4)(6), Edel MJ(8)(9)(10), Vicario-Abejon C(4)(11), Alberch J(2)(3)(4), Girault JA(7), Chan S(1)(2), Kastner P(12)(13), Canals JM(14)(2)(3)(4)(5).
Development April 15, 2017
; 144:1566-1577
.
Comments on: fold change rank ordering statistics: a new method for detecting differentially expressed genes.
Dembele D(1,)(2), Kastner P(3,)(4).
BMC Bioinformatics Nov. 15, 2016
; 17:462
.
Ikaros Inhibits Group 3 Innate Lymphoid Cell Development and Function by Suppressing the Aryl Hydrocarbon Receptor Pathway.
Li S(1), Heller JJ(2), Bostick JW(3), Lee A(2), Schjerven H(4), Kastner P(5), Chan S(5), Chen ZE(6), Zhou L(7).
Immunity July 19, 2016
; 45:185-97
.
Sumoylation Inhibits the Growth Suppressive Properties of Ikaros.
Apostolov A(1), Litim-Mecheri I(1), Oravecz A(1), Goepp M(1), Kirstetter P(1), Marchal P(1), Ittel A(2,)(3), Mauvieux L(2,)(3), Chan S(1), Kastner P(1,)(4).
PLoS One June 17, 2016
; 11:e0157767
.
Ikaros Is a Negative Regulator of B1 Cell Development and Function.
Macias-Garcia A(1), Heizmann B(2), Sellars M(1), Marchal P(1), Dali H(3), Pasquali JL(4), Muller S(5), Kastner P(6), Chan S(7).
J Biol Chem April 22, 2016
; 291:9073-86
.
Ikaros limits follicular B cell activation by regulating B cell receptor signaling pathways.
Heizmann B(1), Sellars M(2), Macias-Garcia A(3), Chan S(4), Kastner P(5).
Biochem Biophys Res Commun Feb. 12, 2016
; 470:714-20
.
Stable inhibitory activity of regulatory T cells requires the transcription factor Helios.
Kim HJ(1), Barnitz RA(2), Kreslavsky T(1), Brown FD(3), Moffett H(4), Lemieux ME(5), Kaygusuz Y(4), Meissner T(1), Holderried TA(1), Chan S(6), Kastner P(6), Haining WN(7), Cantor H(8).
Science Oct. 16, 2015
; 350:334-9
.
Ikaros mediates gene silencing in T cells through Polycomb repressive complex 2.
Oravecz A(1), Apostolov A(1), Polak K(1), Jost B(2), Le Gras S(2), Chan S(1), Kastner P(1,)(3).
Nat Commun Nov. 9, 2015
; 6:8823
.
A survey of conservation of sea spider and Drosophila Hox protein activities.
Saadaoui M(1), Litim-Mecheri I(2), Macchi M(3), Graba Y(3), Maurel-Zaffran C(3).
Mech Dev Nov 2015
; 138:73-86
.
IKZF1 deletion is an independent prognostic marker in childhood B-cell precursor acute lymphoblastic leukemia, and distinguishes patients benefiting from pulses during maintenance therapy: results of the EORTC Children's Leukemia Group study 58951.
Clappier E(1,)(2), Grardel N(3), Bakkus M(4), Rapion J(5), De Moerloose B(6), Kastner P(7), Caye A(1,)(2), Vivent J(1,)(2), Costa V(8), Ferster A(9), Lutz P(10), Mazingue F(11), Millot F(12), Plantaz D(13), Plat G(14), Plouvier E(15), Poirée M(16), Sirvent N(17), Uyttebroeck A(18), Yakouben K(19), Girard S(20), Dastugue N(21), Suciu S(5), Benoit Y(6), Bertrand Y(22), Cavé H(1,)(2); European Organisation for Research and Treatment of Cancer, Children's Leukemia Group (EORTC-CLG).
Leukemia Nov 2015
; 29:2154-61
.
The tumor suppressor Ikaros shapes the repertoire of notch target genes in T cells.
Geimer Le Lay AS(1), Oravecz A, Mastio J, Jung C, Marchal P, Ebel C, Dembélé D, Jost B, Le Gras S, Thibault C, Borggrefe T, Kastner P, Chan S.
