IGBMC : Institut de la Génétique et de la Biologie Moléculaire et Cellulaire

• Chercheurs

  Robert DRILLIEN

  Valérie LAMOUR

  Marc RUFF

• Post-Doctorants

  Eduardo BRUCH

• Doctorants

  Christophe LOTZ

  Arnaud VANDEN BROECK

• Ingénieurs & Techniciens

  Julien BATISSE

  Sylvia EILER

• Collaborateur Occasionnel

  Nicolas LEVY

• Stagiaire

  Allan BERTRAND

Biologie structurale intégrative

Stabilité de la chromatine et mobilité de l'ADN

Publications

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• Unstable Protein Purification Through the Formation of Stable Complexes.

  Eiler S(1), Levy N(1), Maillot B(1), Batisse J(1), Aubreton KP(1), Oladosu O(1), Ruff M(2).

  Methods Mol Biol 2018;1764:315-328.

• Structure-function analyses unravel distinct effects of allosteric inhibitors of HIV-1 integrase on viral maturation and integration.

  Bonnard D(1), Le Rouzic E(2), Eiler S(3), Amadori C(2), Orlov I(3), Bruneau JM(2), Brias J(2), Barbion J(2), Chevreuil F(2), Spehner D(3), Chasset S(2), Ledoussal B(2), Moreau F(2), Saib A(4), Klaholz BP(3), Emiliani S(5), Ruff M(3), Zamborlini A(4), Benarous R(2).

  J Biol Chem 5 mars 2018.

• Structural features of the salivary gland hypertrophy virus of the tsetse fly revealed by cryo-electron microscopy and tomography.

  Orlov I(1), Drillien R(2), Spehner D(3), Bergoin M(4), Abd-Alla AMM(5), Klaholz BP(6).

  Virology 15 janvier 2018;514:165-169.

• Modulation of the functional association between the HIV-1 intasome and the nucleosome by histone amino-terminal tails.

  Benleulmi MS(1)(2), Matysiak J(1)(2), Robert X(3), Miskey C(4), Mauro E(1)(2), Lapaillerie D(1)(2)(5), Lesbats P(1)(2), Chaignepain S(6), Henriquez DR(7), Calmels C(1)(2)(5), Oladosu O(8), Thierry E(9), Leon O(7), Lavigne M(10)(11)(5), Andreola ML(1)(2)(5), Delelis O(9)(5), Ivics Z(4), Ruff M(8)(5), Gouet P(3)(5), Parissi V(12)(13)(14).

  Retrovirology 28 novembre 2017;14:54.

• The HIV-1 integrase-LEDGF allosteric inhibitor MUT-A: resistance profile, impairment of virus maturation and infectivity but without influence on RNA packaging or virus immunoreactivity.

  Amadori C(1)(2)(3)(4), van der Velden YU(5), Bonnard D(1), Orlov I(6), van Bel N(5), Le Rouzic E(1), Miralles L(7), Brias J(1), Chevreuil F(1), Spehner D(6), Chasset S(1), Ledoussal B(1), Mayr L(8), Moreau F(1), Garcia F(7), Gatell J(7), Zamborlini A(9), Emiliani S(2)(3)(4), Ruff M(6), Klaholz BP(6), Moog C(8), Berkhout B(10), Plana M(11), Benarous R(12)(13).

  Retrovirology 9 novembre 2017;14:50.

• Modulation of chromatin structure by the FACT histone chaperone complex regulates HIV-1 integration.

  Matysiak J(1)(2), Lesbats P(1)(2), Mauro E(1)(2), Lapaillerie D(1)(2)(3), Dupuy JW(4), Lopez AP(5), Benleulmi MS(1)(2)(3), Calmels C(1)(2)(3), Andreola ML(1)(2)(3), Ruff M(6), Llano M(5), Delelis O(7)(3), Lavigne M(8)(9)(3), Parissi V(10)(11)(12).

  Retrovirology 28 juillet 2017;14:39.

• A User-Friendly DNA Modeling Software for the Interpretation of Cryo-Electron Microscopy Data.

  Lariviere D(1), Galindo-Murillo R(2), Fourmentin E(3), Hornus S(4), Levy B(4), Papillon J(5), Menetret JF(5), Lamour V(6)(7).

  Methods Mol Biol 2017;1624:193-210.

• A no-stop mutation in MAGEB4 is a possible cause of rare X-linked azoospermia and oligozoospermia in a consanguineous Turkish family.

  Okutman O(1)(2)(3), Muller J(4)(5), Skory V(1), Garnier JM(6), Gaucherot A(7), Baert Y(8), Lamour V(9), Serdarogullari M(10), Gultomruk M(10), Ropke A(11), Kliesch S(12), Herbepin V(13), Aknin I(14), Benkhalifa M(15), Teletin M(1), Bakircioglu E(16), Goossens E(8), Charlet-Berguerand N(7), Bahceci M(10), Tuttelmann F(11), Viville S(17)(18)(19)(20).

  J Assist Reprod Genet May 2017;34:683-694.