IGBMC : Institut de la Génétique et de la Biologie Moléculaire et Cellulaire

• Researchers

  Daniel RIVELINE

• Post-Doctoral Fellows

  Alka BHAT

  Simon LO VECCHIO

• PhD Students

  Marie ANDRE

  Rémi BERTHOZ

  Tristan GUYOMAR

  Linjie LU

• Engineers & Technicians

  Michèle LIEB

Development and stem cells

Cell physics

Cells are traditionally viewed as a soup of chemical reactions. However cell shape is also the result of self-assembly phenomena; the physical laws of matter provide the appropriate framework for understanding shapes of cells and tissues. Within the cells, the cytoskeleton dynamics and its associated Rho pathways give the proper unit for understanding cell motility, cell division and cell shapes within tissues. We use interdisciplinary approaches to address these phenomena in cell culture. The physical framework is inspired from soft matter physics. The biological side is adapted from cell biology for changing specifically cell shapes with cytoskeleton drugs, genetic modifications, and mechanical constraints. The chemical part consists in designing new agents for altering cell motility and cell division. In the long term, our research may provide new ideas for understanding cancer.
Being interdisciplinary in nature, our group is located both at The Science and Supramolecular Engineering Institute in Strasbourg for the physical/chemical themes as well as at the IGBMC for those of cell biology. We use classical cell lines for fibroblasts and epithelium, along with fission yeast as a model system for cytokinesis. Microfabrication plays a key role for our measurements of forces, as well as for ordering cells in our experiments. A start-up, RingTech, is curently  incubated by Sémia, the alsatian incubator.

Team website

• Current projects

  As prototypes of organs derived in the lab from stem cells, organoids are a growing subject of study, with revolutionary perspectives in research and medicine.

   

  The prestigious Program Grant Award of the Human Frontier Science Program (HFSP) selected for funding the project carried out by Daniel Riveline, researcher at IGBMC, in international collaboration with three researchers (Alf Honigmann (Max Planck Institute, Dresden), Anne Grapin-Botton (Center for Stem Cell Biology, University of Copenhagen) and Masaki Sano (Dept. of Physics, The University of Tokyo)) to study the phenomena of cellular self-organization in organoids.

   

  This ambitious project aims to study the mechanisms of organoid formation. Using cellular models generating neuroepithelial and pancreatic structures, this research will aim to understand how these organs emerge from stem cells. It will involve over time and in close synergies several fields, cell physics, theoretical physics, cell biology, development biology, microfabrication and super-resolution microscopy.

• Collaborations

• Prizes/Awards

  • Daniel RIVELINE - Foundation Simone and Cino del Duca Prize - Institut de France de l'Académie des Sciences - 2011
  • Daniel RIVELINE - ATIP starting grant - CNRS - 2010
  • Daniel RIVELINE - Nine Choucroun Prize - Institut de Biologie Physico-Chimique de Paris - 1998

• News

  • July 1, 2016 - Cell division: how molecular motors team up for separating cells
  • Nov. 24, 2015 - Ratchetaxis: a new way how cells move
  • July 29, 2013 - New synthetic molecules target actin cytoskeleton

• Publications

  • Epithelial colonies in vitro elongate through collective effects.

    Comelles J, S SS, Lu L, Le-Maout E, Anvitha S, Salbreux G, Jülicher F, Inamdar MM, Riveline D

    Elife Jan. 4, 2021 ; 10: .

  • Collective Dynamics of Focal Adhesions Regulate Direction of Cell Motion.

    Lo Vecchio S, Thiagarajan R, Caballero D, Vigon V, Navoret L, Voituriez R, Riveline D

    Cell Syst June 24, 2020 ; 10:535-542.e4 .

  • Ratchetaxis in Channels: Entry Point and Local Asymmetry Set Cell Directions in Confinement.

    Le Maout E, Lo Vecchio S, Kumar Korla P, Jinn-Chyuan Sheu J, Riveline D

    Biophys J Oct. 6, 2020 ; 119:1301-1308 .

  • How to orient cells in microcavities for high resolution imaging of cytokinesis and lumen formation.

    Bhat A, Lu L, Wang CH, Lo Vecchio S, Maraspini R, Honigmann A, Riveline D

    Methods Cell Biol 2020 ; 158:25-41 .

  • Ends and middle: Global force balance and septum location in fission yeast.

    Le Goff X, Comelles J, Kervrann C, Riveline D

    Eur Phys J E Soft Matter May 29, 2020 ; 43:31 .

  • Generation of fluorescent cell-derived-matrix to study 3D cell migration.

    Godeau AL, Delanoë-Ayari H, Riveline D

    Methods Cell Biol 2020 ; 156:185-203 .

  • "Stochastic Resonance" for Individual Cells.

    Riveline D(1), Lo Vecchio S(2).

    Biophys J Feb. 4, 2020 ; 118:533-534 .

  • Directing cell migration on flat substrates and in confinement with microfabrication and microfluidics.

    Le Maout E(1), Lo Vecchio S(1), Bhat A(1), Riveline D(2).

    Methods Cell Biol 2018 ; 147:109-132 .

  • Active bundles of polar and bipolar filaments.

    Kreten FH(1), Hoffmann C(1), Riveline D(2), Kruse K(3).

    Phys Rev E Jul 2018 ; 98:012413 .

  • The Science of Living Matter for Tomorrow.

    Bauer G(1), Fakhri N(2), Kicheva A(3), Kondev J(4), Kruse K(5), Noji H(6), Riveline D(7), Saunders TE(8), Thattai M(9), Wieschaus E(10).

    Cell Syst April 25, 2018 ; 6:400-402 .

  See all publications=>

• Job opportunities

• Alumni

• Videos

• Thesis subjects

  • Interplay Between Signaling And Mechanics In Epithelia: Morphogenesis In Vitro (H/F)
  • Coupling Of Cell Polarization And Differentiation In Organoids (H/F)
  • Position Coupling Of Cell Polarization And Differentiation In Organoids (H/F)