Sci Signal March 18, 2014
; 7:ra28
.
Fold change rank ordering statistics: a new method for detecting differentially expressed genes.
Dembélé D(1), Kastner P.
BMC Bioinformatics Jan. 15, 2014
; 15:14
.
Ikaros is absolutely required for pre-B cell differentiation by attenuating IL-7 signals.
Heizmann B, Kastner P, Chan S.
J Exp Med Dec. 16, 2013
; 210:2823-32
.
beta-Catenin activation synergizes with Pten loss and Myc overexpression in Notch-independent T-ALL.
Kaveri D, Kastner P, Dembélé D, Nerlov C, Chan S, Kirstetter P.
Blood Aug. 1, 2013
; 122:694-704
.
Function of Ikaros as a tumor suppressor in B cell acute lymphoblastic leukemia.
Kastner P, Dupuis A, Gaub MP, Herbrecht R, Lutz P, Chan S.
Am J Blood Res 2013
; 3:1-13
.
Biclonal and biallelic deletions occur in 20% of B-ALL cases with IKZF1 mutations.
Dupuis A, Gaub MP, Legrain M, Drenou B, Mauvieux L, Lutz P, Herbrecht R, Chan S, Kastner P.
Leukemia Feb 2013 2013
; 27:503-7
.
Helios transcription factor expression depends on Gsx2 and Dlx1&2 function in developing striatal matrix neurons.
Martín-Ibáñez R(1), Crespo E, Esgleas M, Urban N, Wang B, Waclaw R, Georgopoulos K, Martínez S, Campbell K, Vicario-Abejón C, Alberch J, Chan S, Kastner P, Rubenstein JL, Canals JM.
Stem Cells Dev Aug. 10, 2012
; 21:2239-51
.
Pivotal role of plasmacytoid dendritic cells in inflammation and NK-cell responses after TLR9 triggering in mice.
Guillerey C(1), Mouriès J, Polo G, Doyen N, Law HK, Chan S, Kastner P, Leclerc C, Dadaglio G.
Blood July 5, 2012
; 120:90-9
.
A multiply redundant genetic switch 'locks in' the transcriptional signature of regulatory T cells.
Fu W, Ergun A, Lu T, Hill JA, Haxhinasto S, Fassett MS, Gazit R, Adoro S, Glimcher L, Chan S, Kastner P, Rossi D, Collins JJ, Mathis D, Benoist C.
Nat Immunol Oct 2013 2012
; 13:972-80
.
Role of Ikaros in T-cell acute lymphoblastic leukemia
Kastner P., Chan S.
World J Biol Chem June 26, 2011
; 2:108-14
.
Ikaros in B cell development and function
Sellars M., Kastner P., Chan S.
World J Biol Chem June 26, 2011
; 2:132-9
.
Helios is associated with CD4 T cells differentiating to T helper 2 and follicular helper T cells in vivo independently of foxp3 expression
Serre K., Benezech C., Desanti G., Bobat S., Toellner K.M., Bird R., Chan S., Kastner P., Cunningham A.F., Maclennan I.C., Mohr E.
PLoS ONE 2011
; 6:e20731
.
Deletion-based mechanisms of Notch1 activation in T-ALL: key roles for RAG recombinase and a conserved internal translational start site in Notch1
Ashworth T.D., Pear W.S., Chiang M.Y., Blacklow S.C., Mastio J., Xu L., Kelliher M., Kastner P., Chan S., Aster J.C.
Blood Dec. 16, 2010
; 116:5455-64
.
Oncogenic activation of the Notch1 gene by deletion of its promoter in Ikaros-deficient T-ALL
Jeannet R., Mastio J., Macias-Garcia A., Oravecz A., Ashworth T., Geimer Le Lay A.S., Jost B., Le Gras S., Ghysdael J., Gridley T., Honjo T., Radtke F., Aster J.C., Chan S., Kastner P.
Blood Dec. 16, 2010
; 116:5443-54
.
