Epigenetics and cell fate in early mammalian development
Research in our group focuses on understanding how early mouse development is regulated by chromatin-mediated changes in gene regulation, that is, by epigenetic information. In particular, we are interested in understanding how the transitions in cell potency and cell fate are regulated by chromatin-mediated processes. We use the mouse embryo as a model because this is one of the few systems where it is possible to explore the foundations of totipotency and differentiation. Indeed, the zygote, which is the product of fertilization of an oocyte by sperm, has an inherent capacity to form all cell types in an organism. Chromatin-mediated changes in gene regulation have to ensure the plasticity required for undertaking such an essential task during development.Our projects will help us to understand how chromatin structure is progressively modified to restrict cell fate determination with the consequent loss of totipotency. Our work will also allow new insights in understanding the biology of the pluripotent stem cells, in particular on their origin and development. From a broader perspective, deciphering the basic mechanisms underlying the earliest steps of mammalian development is essential to understand early aspects of embryonic development, human reproduction and stem cell biology.
Our lab is part of the ‘Cellular signaling and nuclear dynamics’ programme”
If you are interested in joining the lab, please email directly to Maria-Elena Torres-Padilla email@example.com
- Maria Elena Torres Padilla - Member of the European Molecular Biology Organization (EMBO) - European Molecular Biology Organization (EMBO) - 2015
- Maria-Elena TORRES-PADILLA - Fondation Université de Strasbourg / Cercle Gutenberg prize 2014 - Cercle Gutenberg - 2015
- Maria-Elena TORRES-PADILLA - Scientific prize - Fondation Schlumberger pour l'Education et la Recherche (FSER) - 2014
- Maria Elena TORRES PADILLA - EMBO Young Investigator Award - European Molecular Biology Organization Young Investigator Programme (EMBO YIP) - 2011
- Maria-Elena TORRES PADILLA - ERC Starting grant - European Research Council (ERC) - 2011
- Maria-Elena TORRES-PADILLA - Scientific Prize - Comité Alsace de la Fondation pour la Recherche Médicale (FRM) - 2009
- Maria-Elena TORRES PADILLA - ATIP - AVENIR starting grant - Inserm / CNRS - 2009
- Maria-Elena TORRES PADILLA - Long-term fellowship - European Molecular Biology Organization (EMBO) - 2003
- Aug. 3, 2015 - From pluripotency to totipotency
- May 15, 2014 - Behind totipotency
- Nov. 15, 2013 - 3D nuclear organization of chromatin in the embryo after fertilization
- Oct. 31, 2013 - A new player inducing pluripotent cell fate in early development
- Oct. 6, 2013 - Visualizing the movements of genes in vivo
- Jan. 29, 2013 - The first days of an embryo and viral DNA resurgence
- Nov. 15, 2012 - Chromatin, an acute controller of cell cycle
- May 31, 2012 - A unified phylogeny-based nomenclature for histone variants
- Feb. 12, 2012 - Nanog : a dosage effect to regulate cell pluripotency
- Nov. 10, 2011 - Two junior researchers awarded by the prestigious european EMBO programme
- Aug. 1, 2010 - H3.3, a histone at the origin of development
Nature Sept. 14, 2016 ; 537:494-496 .
Dev Cell July 11, 2016 ; 38:3-5 .
Epigenetics Apr 15:1-9 2016 ; 11:289-297 .
Nat Biotechnol March 10, 2016 ; 34:270-5 .
Genes Dev March 15, 2016 ; 30:611-21 .
Chromosoma Mar 2016 ; 125:29-39 .
Cold Spring Harb Symp Quant Biol Nov. 18, 2015 ; 80:165-175 .
J Neurosci Oct. 28, 2015 ; 35:14467-75 .
Epigenetics Oct 19:0 2015 ; 11:553-562 .
Nat Struct Mol Biol Sep 2015 ; 22:662-71 .