The Team

Functional genomics and cancer

Nuclear retinoic acid receptors phosphorylation and cross-talk with signaling pathways

We work at the interface of cellular and molecular biology focusing on retinoic acid, the active metabolite of vitamin A, which controls cell proliferation and differentiation through nuclear receptors. These receptors, RARs, work as ligand-dependent transcriptional regulators but complexity came with the finding that RARs are targets for post-translational modifications such as phosphorylations, which turned out to be crucial for their transcriptional activity. Our goal is to dissect the mechanisms and consequences of RARs phosphorylation. We analyze how phosphorylation controls the dynamics of RAR-target genes? transcription. We also focus on how phosphorylation interferes with ubiquitination for RARs transcriptional activity and degradation. Given that many tumoral processes are characterized by aberrant kinase signaling pathways, we are engaged in a large analysis of RARs phosphorylation in cancer cell lines and tumor samples in correlation with their sensitivity to retinoic acid. The final important focus of our studies is to define how phosphorylation controls the activity of RARs during cell differentiation and embryonic development.

Imprimer Envoyer

Université de Strasbourg

IGBMC - CNRS UMR 7104 - Inserm U 1258
1 rue Laurent Fries / BP 10142 / 67404 Illkirch CEDEX / France Tél +33 (0)3 88 65 32 00 / Fax +33 (0)3 88 65 32 01 /