Bcl11b represses a mature T-cell gene expression program in immature CD4(+)CD8(+) thymocytes
Kastner P., Chan S., Vogel W.K., Zhang L.J., Topark-Ngarm A., Golonzhka O., Jost B., Le Gras S., Gross M.K., Leid M.
Eur J Immunol Aug 2010
; 40:2143-54
.
Genetic inactivation of Ikaros is a rare event in human T-ALL
Marcais A., Jeannet R., Hernandez L., Soulier J., Sigaux F., Chan S., Kastner P.
Leuk Res Apr 2010
; 34:426-429
.
Haploinsufficiency of the IKZF1 (IKAROS) tumor suppressor gene cooperates with BCR-ABL in a transgenic model of acute lymphoblastic leukemia
Virely C., Moulin S., Cobaleda C., Lasgi C., Alberdi A., Soulier J., Sigaux F., Chan S., Kastner P., Ghysdael J.
Leukemia Jun 2010
; 24:1200-4
.
Helios deficiency has minimal impact on T cell development and function
Cai Q., Dierich A., Oulad-Abdelghani M., Chan S., Kastner P.
J Immunol Aug. 15, 2009
; 183:2303-11
.
MafB restricts M-CSF-dependent myeloid commitment divisions of hematopoietic stem cells
Sarrazin S., Mossadegh-Keller N., Fukao T., Aziz A., Mourcin F., Vanhille L., Kelly Modis L., Kastner P., Chan S., Duprez E., Otto C., Sieweke M.H.
Cell July 23, 2009
; 138:300-13
.
Ikaros controls isotype selection during immunoglobulin class switch recombination
Sellars M., Reina-San-Martin B., Kastner P., Chan S.
J Exp Med May 11, 2009
; 206:1073-87
.
Plasmacytoid dendritic cells are dispensable during primary influenza virus infection
Wolf A.I., Buehler D., Hensley S.E., Cavanagh L.L., Wherry E.J., Kastner P., Chan S., Weninger W.
J Immunol Jan. 15, 2009
; 182:871-9
.
PU.1: A crucial and versatile player in hematopoiesis and leukemia
Kastner P., Chan S.
Int J Biochem Cell Biol 2008
; 40:22-7
.
Ikaros represses the transcriptional response to notch signaling in T-cell development
Kleinmann E., Geimer Le Lay A.S., Sellars M., Kastner P., Chan S.
Mol Cell Biol Dec 2008
; 28:7465-75
.
Novel insights into the relationships between dendritic cell subsets in human and mouse revealed by genome-wide expression profiling
Robbins S.H., Walzer T., Dembele D., Thibault C., Defays A., Bessou G., Xu H., Vivier E., Sellars M., Pierre P., Sharp F.R., Chan S., Kastner P., Dalod M.
Genome Biol Jan. 24, 2008
; 9:R17
.
Reciprocal activation of GATA-1 and PU.1 marks initial specification of hematopoietic stem cells into myeloerythroid and myelolymphoid lineages
Arinobu Y., Mizuno S.I., Chong Y., Shigematsu H., Lino T., Iwasaki H., Graf T., Mayfield R., Chan S., Kastner P., Akashi K.
CELL STEM CELL Oct. 2007 2007
; 1:416-27
.
PU.1 (Sfpi1), a pleiotropic regulator expressed from the first embryonic stages with a crucial function in germinal progenitors
Olive V., Wagner N., Chan S., Kastner P., Vannetti C., Cuzin F., Rassoulzadegan M.
Development Nov 2007
; 134:3815-25
.
Ikaros is required for plasmacytoid dendritic cell differentiation
Allman D., Dalod M., Asselin-Paturel C., Delale T., Robbins S.H., Trinchieri G., Biron C.A., Kastner P., Chan S.
Blood Dec. 15, 2006
; 108:4025-34
.
Absence of the steroid receptor coactivator-3 induces B-cell lymphoma
Coste A., Antal M.C., Chan S., Kastner P., Mark M., O'Malley B.W., Auwerx J.
Embo J June 7, 2006
; 25:2453-64
.
