Integrative Analyses of Gene Expression and the Epigenome

Integrative Analyses of Gene Expression and the Epigenome

Full understanding of the complexity of eukaryotic gene expression regulatory mechanisms requires a detailed analysis of the structural organization and of the dynamics of the large molecular machines involved in transcription, post-transcriptional RNA processing and translation. Towards this aim, integration of functional, dynamic, genomic and structural approaches is essential to fully characterize transcriptional activators and their cofactors, complexes involved in chromatin modification and assembly, chromatin architecture, non-coding RNA, RNA metabolism and protein biosynthesis.

IGBMC has a unique, long-standing, and ever-growing expertise in this research field where specific collaborative work between different IGBMC teams has demonstrated the importance of setting up integrative studies to obtain novel, cutting-edge results with high impact at the international level. To build on this dynamic, the transversal program « Integrative analyses of Gene Expression and the Epigenome » has been launched to reinforce, and, more importantly, to promote collaborations between groups working on integrative approaches on gene expression.

This synergistic approach, as a strategic priority for IGBMC, will address mechanisms of gene expression ranging from structure to function. A full description of the structural and the dynamic properties of biological processes are essential, not only to understand the genetic and epigenetic basis of diseases like cancer, but also to conceive new pharmaceutical drug-leads. The objectives of this transversal program are to integrate multiple technologies to investigate the different levels of spatial and temporal organization that regulate biological systems from the atomic level to the complete organism.

To achieve this, the teams participating to the transversal program need to investigate regulatory networks, combinatorial effects of transcription factors, collective chromatin behavior, and complex interactomes. Tackling these systems biology issues requires multiple integrative techniques from multi-scale structural approaches, imaging and high-throughput sequencing techniques combined with biocomputing analyses, going from cell cultures to simple and complex animal models, and by fostering new technological developments at the interfaces driven by the biological questions of interest.

Imprimer Envoyer

Université de Strasbourg

IGBMC - CNRS UMR 7104 - Inserm U 1258
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