IGBMC : Institut de la Génétique et de la Biologie Moléculaire et Cellulaire

• Chercheurs

  Irwin DAVIDSON

  Gabriel MALOUF

  Igor MARTIANOV

  Gabrielle MENGUS

• Post-Doctorants

  Anas FADLOUN

• Doctorants

  Sébastien COASSOLO

  Giovanni GAMBI

  Thomas KLEIBER

  Bujamin VOKSHI

• Ingénieurs & Techniciens

  Youenn DAVIDSON

  Isabelle MICHEL

• Collaborateur Occasionnel

  Alexandre BLAIS

Génomique fonctionnelle et cancer

Régulation de l’expression génique et cancer

Publications

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• Tif1gamma is essential for the terminal differentiation of mammary alveolar epithelial cells and for lactation through SMAD4 inhibition.

  Hesling C(1), Lopez J, Fattet L, Gonzalo P, Treilleux I, Blanchard D, Losson R, Goffin V, Pigat N, Puisieux A, Mikaelian I, Gillet G, Rimokh R.

  Development 1 janvier 2013;140:167-75.

• Hypoxia induces phenotypic plasticity and therapy resistance in melanoma via the tyrosine kinase receptors ROR1 and ROR2.

  O'Connell MP(1), Marchbank K, Webster MR, Valiga AA, Kaur A, Vultur A, Li L, Herlyn M, Villanueva J, Liu Q, Yin X, Widura S, Nelson J, Ruiz N, Camilli TC, Indig FE, Flaherty KT, Wargo JA, Frederick DT, Cooper ZA, Nair S, Amaravadi RK, Schuchter LM, Karakousis GC, Xu W, Xu X, Weeraratna AT.

  Cancer Discov Dec 2013;3:1378-93.

• Sumoylation at chromatin governs coordinated repression of a transcriptional program essential for cell growth and proliferation.

  Neyret-Kahn H(1), Benhamed M, Ye T, Le Gras S, Cossec JC, Lapaquette P, Bischof O, Ouspenskaia M, Dasso M, Seeler J, Davidson I, Dejean A.

  Genome Res Oct 2013;23:1563-79.

• Trim24-repressed VL30 retrotransposons regulate gene expression by producing noncoding RNA.

  Herquel B, Ouararhni K, Martianov I, Le Gras S, Ye T, Keime C, Lerouge T, Jost B, Cammas F, Losson R, Davidson I.

  Nat Struct Mol Biol Mar 2013;20:339-46.

• MITF, the Janus transcription factor of melanoma.

  Koludrovic D, Davidson I.

  Future Oncol Feb 2013;9:235-44.

• Cdx2 determines the fate of postnatal intestinal endoderm.

  Stringer EJ(1), Duluc I, Saandi T, Davidson I, Bialecka M, Sato T, Barker N, Clevers H, Pritchard CA, Winton DJ, Wright NA, Freund JN, Deschamps J, Beck F.

  Development Feb 2012;139:465-74.

• Phosphorylation of BRN2 modulates its interaction with the Pax3 promoter to control melanocyte migration and proliferation.

  Berlin I(1), Denat L, Steunou AL, Puig I, Champeval D, Colombo S, Roberts K, Bonvin E, Bourgeois Y, Davidson I, Delmas V, Nieto L, Goding CR, Larue L.

  Mol Cell Biol Apr 2012;32:1237-47.

• Tif1gamma suppresses murine pancreatic tumoral transformation by a Smad4-independent pathway.

  Vincent DF(1), Gout J, Chuvin N, Arfi V, Pommier RM, Bertolino P, Jonckheere N, Ripoche D, Kaniewski B, Martel S, Langlois JB, Goddard-Léon S, Colombe A, Janier M, Van Seuningen I, Losson R, Valcourt U, Treilleux I, Dubus P, Bardeesy N, Bartholin L.

  Am J Pathol Jun 2012;180:2214-21.