Notch Activation Is an Early and Critical Event during T-Cell Leukemogenesis in Ikaros-Deficient Mice
Dumortier A., Jeannet R., Kirstetter P., Kleinmann E., Sellars M., Dos Santos N.R., Thibault C., Barths J., Ghysdael J., Punt J.A., Kastner P., Chan S.
Mol Cell Biol Jan 2006
; 26:209-20
.
[Notch activation during T-cell leukemogenesis in Ikaros-deficient mice.]
Kastner P., Chan S.
Med Sci (Paris) Aug-Sep 2006
; 22:708-10
.
An open-access long oligonucleotide microarray resource for analysis of the human and mouse transcriptomes
Le Brigand K., Russell R., Moreilhon C., Rouillard J.M., Jost B., Amiot F., Magnone V., Bole-Feysot C., Rostagno P., Virolle V., Defamie V., Dessen P., Williams G., Lyons P., Rios G., Mari B., Gulari E., Kastner P., Gidrol X., Freeman T.C., Barbry P.
Nucleic Acids Res 2006
; 34:e87
.
Visualizing PU.1 activity during hematopoiesis
Back J., Allman D., Chan S., Kastner P.
Exp Hematol Apr 2005
; 33:395-402
.
MyD88-dependent and -independent murine cytomegalovirus sensing for IFN-alpha release and initiation of immune responses in vivo
Delale T., Paquin A., Asselin-Paturel C., Dalod M., Brizard G., Bates E.E., Kastner P., Chan S., Akira S., Vicari A., Biron C.A., Trinchieri G., Briere F.
J Immunol Nov. 15, 2005
; 175:6723-32
.
Distinctive and indispensable roles of PU.1 in maintenance of hematopoietic stem cells and their differentiation
Iwasaki H., Somoza C., Shigematsu H., Duprez E.A., Iwasaki-Arai J., Mizuno S., Arinobu Y., Geary K., Zhang P., Dayaram T., Fenyus M.L., Elf S., Chan S., Kastner P., Huettner C.S., Murray R., Tenen D.G., Akashi K.
Blood Sept. 1, 2005
; 106:1590-600
.
PU.1 determines the self-renewal capacity of erythroid progenitor cells
Back J., Dierich A., Bronn C., Kastner P., Chan S.
Blood May 15, 2004
; 103:3615-23
.
Enhanced bone formation in lipodystrophic PPARgamma(hyp/hyp) mice relocates haematopoiesis to the spleen
Cock T.A., Back J., Elefteriou F., Karsenty G., Kastner P., Chan S., Auwerx J.
EMBO Rep Oct 2004
; 5:1007-12
.
Fuzzy C-means method for clustering microarray data
Dembele D., Kastner P.
Bioinformatics May 22, 2003
; 19:973-80
.
Ikaros regulates neutrophil differentiation
Dumortier A., Kirstetter P., Kastner P., Chan S.
Blood March 15, 2003
; 101:2219-26
.
Ikaros is critical for B cell differentiation and function
Kirstetter P., Thomas M., Dierich A., Kastner P., Chan S.
Eur J Immunol 2002
; 32:720-30.
.
Selective ablation of retinoid X receptor alpha in hepatocytes impairs their lifespan and regenerative capacity
Imai T., Jiang M., Kastner P., Chambon P., Metzger D.
Proc Natl Acad Sci U S A 2001
; 98:4581-4586.
.
Function of RARalpha during the maturation of neutrophils
Kastner P., Chan S.
Oncogene 2001
; 20:7178-85.
.
Positive and negative regulation of granulopoiesis by endogenous RARalpha
Kastner P., Lawrence H.J., Waltzinger C., Ghyselinck N.B., Chambon P., Chan S.
Blood 2001
; 97:1314-1320.
.
RXRalpha overexpression in cardiomyocytes causes dilated cardiomyopathy but fails to rescue myocardial hypoplasia in RXRalpha-null fetuses
Subbarayan V., Mark M., Messadeq N., Rustin P., Chambon P., Kastner P.
J Clin Invest 2000
; 105:387-94
.
An influence of CD5 on the selection of CD4-lineage T cells
Chan S., Waltzinger C., Tarakhovsky A., Benoist C., Mathis D.
Eur J Immunol 1999
; 29:2916-2922
.
