The Team
  • Researchers

    Norbert GHYSELINCK

    Manuel MARK

    Cécile ROCHETTE-EGLY

    Marius TELETIN

    Nadège VERNET

  • PhD Students

    Sirine SOUALI-CRESPO

  • Engineers & Technicians

    Betty FERET

    Muriel KLOPFENSTEIN

    Régis LUTZING

Functional genomics and cancer

Retinoic acid signaling pathways driving stem spermatogonia ontogenesis and differentiation

Retinoic acid (RA), the biologically active metabolite of vitamin A, exerts a wide range of cellular effects by regulating proliferation, differentiation and apoptosis. At the cellular level, the action of RA is controlled through the modulated expression of cellular enzymes producing or degrading RA, retinaldehyde dehydrogenases (RALDH) or cytochrome P450 hydroxylases (CYP26), respectively. Then, acting in an hormone-like manner, RA binds to nuclear receptors (RAR) that function as transcriptional regulators through controlling, usually in the form of heterodimers with rexinoid receptors (RXR), the expression of RA target genes. Among the various tissues whose physiology depends upon vitamin A action, the seminiferous epithelium of the testis represents the most remarkable paradigm to investigate the pleiotropic effects of RA in vivo, as it integrates the problematic of stem cell renewal, cell proliferation, switching from mitotic to meiotic cell division, programmed cell death and paracrine signaling. Using a combination of innovative genetic, pharmacological and molecular approaches in the mouse, we are studying the cellular and molecular mechanisms that underlie the capabilities of RA to promote spermatogonia differentiation and beyond the differentiation of normal stem cells in vivo.

Imprimer Envoyer

Université de Strasbourg
INSERM
CNRS

IGBMC - CNRS UMR 7104 - Inserm U 1258
1 rue Laurent Fries / BP 10142 / 67404 Illkirch CEDEX / France Tél +33 (0)3 88 65 32 00 / Fax +33 (0)3 88 65 32 01 / directeur.igbmc@igbmc.fr