IGBMC : Institut de la Génétique et de la Biologie Moléculaire et Cellulaire

Technology platforms

Bioinformatics

Situated at the interface between biology, I.T. and statistics, the platform aims to provide a bioinformatics support to research laboratories’ projects. From automated protein and nucleic acid sequence comparisons, software and database development, to "omics" data analysis, the platform brings solutions to modern biology’s information treatment problems.

• Bioinformatics Platform official website

• Current projects

• Collaborations

  - Hélène Dollfus (Laboratoire Physiopathologie des syndromes rares héréditaires, Strasbourg)  : « Classification des variants génétiques issus du séquençage haut débit »
  - Jean MULLER (IGBMC, LBGI) : « Classification des variants génétiques issus du séquençage haut débit »
  - Dr. Isabelle Robert et Dr Bernardo Reina-San-Martin (Equipe de biologie moléculaire des cellules B, Département de génomique fonctionnelle et cancer, IGBMC) : IgCSRTool
  - Dr. Olivier Poch (Laboratoire de Bioinformatique et Génomique Intégrative, IGBMC) : Infidélité de la transcription dans le cancer
  - Dr. Julien Vermot (Biologie du développement et cellules souches, IGBMC): RNA-seq Brachydanio rerio
  - Prof. David Y. Thomas (Université McGill, Montréal, Québec, Canada): Molécules correctrices du mutant ΔF-508 CFTR
   
  
  

• Prizes/Awards

• News

• Publications

  • Identification of an Alternative Splicing Product of the Otx2 Gene Expressed in the Neural Retina and Retinal Pigmented Epithelial Cells.

    Kole C(1,)(2,)(3), Berdugo N(1,)(2,)(3), Da Silva C(4), Aït-Ali N(1,)(2,)(3), Millet-Puel G(1,)(2,)(3), Pagan D(1,)(2,)(3), Blond F(1,)(2,)(3), Poidevin L(5), Ripp R(6), Fontaine V(1,)(2,)(3), Wincker P(4), Zack DJ(7), Sahel JA(1,)(2,)(3), Poch O(5), Léveillard T(1,)(2,)(3).

    PLoS One March 17, 2016

  • Efficient strategy for the molecular diagnosis of intellectual disability using targeted high-throughput sequencing.

    Redin C(1), Gérard B(2), Lauer J(2), Herenger Y(2), Muller J(3), Quartier A(1), Masurel-Paulet A(4), Willems M(5), Lesca G(6), El-Chehadeh S(4), Le Gras S(7), Vicaire S(7), Philipps M(7), Dumas M(7), Geoffroy V(8), Feger C(7), Haumesser N(1), Alembik Y(9), Barth M(10), Bonneau D(10), Colin E(10), Dollfus H(11), Doray B(9), Delrue MA(12), Drouin-Garraud V(13), Flori E(9), Fradin M(14), Francannet C(15), Goldenberg A(13), Lumbroso S(16), Mathieu-Dramard M(17), Martin-Coignard D(18), Lacombe D(12), Morin G(17), Polge A(16), Sukno S(19), Thauvin-Robinet C(4), Thevenon J(4), Doco-Fenzy M(20), Genevieve D(5), Sarda P(5), Edery P(6), Isidor B(21), Jost B(7), Olivier-Faivre L(4), Mandel JL(22), Piton A(1).

    J Med Genet Nov 2014

  • Rfx6 is an Ngn3-dependent winged helix transcription factor required for pancreatic islet cell development

    Soyer J., Flasse L., Raffelsberger W., Beucher A., Orvain C., Peers B., Ravassard P., Vermot J., Voz M.L., Mellitzer G., Gradwohl G.

    Development 2010 2010

  • Multidimensional fitting for multivariate data analysis

    Berge C., Froloff N., Kalathur R.K., Maumy M., Poch O., Raffelsberger W., Wicker N.

    J Comput Biol May 2010

  • The disruption of the rod-derived cone viability gene leads to photoreceptor dysfunction and susceptibility to oxidative stress

    Cronin T., Raffelsberger W., Lee-Rivera I., Jaillard C., Niepon M.L., Kinzel B., Clerin E., Petrosian A., Picaud S., Poch O., Sahel J.A., Leveillard T.

    Cell Death Differ Jul 2010

  • [START domain-containing proteins: a review of their role in lipid transport and exchange.]

    Alpy F., Legueux F., Bianchetti L., Tomasetto C.

    Med Sci (Paris) Feb 2009

  • Analysis of the retinal gene expression profile after hypoxic preconditioning identifies candidate genes for neuroprotection

    Thiersch M., Raffelsberger W., Frigg R., Samardzija M., Wenzel A., Poch O., Grimm C.

    BMC Genomics Feb. 8, 2008

  • RReportGenerator: automatic reports from routine statistical analysis using R

    Raffelsberger W., Krause Y., Moulinier L., Kieffer D., Morand A.L., Brino L., Poch O.

    Bioinformatics Jan. 15, 2008

  • ADCK3, an ancestral kinase, is mutated in a form of recessive ataxia associated with coenzyme Q10 deficiency

    Lagier-Tourenne C., Tazir M., Lopez L.C., Quinzii C.M., Assoum M., Drouot N., Busso C., Makri S., Ali-Pacha L., Benhassine T., Anheim M., Lynch D.R., Thibault C., Plewniak F., Bianchetti L., Tranchant C., Poch O., DiMauro S., Mandel J.L., Barros M.H., Hirano M., Koenig M.

    Am J Hum Genet Mar 2008

  • The hypoxic transcriptome of the retina: identification of factors with potential neuroprotective activity

    Thiersch M., Raffelsberger W., Frigg E., Samardzija M., Blank P., Poch O., Grimm C.

    Adv Exp Med Biol 2008

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