Functional genomics and cancer
Pathogenesis of inflammatory diseases
The conceptual focus of inflammatory diseases has shifted to epithelium (e.g. skin, airway and gut), which besides provides a physical barrier, also plays active roles in initiating and maintaining the inflammatory responses. Our studies from the last years have established the key role of epithelium-derived cytokine thymic stromal lymphopoietin (TSLP) in pathogenesis of atopic diseases including atopic dermatitis and asthma. Moreover, TSLP also emerges as a critical player widely implicated in various inflammatory pathologies, such as inflammatory bowel diseases, autoimmunity and cancer. The goals of our research are to investigate how TSLP expression is dysregulated in pathogenic contexts, to decode the complex cellular and molecular networks driven by TSLP in the inflammatory response, and to explore how such networks are implicated in pathogenesis of a variety of inflammatory diseases notably atopic diseases and cancer. To achieve these goals, we utilize integrated approaches of mouse genetic, pathophysiology-relevant mouse models, cellular and molecular biology, as well as systems biology. Based on the acquired knowledge, we also conduct collaborative studies with clinical researchers, with the ultimate goal to develop new biomarkers and therapeutic/prevention strategies for human inflammatory diseases.
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Current projects
• Investigating how TSLP expression is dysregulated in pathogenic contexts
• Decoding cellular and molecular networks driven by TSLP in the inflammatory response
• Exploring how TSLP-driven networks are implicated in pathogenesis of inflammatory diseases
• Translating the acquired knowledge into new biomarkers and therapeutic strategies for inflammatory diseases -
Collaborations
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Prizes/Awards
- Mei LI - Joint USIAS/FRIAS Fellowship 2013 - Institut d'études Avancées de l'Université de Strasbourg & Freiburg Institute for Advanced Studies - 2013
- Mei LI - Foundation Simone and Cino del Duca Prize - Institut de France - 2012
- Mei LI - Prix de la Société Française d'Allergologie - Société Française d'Allergologie - 2012
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News
- Jan. 24, 2019 - Mechanistic insight to a therapy of psoriasis
- March 15, 2016 - A breakthrough in understanding the mechanisms of inflammatory skin diseases
- Nov. 28, 2013 - Towards a better understanding of Th2 immune response in allergic diseases
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Publications
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The "Mast Cell and Basophil Club" of the French Society for Immunology.
Eur J Immunol Oct 2020 ; 50:1430-1431 .
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Cell Death Differ Jan 2020 ; 27:29-43 .
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JCI Insight Jan. 24, 2019 .
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Eur J Immunol May 2018 ; 48:861-873 .
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Experimental atopic dermatitis depends on IL-33R signaling via MyD88 in dendritic cells.
Cell Death Dis April 6, 2017 ; 8:e2735 .
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Proc Natl Acad Sci U S A Feb. 7, 2017 ; 114:E951-E960 .
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J Allergy Clin Immunol Jul 2016 ; 138:150-161 .
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Revue Française d'Allergologie 2014 2014 ; 54:364-376 .
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Eur Respir Rev Sep 2014 ; 23:292-8 .
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J Allergy Clin Immunol Oct 2014 ; 134:836-847 .
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Job opportunities
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Alumni
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Videos
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Thesis subjects