The Team
  • Researchers

    Sergey ALEKSEEV

    Frédéric COIN

    Emmanuel COMPE

    Jean-Marc EGLY

    Nicolas LE MAY

  • Post-Doctoral Fellowships

    Alexey EPANCHINTSEV

    Carlos Mario GENES ROBLES

    Zita NAGY

  • Phd Students

    Baptiste BIDON

    Federico COSTANZO

    Lise-Marie DONNIO

  • Engineers & Technicians

    Cathy BRAUN

    Philippe CATEZ

    Annabel LARNICOL

    Charlotte SAINT-ANDRE

  • Administrative Assistant

    Valérie GASSERT

  • Collaborateur Occasionnel

    Mariarita PERRI

Functional genomics and cancer

Genome expression and repair

Transcription, one of the key steps of gene expression in response to different stimuli of the organism like stress or hormones, requires a combination of factors. The deleterious action of physical or chemical agents that create lesions in the DNA disrupts the expression of genes. If these lesions are not removed by efficient repair systems they will be at the origin of mutations that can lead to cancer and aging. TFIIH, a multi-subunit complex that plays a pivotal role in both the transcription of genes and their repair. Mutations in some of the subunits of TFIIH are responsible for three genetic diseases (xeroderma pigmentosum (XP), trichotyodystrophy (TTD) and Cockayne syndrome (CS)), the phenotypes of which result from defects in both DNA repair and gene expression. For instance, TTD patients present brittle hairs and nails, that cannot account from a defect in DNA repair and that can be recapitulated in mouse TTD models. With the help of biochemical, genetic and cellular biology we study ageing and cancer predisposition in various cellular systems and animal models deficient in DNA repair and transcription processes.

 

Imprimer Envoyer

Université de Strasbourg
INSERM
CNRS

IGBMC - CNRS UMR 7104 - Inserm U 964
1 rue Laurent Fries / BP 10142 / 67404 Illkirch CEDEX / France Tél +33 (0)3 88 65 32 00 / Fax +33 (0)3 88 65 32 01 / directeur.igbmc@igbmc.fr