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Model of signal transduction propagation and gene regulatory networks involved in cell differentiation after retinoic acid treatment. The starting node where the initial cue activates the signal transduction is depicted, as well as the downstream node interconnections required for its propagation. The temporal transcriptional state for each gene (node) is defined as 1, 0 or -1 (up-regulated, non-responsive or down-regulated respectively).
Sept. 20, 2016
By using the integration of multiple functional genomic read-outs, Hinrich Gronemeyer’s team has modeled stem cell fate through the reconstruction of gene regulatory networks involved in this process.
In this work published on September 20th in Genome Research, the authors achieved to modify cell fate by activating some key genes identified through computational modeling. Such integrative approach will surely generate valuable predictions for regenerative medecine.
3D imaging can reveal more precisely the complexity of embryonic development in mice with viable solutions to genetic analysis of broadband to understand gene function.
Sept. 22, 2016
As part of the International Mouse Phenotyping Consortium, the French National Infrastructure for mouse phenogenomics, PHENOMIN hosted by the Mouse Clinical Institute (IGBMC, UMR7104 CNRS, INSERM, and University of Strasbourg) has coordinated its efforts with 17 other centers to reveal the important role of almost 1 out of 4 genes for controlling normal development of the mouse embryo. These results were published in Nature on September 22th.
Schematic drawing illustrating two intestinal epithelial cells (IEC) attached through α6β4 integrin to the basement membrane (BM), their specialized extracellular matrix (ECM). Loss of the integrin impairs epithelial integrity causing epithelium fragility and detachment from the BM. This cellular stress triggers an “alarm signal” in IECs (IL-18). Consequently, the mucus layer becomes altered, favoring bacterial translocation through the epithelial barrier and activation of the immune system. Infection and tissue injury then lead to a strong inflammation, mediated by the massive recruitment of innate immune cells and the secretion of IL-1β. With time, cells of the adaptive immunity sustain and perpetuate chronic inflammation, and ultimately induce the spontaneous development of cancer (CC, cancer cells).
Sept. 14, 2016
The work done by the team of Elisabeth Georges-Labouesse, with the help of Michel Labouesse at the IGBMC, has highlighted a novel and indispensable role for the extracellular matrix (ECM) which anchors cells, similar to foundations which support a house, in protecting the intestine against inflammation and secondary cancer development. These results provide new insights in the understanding of IBD and colitis-associated colorectal cancer and will help pave the way towards the development of novel therapies. This work was published on the 1st of July in the Journal Gut.