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Tuesday, April 22nd 2014 - 11 a.m.
Pr Yoshinori Watanabe

The inner centromere-shugoshin network prevents chromosomal instability

Monday, April 28th 2014 - 2 p.m.
Pr Reza Sharif Naeini

Contribution of mechanosensitive ion channels to osteoarthritis pain.

Tuesday, April 29th 2014 - 2 p.m.
Pr Christof Gebhardt

Single molecule imaging of transcription in the cell nucleus

International PhD Spring Call

is open until June 3rd 2014

Friedreich's ataxia – an effective gene therapy in an animal model

The illustrations show a measurement of the activity of a mitochondrial protein (in blue) essential for cellular energy production, which is impaired when frataxin is absent (no staining in the untreated heart). Using gene therapy expressing frataxin, the activity of this essential protein can be corrected across the heart's entire surface.

© Inserm / H. Puccio

April 6, 2014

The team led by Hélène Puccio, director of research for Inserm at the Institute of Genetics and Molecular and Cellular Biology (IGBMC) (Inserm / CNRS / University of Strasbourg) in close collaboration with Patrick Aubourg's team (Inserm and Professor of Neuropaediatrics at Bicêtre Hospital) has demonstrated, in the mice, the efficacy of gene therapy for treating the heart disease associated with Friedreich's ataxia, a rare hereditary neuro-degenerative disorder. The transfer, via a viral vector, of a normal copy of the gene deficient in patients, allowed to fully and very rapidly cure the heart disease in mice. These findings are published in Nature Medicine on 6 April, 2014.


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Brigitte Kieffer, laureate of L’Oréal-UNESCO For Women in Science Award

March 3, 2014

Every year since 1998, the UNESCO and L'Oréal Corporate Foundation rewards 5 women, one per continent, for their contribution to the advancement of Science and career in a field still largely dominated by men. For the 2014 awards, life sciences are being celebrated.


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Imprimer Envoyer

Histones hit the mark

Section of mouse testis tubules, location of sperm development.

During their maturation, spermatogenic cells move towards the tubule lumen. Importantly nucleosomes are destabilized in elongating spermatids (near the lumen) and replaced by other proteins allowing full condensation of the nucleus. The brown staining in the figure clearly reveals a high enrichment of H3K64Ac at this moment of sperm development.

March 25, 2014

The study of histones and their modifications is essential for the comprehension of gene expression. The group of Robert Schneider from the IGBMC discovered that one of these specific modifications, an acetylation, plays a role in the interaction histones/DNA. These results, published in the journal eLife, stress an implication of this histone mark in genome reorganization during the mouse sperm development and regulation of gene expression.

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