IGBMC : Institut de la Génétique et de la Biologie Moléculaire et Cellulaire

• Chercheurs

  Pierre CHAMBON

  Delphine DUTEIL

  Gilles LAVERNY

  Daniel METZGER

• Post-Doctorants

  Daniela ROVITO

• Doctorants

  Rana EL BIZRI

  Elise GRELET

  Anna-Isavella RERRA

• Ingénieurs & Techniciens

  Jean-Marc BORNERT

  Catherine COQUARD BOURDONET

  Laetitia PAULEN

• Master

  Khalil BEN RAYANA

Génomique fonctionnelle et cancer

Rôles physiopathologiques des voies de signalisation des récepteurs nucléaires

Publications

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• Nur77 deletion impairs muscle growth during developmental myogenesis and muscle regeneration in mice.

  Cortez-Toledo O(1), Schnair C(1), Sangngern P(1), Metzger D(2), Chao LC(1,)(3).

  PLoS One 7 février 2017;12:e0171268.

• Similarities and differences in the transcriptional control of expression of the mouse TSLP gene in skin epidermis and intestinal epithelium.

  Ganti KP(1,)(2,)(3), Mukherji A(1,)(2,)(3), Surjit M(1,)(2,)(3,)(4), Li M(1,)(2), Chambon P(5,)(2,)(3).

  Proc Natl Acad Sci U S A 7 février 2017;114:E951-E960.

• Effect of constitutive inactivation of the myostatin gene on the gain in muscle strength during postnatal growth in two murine models.

  Stantzou A(1), Ueberschlag-Pitiot V(2), Thomasson R(3), Furling D(4), Bonnieu A(5), Amthor H(1), Ferry A(4,)(6).

  Muscle Nerve Feb 2017;55:254-261.

• Mutations in the ERCC2 (XPD) gene associated with severe fetal ichthyosis and dysmorphic features.

  Miguet M(1), Thevenon J(2,)(3), Laugel V(4,)(5), Lefebvre M(2), Bourchany A(2), Riviere JB(3,)(6), Duffourd Y(3,)(6), Schaefer E(1), Antal MC(7), Abida R(8), Weingertner AS(9), Kremer V(10), Vabres P(3,)(11), Morice-Picard F(12), Gonzales M(13), Lipsker D(14), Fraitag S(15), Mandel JL(16), Chelly J(16), Dollfus H(1,)(5), Faivre L(2,)(3), Thauvin-Robinet C(2,)(3), Calmels N(16), El Chehadeh S(1).

  Prenat Diagn Dec 2016;36:1276-1279.

• Guanine nucleotide exchange factor RABGEF1 regulates keratinocyte-intrinsic signaling to maintain skin homeostasis.

  Marichal T, Gaudenzio N, El Abbas S, Sibilano R, Zurek O, Starkl P, Reber LL, Pirottin D, Kim J, Chambon P, Roers A, Antoine N, Kawakami Y, Kawakami T, Bureau F, Tam SY, Tsai M, Galli SJ.

  J Clin Invest 1 décembre 2016;126:4497-4515.

• Muscle expression of a malonyl-CoA-insensitive carnitine palmitoyltransferase-1 protects mice against high-fat/high-sucrose diet-induced insulin resistance.

  Vavrova E(1), Lenoir V(2), Alves-Guerra MC(2), Denis RG(3), Castel J(3), Esnous C(2), Dyck JR(4), Luquet S(3), Metzger D(5), Bouillaud F(2), Prip-Buus C(6).

  Am J Physiol Endocrinol Metab 1 septembre 2016;311:E649-60.

• Transcription factor TBX4 regulates myofibroblast accumulation and lung fibrosis.

  Xie T, Liang J, Liu N, Huan C, Zhang Y, Liu W, Kumar M, Xiao R, D'Armiento J, Metzger D, Chambon P, Papaioannou VE, Stripp BR, Jiang D, Noble PW.

  J Clin Invest 1 septembre 2016;126:3626.

• Insulin receptor isoform A ameliorates long-term glucose intolerance in diabetic mice.

  Diaz-Castroverde S(1,)(2,)(3), Gomez-Hernandez A(1,)(2), Fernandez S(1,)(2), Garcia-Gomez G(1,)(2), Di Scala M(4), Gonzalez-Aseguinolaza G(4), Fernandez-Millan E(1,)(2,)(3), Gonzalez-Rodriguez A(5,)(6), Garcia-Bravo M(7), Chambon P(8), Alvarez C(1,)(2,)(3), Perdomo L(1), Beneit N(1), Escribano O(9,)(2,)(3), Benito M(1,)(2,)(3).

  Dis Model Mech 1 novembre 2016;9:1271-1281.