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New function for Argonaute proteins

Argonaute proteins couple chromatin silencing to alternative splicing.

Ameyar-Zazoua M, Rachez C, Souidi M, Robin P, Fritsch L, Young R, Morozova N, Fenouil R, Descostes N, Andrau JC, Mathieu J, Hamiche A, Ait-Si-Ali S, Muchardt C, Batsché E, Harel-Bellan A.

Nat Struct Mol Biol Oct 2012

Sept. 9, 2012

Already known for their role in RNA interference, Argonaute proteins also regulate another process that affects gene expression: alternative splicing. This is what researchers from the Laboratory “Epigenetics and Cancer” (CNRS/CEA) and the laboratory “Genetic, molecular and cellular basis of development” (Institut Pasteur/CNRS) have brought to the light. This result published in Nature Structural & Molecular Biology has been obtained in collaboration with the Center of Immunology of Marseille-Luminy (CNRS/Inserm/Université Aix-Marseille), the Institut des hautes études scientifiques and Ali Hamiche's team from the IGBMC.

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