IGBMC : Institut de la Génétique et de la Biologie Moléculaire et Cellulaire

• Researchers

  Daniel RIVELINE

• PhD Students

  Alka BHAT

  Simon LO VECCHIO

  Linjie LU

• Engineers & Technicians

  Michèle LIEB

• Master

  Tristan GUYOMAR

Development and stem cells

Cell physics

Cells are traditionally viewed as a soup of chemical reactions. However cell shape is also the result of self-assembly phenomena; the physical laws of matter provide the appropriate framework for understanding shapes of cells and tissues. Within the cells, the cytoskeleton dynamics and its associated Rho pathways give the proper unit for understanding cell motility, cell division and cell shapes within tissues. We use interdisciplinary approaches to address these phenomena in cell culture. The physical framework is inspired from soft matter physics. The biological side is adapted from cell biology for changing specifically cell shapes with cytoskeleton drugs, genetic modifications, and mechanical constraints. The chemical part consists in designing new agents for altering cell motility and cell division. In the long term, our research may provide new ideas for understanding cancer.
Being interdisciplinary in nature, our group is located both at The Science and Supramolecular Engineering Institute in Strasbourg for the physical/chemical themes as well as at the IGBMC for those of cell biology. We use classical cell lines for fibroblasts and epithelium, along with fission yeast as a model system for cytokinesis. Microfabrication plays a key role for our measurements of forces, as well as for ordering cells in our experiments. A start-up, RingTech, is curently  incubated by Sémia, the alsatian incubator.

Team website

• Current projects

  As prototypes of organs derived in the lab from stem cells, organoids are a growing subject of study, with revolutionary perspectives in research and medicine.

   

  The prestigious Program Grant Award of the Human Frontier Science Program (HFSP) selected for funding the project carried out by Daniel Riveline, researcher at IGBMC, in international collaboration with three researchers (Alf Honigmann (Max Planck Institute, Dresden), Anne Grapin-Botton (Center for Stem Cell Biology, University of Copenhagen) and Masaki Sano (Dept. of Physics, The University of Tokyo)) to study the phenomena of cellular self-organization in organoids.

   

  This ambitious project aims to study the mechanisms of organoid formation. Using cellular models generating neuroepithelial and pancreatic structures, this research will aim to understand how these organs emerge from stem cells. It will involve over time and in close synergies several fields, cell physics, theoretical physics, cell biology, development biology, microfabrication and super-resolution microscopy.

• Collaborations

• Prizes/Awards

  • Daniel RIVELINE - Foundation Simone and Cino del Duca Prize - Institut de France de l'Académie des Sciences - 2011
  • Daniel RIVELINE - ATIP starting grant - CNRS - 2010
  • Daniel RIVELINE - Nine Choucroun Prize - Institut de Biologie Physico-Chimique de Paris - 1998

• News

  • July 1, 2016 - Cell division: how molecular motors team up for separating cells
  • Nov. 24, 2015 - Ratchetaxis: a new way how cells move
  • July 29, 2013 - New synthetic molecules target actin cytoskeleton

• Publications

  • Directing cell migration on flat substrates and in confinement with microfabrication and microfluidics.

    Le Maout E(1), Lo Vecchio S(1), Bhat A(1), Riveline D(2).

    Methods Cell Biol 2018 ; 147:109-132 .

  • Active bundles of polar and bipolar filaments.

    Kreten FH(1), Hoffmann C(1), Riveline D(2), Kruse K(3).

    Phys Rev E Jul 2018 ; 98:012413 .

  • The Science of Living Matter for Tomorrow.

    Bauer G(1), Fakhri N(2), Kicheva A(3), Kondev J(4), Kruse K(5), Noji H(6), Riveline D(7), Saunders TE(8), Thattai M(9), Wieschaus E(10).

    Cell Syst April 25, 2018 ; 6:400-402 .

  • Spatial Fluctuations at Vertices of Epithelial Layers: Quantification of Regulation by Rho Pathway.

    Fodor E(1), Mehandia V(2), Comelles J(3), Thiagarajan R(3), Gov NS(4), Visco P(5), van Wijland F(5), Riveline D(6).

    Biophys J Feb. 27, 2018 ; 114:939-946 .

  • HMP-1/alpha-catenin promotes junctional mechanical integrity during morphogenesis.

    Vuong-Brender TTK(1)(2), Boutillon A(1), Rodriguez D(2), Lavilley V(2), Labouesse M(1)(2).

    PLoS One Feb. 21, 2018 ; 13:e0193279 .

  • Clinical, Biomarker, and Molecular Delineations and Genotype-Phenotype Correlations of Ataxia With Oculomotor Apraxia Type 1.

    Renaud M(1)(2)(3), Moreira MC(2), Ben Monga B(4), Rodriguez D(5)(6)(7)(8), Debs R(9), Charles P(9), Chaouch M(10), Ferrat F(11), Laurencin C(12)(13), Vercueil L(14)(15), Mallaret M(14), M'Zahem A(16), Pacha LA(17), Tazir M(17), Tilikete C(18), Ollagnon E(19), Ochsner F(20), Kuntzer T(20), Jung HH(21), Beis JM(22), Netter JC(23), Djamshidian A(24), Bower M(25), Bottani A(26), Walsh R(27)(28), Murphy S(28), Reiley T(29), Bieth E(30), Roelens F(31), Poll-The BT(32), Lourenco CM(33), Jardim LB(34), Straussberg R(35)(36), Landrieu P(37), Roze E(9), Thobois S(12)(13), Pouget J(38), Guissart C(39), Goizet C(40)(41), Durr A(9), Tranchant C(1)(2)(3), Koenig M(39), Anheim M(1)(2)(3).

    JAMA Neurol April 1, 2018 ; 75:495-502 .

  • An Arf6- and caveolae-dependent pathway links hemidesmosome remodeling and mechanoresponse.

    Osmani N(1)(2)(3)(4)(5), Pontabry J(1)(3), Comelles J(1)(3)(6), Fekonja N(2)(3)(4)(5), Goetz JG(2)(3)(4)(5), Riveline D(7)(3)(6), Georges-Labouesse E(1)(3), Labouesse M(7)(3)(8).

    Mol Biol Cell Feb. 15, 2018 ; 29:435-451 .

  • 'The Forms of Tissues, or Cell-aggregates': D'Arcy Thompson's influence and its limits.

    Graner F(1), Riveline D(2)(3)(4)(5)(6).

    Development Dec. 1, 2017 ; 144:4226-4237 .

  • Interface between Physics and Biology: Training a New Generation of Creative Bilingual Scientists.

    Riveline D(1), Kruse K(2).

    Trends Cell Biol Aug 2017 ; 27:541-543 .

  • Ordering Single Cells and Single Embryos in 3D Confinement: A New Device for High Content Screening.

    Wollrab V(1), Caballero D(1), Thiagarajan R(1), Riveline D(2).

    J Vis Exp Sept. 18, 2016 ; 115:51880 .

  See all publications=>

• Job opportunities

• Alumni

• Videos

• Thesis subjects

  • Interplay Between Signaling And Mechanics In Epithelia: Morphogenesis In Vitro (H/F)
  • Coupling Of Cell Polarization And Differentiation In Organoids (H/F)
  • Position Coupling Of Cell Polarization And Differentiation In Organoids (H/F)