4 research departments
750 employees
45 nationalities
49 research teams
11 ERC laureates
250 publications per year
24000 m² lab area

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Fondation universite de Strasbourg
Mon, November 3rd - Fri, November 7th 2014

Cryo-Coupes et Immunomarquage

Tuesday, November 4th 2014 -

User group meeting NGS - RNA seq

Mon, November 24th - Wed, November 26th 2014

New strategies for macromolecular complexes analysis

Wed, November 26th - Fri, November 28th 2014

New strategies for macromolecular complexes analysis

Friday, October 31st 2014 - 2 p.m.
Dr Hugo Mouquet

Humoral Reponses to Pathogens: Learning from Human HIV-1 Antibodies

Wednesday, November 5th 2014 - 4 p.m.
Dr François Spitz

Managing long-distance (regulatory) relationships in development and disease

Wednesday, November 5th 2014 - 10 a.m.
Dr Christian M.T. Spahn

Structure and structural dynamics of functional ribosomal complexes

Prix Alexandre Joannidès 2014 Académie des sciences : Irwin DAVIDSON


IGBMC call for group leader positions in Functional Genomics & Cancer

Oct. 1, 2014

The Functional Genomics and Cancer (FGC) Department of IGBMC is recruiting new group leaders with support from the Laboratory of Excellence (LabEx) initiative.

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Imprimer Envoyer

A novel role for TAF4 in post-natal hepatocyte maturation

Upper panel: Section through a normal liver. The cell membranes are well delimited (in green) and normal bile ducts (BD) are formed.
Lower panel: Section through a liver lacking TAF4. The cell membranes are less well delimited (in green), and the bile ducts are defective (dBDs) and do not form a proper lumen to drain the bile from the liver.

Oct. 3, 2014

The group of Irwin Davidson have discovered a novel role for the TAF4 protein in hepatocyte maturation opening the way to understanding its eventual role in diabetes. The results are published by Alpern et al., on 3 October in eLife.

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Interplay of symmetry and asymmetry in a nuclear receptor

3D structure of the USP/EcR complex, bound to DNA (in blue) on the 5' end of palindromic response elements.

June 19, 2014

Recently installed in the new Centre for Integrative Biology of the IGBMC, the researchers of Bruno Klaholz’s team got interested in the nuclear receptor of ecdysone, an insect hormone, revealing its structure including the hormone and the DNA binding regions. These results, published on June 19th in the journal Nature Communications, highlight an unexpected asymmetry and provide new insights into the overall functioning of steroid receptors.

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SAGA: an underestimated role in the transcription of our genes

While the amount of total mRNA seemed little affected when SAGA is inhibited (bottom), the net production of new mRNA in the mutants is drastically reduced on all the genes (top).

Sept. 15, 2014

A study coordinated by Didier Devys in Làszlò Tora’s team at the IGBMC highlights the crucial role of the SAGA coactivator complex in the transcription of our genes, largely underestimated so far. Indeed they proved that it has a role throughout the entire transcribed genome and is essential for proper functioning of the RNA polymerase II. These results are published on September 15th in the journal Genes & Development.

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Inhibition of protein synthesis under the magnifying glass

Visualization of inhibitors binding sites on the two subunits of the eukaryotic ribosome. There are four main binding sites: the binding area of the messenger RNA, the decoding center, the E-site binding site of transfer RNA and the peptidyl transferase center.

Sept. 10, 2014

Protein biosynthesis is an essential for biological process that takes place in all living cells and is performed by the ribosomes. Understanding the highly complex structure of the ribosomes and their blocking agents is a challenge that have tried to meet for several years the teams of Marat Yusupov and Gulnara Yusupova at IGBMC. In their latest work published on September 10th in Nature, they reveal the high resolution structures of the eukaryotic ribosome, in complex with no less than 16 inhibitors, providing critical new data for the development of new drugs.

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Université de Strasbourg
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IGBMC - CNRS UMR 7104 - Inserm U 964
1 rue Laurent Fries / BP 10142 / 67404 Illkirch CEDEX / France Tél +33 (0)3 88 65 32 00 / Fax +33 (0)3 88 65 32 01 / directeur.igbmc@igbmc.fr