Prix jeune chercheur 2012 2013 Société de Biologie Cellulaire de France (SBCF) : Jacky GOETZ Prix scientifique 2013 Fondation Schlumberger pour l'Education et la Recherche (FSER) : Evi SOUTOGLOU Prix Lamonica de neurologie 2012 Académie des sciences : Brigitte KIEFFER
In healthy neurons, proteins DGCR8 and DROSHA are uniformly distributed in the nucleus. In neurons with FXTAS, these proteins are sequestered at CGG repeats within mRNA. © IGBMC
March 7, 2013
Nicolas Charlet-Berguerand’s team of the IGBMC has unveiled the physiopathological process of the FXTAS syndrome, a neurodegenerative disease of genetic origin concerning one person out of 4000. A study published March 7th, 2013 in Cell Reports.
Addition of an ubiquitin group on PLK1 kinase triggers its removal from the kinetochore and therefore allows stabilization of the kinetochore-microtubules attachments. © Nat. Cell Biol.
March 3, 2013
Izabela Sumara’s team at the IGBMC identified a new pathway regulating spatiotemporal distribution of PLK1 kinase, which is essential for mitotic progression. A study published on March 3rd, 2013 in Nat. Cell Biol.
The addition of an acetyl group on lysine 122 affects its interaction with DNA and thus promotes the eviction of the histone. The space created allows arrival of transcription proteins and thus expression of the gene.
Feb. 14, 2013
Discovering the mechanisms underlying gene expression is crucial to understand e.g. cell division, development or cancer formation. The team of Robert Schneider at the IGBMC has discovered a new mechanism that directly regulates the expression of genes. Their results are published on 14th of February in the journal Cell.
Frataxine role during the buildup of iron-sulfur cores. © Sandra Bour
Feb. 11, 2013
In partnership with two research groups from the CEA, Hélène Puccio’s team at the IGBMC unveiled the role of a protein called frataxin in the biosynthesis of iron-sulfur clusters. These results present a major advance in understanding the pathophysiology of Friedreich's Ataxia, a rare genetic disorder. A study published December 20th, 2012 in the Journal of the American Chemical Society.