Differential expression of retinoid receptors in the adult mouse central nervous system
Krezel W., Kastner P., Chambon P.
Neuroscience 1999
; Vol 89, Iss 4:1291-1300
.
A genetic dissection of the retinoid signalling pathway in the mouse
Mark M., Ghyselinck N.B., Wendling O., Dupe V., Mascrez B., Kastner P., Chambon P.
Proc Nutr Soc 1999
; 58:609-13
.
Negative regulation of CD4 lineage development and responses by CD5
Pena-Rossi C., Zuckerman L.A., Strong J., Kwan J., Ferris W., Chan S., Tarakhovsky A., Beyers A.D., Killeen N.
J Immunol 1999
; 163:6494-501
.
Absence of thyroid hormone receptor beta-retinoid X receptor interactions in auditory function and in the pituitary-thyroid axis
Barros A.C., Erway L.C., Krezel W., Curran T., Kastner P., Chambon P., Forrest D.
Neuroreport 1998
; Vol 9, Iss 13:2933-2937
.
Both retinoic acid receptors alpha (RAR alpha) and gamma(RAR gamma) are able to initiate mouse upper-lip skin glandular metaplasia
Blanchet S., Favier B., Chevalier G., Kastner P., Michaille J.J., Chambon P., Dhouailly D.
J.Invest.Dermatol. 1998
; Vol 111, Iss 2:206-212
.
CD4/CD8 lineage commitment: matching fate with competence
Chan S., Correia-Neves M., Benoist C., Mathis D.
Immunol.Rev. 1998
; Vol 165:195-207
.
Visualization of CD4/CD8 T cell commitment
Chan S., Correia-Neves M., Dierich A., Benoist C., Mathis D.
J.Exp.Med. 1998
; Vol 188, Iss 12:2321-2333
.
Impaired locomotion and dopamine signaling in retinoid receptor mutant mice
Krezel W., Ghyselinck N., Samad T.A., Dupe V., Kastner P., Borrelli E., Chambon P.
Science 1998
; Vol 279, Iss 5352:863-867
.
Mesectoderm is a major target of retinoic acid action
Mark M., Ghyselinck N.B., Kastner P., Dupe V., Wendling O., Krezel W., Mascrez B., Chambon P.
Eur.J.Oral.Sci. 1998
; Vol 106:24-31
.
The RXR alpha ligand-dependent activation function 2 (AF-2) is important for mouse development
Mascrez B., Mark M., Dierich A., Ghyselinck N.B., Kastner P., Chambon P.
Development 1998
; Vol 125, Iss 23:4691-4707
.
Genetic evidence that the retinoid signal is transduced by heterodimeric RXR/RAR functional units during mouse development
Kastner P., Mark M., Ghyselinck N., Krezel W., Dupe V., Grondona J.M., Chambon P.
Development 1997
; Vol 124, Iss 2:313-326
.
Vitamin a deficiency and mutations of RXR alpha, RXR beta and RAR alpha lead to early differentiation of embryonic ventricular cardiomyocytes
Kastner P., Messaddeq N., Mark M., Wendling O., Grondona J.M., Ward S., Ghyselinck N., Chambon P.
Development 1997
; Vol 124, Iss 23:4749-4758
.
[Genetic control of the development by retinoic acid]
Mark M., Kastner P., Ghyselinck N.B., Krezel W., Dupe V., Chambon P.
C.R.Seances.Soc.Biol.Fil. 1997
; 191:77-90
.
Defects of the chorioallantoic placenta RXR alpha null fetuses
Sapin V., Dolle P., Hindelang C., Kastner P., Chambon P.
Dev.Biol. 1997
; Vol 191, Iss 1:29-41
.
Limited specificity and large overlap of the functions of the mouse RAR gamma 1 and RAR gamma 2 isoforms
Subbarayan V., Kastner P., Mark M., Dierich A., Gorry P., Chambon P.
Mech.Develop. 1997
; Vol 66, Iss 1-2:131-142
.
Two novel RXR alpha isoforms from mouse testis
Brocard J., Kastner P., Chambon P.
Biochem.Biophys.Res.Commun. 1996
; Vol 229, Iss 1:211-218
.
