László Tora, winner of the 2013 ERC Advanced Grant
Dec. 1, 2013
Every year, talented researchers across Europe are distinguished by the European Research Council (ERC). Since its creation in 2007, nearly 4000 research projects conducted by young or more experienced researchers have benefited from the financial support of the ERC. With a success rate of about 12 % for the life sciences projects this year, the selection of laureate is particularly elitist. László Tora won a ERC Advanced Grant 2013, bringing to 11 the number of researchers at the IGBMC having an ERC grant.
After Michel Labouesse and Marat Yusupov in 2011, it was the turn of László Tora to be the laureate of the European Research Council (ERC) Advanced Grant 2013. László Tora is one of 104 team leaders selected among 788 candidates in the life sciences. With 2.5 million euros grant spread over five years, this prestigious funding will allow him to implement its BIRTOACTION project which aims to analyze the processes of gene regulation through the biogenesis of transcription complexes.
Established in 2007, the European Research Council is the first pan-European funding organization for research which aims to stimulate scientific excellence in Europe. The ERC Advanced Grants are intended for established players of research in Europe, with an exceptional career. Reviewed by an international panel of renowned scientists, candidacies are evaluated on their scientific excellence as the sole criterion. The scientific projects selected are highly innovative and likely to bring new perspectives to the scientific community in their own field or as a whole.
Led by László Tora and his colleague Didier Devys at the IGBMC, the BIRTOACTION project aims to study the biogenesis of transcription complexes. Transcription is the first of a long series of steps allowing the passage from gene to protein. This process requires the interaction of many molecular players, most of which are multiprotein complexes that need to be assembled from different subunits. Several studies suggest that there is a decision-making at the cellular level that governs the assembly and localization of these actors, and thus regulating gene expression. The aim of the project "BIRTOACTION" is to uncover the mechanisms that control the synthesis, assembly and activity of key molecular players in transcription of DNA in the nuclei of cells. Through a multidisciplinary approach and the use of advanced technology, the researchers hope to bring new elements for the understanding of gene regulation processes.