Prix L'Oréal-UNESCO Pour les Femmes et la Science 2014 Fondation L'Oréal et l'UNESCO : Brigitte Kieffer Prix scientifique 2014 Fondation Schlumberger pour l'Education et la Recherche (FSER) : Maria-Elena TORRES-PADILLA
In mice with myotubular myopathy (MTM1), also named centronuclear myopathy due to the central position of nuclei, muscle fibers are smaller and unable to produce a normal muscle contraction (left). The decrease in dynamin (DNM2) reverts fiber size to normal and allows the correct positioning of muscle nuclei at the periphery (right).
Feb. 24, 2014
Using an innovative strategy, researchers at the IGBMC managed to cure an animal affected by centronuclear myopathy, also called myotubular myopathy. Through a gene modulation approach, J. Laporte’s team observed an almost total disappearance of clinical signs of this rare disease. In addition to the therapeutic potential they give rise to, these results shed a new light on the mechanisms involved in Centronuclear myopathies. This study is published 24 February 2014 in the Journal of Clinical Investigation.
March 3, 2014
Every year since 1998, the UNESCO and L'Oréal Corporate Foundation rewards 5 women, one per continent, for their contribution to the advancement of Science and career in a field still largely dominated by men. For the 2014 awards, life sciences are being celebrated.
The binding of ANP32E to H2A.Z (red) induces a significant conformational change of the helix αC of H2A.Z whose length is doubled (purple). This change has a major effect in destabilizing the binding of H2A.Z to the H3/H4 (blue/yellow) histone pair within the nucleosome, most likely causing the eviction of the H2A.Z/H2B pair from chromatin.
Jan. 22, 2014
The team of Dr. Ali HAMICHE (IGBMC), in collaboration with Drs. Christophe ROMIER (IGBMC), Stefan Dimitrov (IAL, Grenoble) and Tak MAK (UHN, Toronto, Canada) has identified a new mechanism of regulation of gene expression. This is the first example showing at a molecular level the relief of the inhibition of a promoter through a specific histone removal. Their results are published on January 22nd in the journal Nature.
3D reconstruction of a cilium internal architecture.
Feb. 20, 2014
From bacteria to mammals, cell cilia are essential structures for life. However, their role is often poorly understood. Thanks to an innovative imaging technique, the team of Julien Vermot at the IGBMC could visualize in real time the role of endothelial cilia during the development of the vascular system in zebrafish. They measured the forces driving the deformation of cilia in the blood vessels and were able to reconstruct the three-dimensional internal structure of a cilium. In this new study, the researchers show that the cilia of endothelial cells play a central role in the development of the vascular system. This work is published on 20 February 2014 in the journal Cell Reports.