Retinal dysplasia and degeneration in RARbeta2/RARgamma2 compound mutant mice
Grondona J.M., Kastner P., Gansmuller A., Decimo D., Chambon P., Mark M.
Development 1996
; 122:2173-2188
.
Abnormal spermatogenesis in RXR beta mutant mice
Kastner P., Mark M., Leid M., Gansmuller A., Chin W., Grondona J.M., Decimo D., Krezel W., Dierich A., Chambon P.
Genes.Dev. 1996
; 10:80-92
.
RXR gamma null mice are apparently normal and compound RXR alpha +/-/RXR beta -/-/RXR gamma -/- mutant mice are viable
Krezel W., Dupe V., Mark M., Dierich A., Kastner P., Chambon P.
Proc.Natl.Acad.Sci.U.S.A. 1996
; 93:9010-9014
.
CD1-restricted CD4+ T cells in major histocompatibility complex class II-deficient mice
Cardell S., Tangri S., Chan S., Kronenberg M., Benoist C., Mathis D.
J.Exp.Med. 1995
; 182:993-1004
.
Nonsteroid nuclear receptors: what are genetic studies telling us about their role in real life?
Kastner P., Mark M., Chambon P.
Cell 1995
; 83:859-869
.
The nuclear receptor superfamily: the second decade
Mangelsdorf D.J., Thummel C., Beato M., Herrlich P., Schutz G., Umesono K., Blumberg B., Kastner P., Mark M., Chambon P., Evans R.M.
Cell 1995
; 83:835-839
.
Roles of retinoic acid receptors and of Hox genes in the patterning of the teeth and of the jaw skeleton
Mark M., Lohnes D., Mendelsohn C., Dupe V., Vonesch J.L., Kastner P., Rijli F., Bloch-Zupan A., Chambon P.
Int.J.Dev.Biol. 1995
; 39:111-121
.
The immune system of mice lacking conventional MHC class II molecules
Cardell S., Merkenschlager M., Bodmer H., Chan S., Cosgrove D., Benoist C., Mathis D.
Adv.Immunol. 1994
; 55:423-440
.
In favor of the selective model of positive selection
Chan S.H., Benoist C., Mathis D.
Semin.Immunol. 1994
; 6:241-248
.
Role of coreceptors in positive selection and lineage commitment
Chan S.H., Waltzinger C., Baron A., Benoist C., Mathis D.
EMBO J. 1994
; 13:4482-4489
.
Developmental expression of murine retinoid X receptor (RXR) genes
Dolle P., Fraulob V., Kastner P., Chambon P.
Mech.Dev. 1994
; 45:91-104
.
Genetic analysis of RXR alpha developmental function: convergence of RXR and RAR signaling pathways in heart and eye morphogenesis
Kastner P., Grondona J.M., Mark M., Gansmuller A., Le Meur M., Decimo D., Vonesch J.L., Dolle P., Chambon P.
Cell 1994
; 78:987-1003
.
Retinoic acid receptors and retinoid X receptors: interactions with endogenous retinoic acids
Allenby G., Bocquel M.T., Saunders M., Kazmer S., Speck J., Rosenberger M., Lovey A., Kastner P., Grippo J.F., Chambon P., Levin A.A.
Proc.Natl.Acad.Sci.U.S.A. 1993
; 90:30-34
.
Environmental modulation of the autonomy of cytotoxic T lymphocytes
Bodmer H., Obert G., Chan S., Benoist C., Mathis D.
Eur.J.Immunol. 1993
; 23:1649-1654
.
A challenge to the instructive model of positive selection
Chan S.H., Benoist C., Mathis D.
Immunol.Rev. 1993
; 135:119-131
.
Another view of the selective model of thymocyte selection
Chan S.H., Cosgrove D., Waltzinger C., Benoist C., Mathis D.
Cell 1993
; 73:225-236
.
Graft rejection by T cells not restricted by conventional major histocompatibility complex molecules.
Dierich A., Chan S.H., Benoist C., Mathis D.
Eur.J.Immunol. 1993
; 23:2725-2728
.
