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3'-5' RNA decay and effects on pathologies

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Teams
Members
Publications

3'-5' RNA decay and effects on pathologies

SUBGROUP LEADER

Eric HUNTZINGER

While the main mRNA decay pathway involves the 5’ to 3’ degradation of the mRNA body, 3’ to 5’ exonucleolytic mRNA trimming has been shown to play a major role for the elimination of defective, poorly translatable transcripts. Factors involved in the latter pathway are altered in a rare human genetic disease, underlining its importance. In this context, we are testing the role of these factors in pathological conditions. Moreover, we have identified new factors associated with 3’-5’ mRNA decay and are actively pursuing their characterization.

Teams

Eukaryotic mRNA decay
Team Leader : Bertrand SERAPHIN
Department : Executive management

Members

Researchers

Publications

2015
- Structure of the Elongator cofactor complex Kti11/Kti13 provides insight into the role of Kti13 in Elongator-dependent tRNA modification
  - Olga Kolaj-Robin
  - A Mcewen
  - Jean Cavarelli
  - Bertrand Séraphin
  FEBS Journal ; Volume: 282 ; Page: 819-833
  HAL DOI
2014
- The C-Terminal Domain from S. cerevisiae Pat1 Displays Two Conserved Regions Involved in Decapping Factor Recruitment
  - Zaineb Fourati
  - Olga A Kolesnikova
  - Régis Back
  - Jenny Keller
  - Clément Charenton
  - Valério Taverniti
  - Claudine Gaudon Plesse
  - Noureddine Lazar
  - Dominique Durand
  - Herman van Tilbeurgh
  - Bertrand Séraphin
  - Marc Graille
  PLoS ONE ; Volume: 9 ; Page: e96828
  HAL DOI
- Long open reading frame transcripts escape nonsense-mediated mRNA decay in yeast
  - Laurence Decourty
  - Antonia Doyen
  - Christophe Malabat
  - Emmanuel Frachon
  - Delphine Rispal
  - Bertrand Séraphin
  - Frank Feuerbach
  - Alain Jacquier
  - Cosmin Saveanu
  Cell Reports ; Volume: 6 ; Page: 593--598
  HAL DOI
- The C-Terminal Domain from S. cerevisiae Pat1 Displays Two Conserved Regions Involved in Decapping Factor Recruitment
  - Zaineb Fourati
  - Olga Kolesnikova
  - Régis Back
  - Jenny Keller
  - Clément Charenton
  - Valerio Taverniti
  - Claudine Plesse
  - Noureddine Lazar
  - Dominique Durand
  - Herman van Tilbeurgh
  - Bertrand Séraphin
  - Marc Graille
  PLoS ONE ; Volume: 9 ; Page: e96828
  HAL DOI
- Dom34-Hbs1 mediated dissociation of inactive 80S ribosomes promotes restart of translation after stress
  - A van den Elzen
  - A Schuller
  - R Green
  - Bertrand Séraphin
  EMBO Journal ; Volume: 33 ; Page: 265-276
  HAL DOI
- Quantification of pre-mRNA escape rate and synergy in splicing
  - Marie Mi Bonde
  - S Voegeli
  - A Baudrimont
  - Bertrand Séraphin
  - A Becskei
  Nucleic Acids Research ; Volume: 42 ; Page: 12847-12860
  HAL DOI
- A novel protein-protein interaction in the RES (REtention and Splicing) complex
  - K Tripsianes
  - A Friberg
  - C Barrandon
  - M Brooks
  - H van Tilbeurgh
  - Bertrand Séraphin
  - M Sattler
  Journal of Biological Chemistry ; Volume: 289 ; Page: 28640-28650
  HAL DOI
2013
- Identification of the Rps28 binding motif from yeast Edc3 involved in the autoregulatory feedback loop controlling RPS28B mRNA decay.
  - Olga Kolesnikova
  - Régis Back
  - Marc Graille
  - Bertrand Séraphin
  Nucleic Acids Research ; Volume: 41 ; Page: 9514-9523
  HAL DOI
- Identification of the Rps28 binding motif from yeast Edc3 involved in the autoregulatory feedback loop controlling RPS28B mRNA decay
  - Olga Kolesnikova
  - Régis Back
  - Marc Graille
  - Bertrand Séraphin
  Nucleic Acids Research ; Volume: 41 ; Page: 9514 - 9523
  HAL DOI
- Rapid screening of yeast mutants with reporters identifies new splicing phenotypes
  - Natacha Dreumont
  - Bertrand Séraphin
  FEBS Journal ; Volume: 280 ; Page: 2712-2726
  HAL DOI

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