Knock-out mice: a new tool for transplantation immunologists
Hergueux J., Bodmer H., Cardell S., Chan S.H., Cosgrove D., Benoist C., Mathis D.
Transplant.Proc. 1993
; 25:30-32
.
Function of retinoic acid receptor gamma in the mouse
Lohnes D., Kastner P., Dierich A., Mark M., Le Meur M., Chambon P.
Cell 1993
; 73:643-658
.
PMLRAR homodimers: distinct DNA binding properties and heteromeric interactions with RXR
Perez A., Kastner P., Sethi S., Lutz Y., Reibel C., Chambon P.
EMBO J. 1993
; 12:3171-3182
.
Purification, cloning, and RXR identity of the HeLa cell factor with which RAR or TR heterodimerizes to bind target sequences efficiently.
Leid M(1), Kastner P, Lyons R, Nakshatri H, Saunders M, Zacharewski T, Chen JY, Staub A, Garnier JM, Mader S, et al.
Cell Jan. 24, 1992
; 68:377-95
.
The thymic compartment responsible for positive selection of CD4+ T cells
Cosgrove D., Chan S.H., Waltzinger C., Benoist C., Mathis D.
Int.Immunol. 1992
; 4:707-710
.
Differential regulation of retinoic acid receptors and binding proteins in human skin
Elder J.T., Astrom A., Pettersson U., Tavakkol A., Griffiths C.E., Krust A., Kastner P., Chambon P., Voorhees J.J.
J.Invest.Dermatol. 1992
; 98:673-679
.
Retinoic acid receptors and binding proteins in human skin
Elder J.T., Astrom A., Pettersson U., Tavakkol A., Krust A., Kastner P., Chambon P., Voorhees J.J.
J.Invest.Dermatol. 1992
; 98:36S-41S
.
Multiplicity generates diversity in the retinoic acid signalling pathways
Leid M., Kastner P., Chambon P.
Trends.Biochem.Sci. 1992
; 17:427-433
.
Promoter context- and response element-dependent specificity of the transcriptional activation and modulating functions of retinoic acid receptors
Nagpal S., Saunders M., Kastner P., Durand B., Nakshatri H., Chambon P.
Cell 1992
; 70:1007-1019
.
Mechanisms of IFN-gamma induction by natural killer cell stimulatory factor (NKSF/IL-12). Role of transcription and mRNA stability in the synergistic interaction between NKSF and IL-2
Chan S.H., Kobayashi M., Santoli D., Perussia B., Trinchieri G.
J Immunol Jan. 1, 1992
; 148:92-8
.
Structure, localization and transcriptional properties of two classes of retinoic acid receptor alpha fusion proteins in acute promyelocytic leukemia (APL): structural similarities with a new family of oncoproteins
Kastner P., Perez A., Lutz Y., Rochette-Egly C., Gaub M.P., Durand B., Lanotte M., Berger R., Chambon P.
Embo J Feb 1992
; 11:629-42
.
Retinoid receptors and binding proteins
Lohnes D., Dierich A., Ghyselinck N., Kastner P., Lampron C., LeMeur M., Lufkin T., Mendelsohn C., Nakshatri H., Chambon P.
J Cell Sci Suppl 1992
; 16:69-76
.
Natural killer (NK) cell stimulatory factor or IL-12 has differential effects on the proliferation of TCR-alpha beta+, TCR-gamma delta+ T lymphocytes, and NK cells
Perussia B., Chan S.H., D'Andrea A., Tsuji K., Santoli D., Pospisil M., Young D., Wolf S.F., Trinchieri G.
J Immunol Dec. 1, 1992
; 149:3495-502
.
Retinoic acid receptor gene expression in human skin
Elder J.T., Fisher G.J., Zhang Q.Y., Eisen D., Krust A., Kastner P., Chambon P., Voorhees J.J.
J.Invest.Dermatol. 1991
; 96:425-433
.
Progestin receptors: isoforms and antihormone action
Gronemeyer H., Meyer M.E., Bocquel M.T., Kastner P., Turcotte B., Chambon P.
J.Steroid.Biochem.Mol.Biol. 1991
; 40:271-278
.
Retinoic acid nuclear receptors
Kastner P., Brand N., Krust A., Leroy P., Mendelsohn C., Petkovitch M., Zelent A., Chambon P.
Developmental patterning of the vertebrate limb. NATO ASI Series 1991
; :75-88
.
Transcriptional regulation of retinoic acid receptor beta in retinoic acid-sensitive and -resistant P19 embryocarcinoma cells
Kruyt F.A., van den Brink C.E., Defize L.H., Donath M.J., Kastner P., Kruijer W., Chambon P., van der Saag P.T.
Mech.Dev. 1991
; 33:171-178
.
Multiple isoforms of the mouse retinoic acid receptor alpha are generated by alternative splicing and differential induction by retinoic acid
Leroy P., Krust A., Zelent A., Mendelsohn C., Garnier J.M., Kastner P., Dierich A., Chambon P.
EMBO J. 1991
; 10:59-69
.
Differentially expressed isoforms of the mouse retinoic acid receptor beta generated by usage of two promoters and alternative splicing
Zelent A., Mendelsohn C., Kastner P., Krust A., Garnier J.M., Ruffenach F., Leroy P., Chambon P.
EMBO J. 1991
; 10:71-81
.
Induction of interferon gamma production by natural killer cell stimulatory factor: characterization of the responder cells and synergy with other inducers
Chan S.H., Perussia B., Gupta J.W., Kobayashi M., Pospisil M., Young H.A., Wolf S.F., Young D., Clark S.C., Trinchieri G.
J Exp Med April 1, 1991
; 173:869-79
.
[Fusion proteins between PML and alpha-RAR in acute promyelocytic leukemia]
Kastner P., Perez A., Lutz Y., Rochette-Egly C., Gaub M.P., Chambon P.
C R Seances Soc Biol Fil 1991
; 185:391-401
.
Transient expression of human and chicken progesterone receptors does not support alternative translational initiation from a single mRNA as the mechanism generating two receptor isoforms.
Kastner P., Bocquel M.T., Turcotte B., Garnier J.M., Horwitz K.B., Chambon P., Gronemeyer H.
J.Biol.Chem. 1990
; 265:12163-12167
.
Murine isoforms of retinoic acid receptor gamma with specific patterns of expression
Kastner P., Krust A., Mendelsohn C., Garnier J.M., Zelent A., Leroy P., Staub A., Chambon P.
Proc.Natl.Acad.Sci.U.S.A. 1990
; 87:2700-2704
.
Two distinct estrogen-regulated promoters generate transcripts encoding the two functionally different human progesterone receptor forms A and B
Kastner P., Krust A., Turcotte B., Stropp U., Tora L., Gronemeyer H., Chambon P.
EMBO J. 1990
; 9:1603-1614
.
Differential expression of genes encoding alpha, beta and gamma retinoic acid receptors and CRABP in the developing limbs of the mouse
Dolle P., Ruberte E., Kastner P., Petkovich M., Stoner C.M., Gudas L.J., Chambon P.
Nature 1989
; 342:702-705
.
A third human retinoic acid receptor, hRAR-gamma
Krust A., Kastner P., Petkovich M., Zelent A., Chambon P.
Proc.Natl.Acad.Sci.U.S.A. 1989
; 86:5310-5314
.
Regulation of progesterone receptor mRNA by oestradiol and antioestrogens in breast cancer cell lines
May F.E., Johnson M.D., Wiseman L.R., Wakeling A.E., Kastner P., Westley B.R.
J.Steroid.Biochem. 1989
; 33:1035-1041
.
Cloning of murine alpha and beta retinoic acid receptors and a novel receptor gamma predominantly expressed in skin
Zelent A., Krust A., Petkovich M., Kastner P., Chambon P.
Nature 1989
; 339:714-717
.
Identification and purification of natural killer cell stimulatory factor (NKSF), a cytokine with multiple biologic effects on human lymphocytes
Kobayashi M., Fitz L., Ryan M., Hewick R.M., Clark S.C., Chan S., Loudon R., Sherman F., Perussia B., Trinchieri G.
J Exp Med Sept. 1, 1989
; 170:827-45
.