IGBMC : Institut de la Génétique et de la Biologie Moléculaire et Cellulaire

• Researchers

  Hinrich GRONEMEYER

  Marco Antonio MENDOZA PARRA

• Post-Doctoral Fellowships

  Valeria PAVET-PORTAL

  Maximiliano PORTAL

• Phd Students

  Pierre BORIES

  Valeriya MALYSHEVA

  Mohamed Ashick MOHAMED SALEEM

  Yelyzaveta SHLYAKHTINA

• Engineers & Technicians

  Benjamin BILLORE

  Matthias BLUM

  Pierre-Etienne CHOLLEY

  Cathie ERB

  Aurélie GODEL

  Michèle LIEB

Functional genomics and cancer

Systems biology of cell fate decisions in normal and tumor cells

Our interest is to understand the mechanisms and dynamics of signal transduction, epigenetic (de)regulation and chromatin structure, which coordinate global gene expression programs in normal and cancer cells. Based on our expertise on nuclear receptors action we develop technologies and global systems biology approaches to identify comprehensive RNA profiles, transcription factor binding sites, epigenomes and chromatin interactomes from ultra-small sample sizes, and use integrative bioinformatics to identify functional gene “hubs” and decision points that dynamically coordinate gene programming. Our studies involve a plethora of genome-wide technologies and the corresponding development of bioinformatics tools.

A particular interest of our team is the integrative analysis of aberrations affecting signaling, epigenome, chromatin architecture and transcriptome upon tumorigenic transformation. In this context we identify targets and mechanisms, which are relevant for the development of novel therapeutic paradigms, and study the mechanisms and therapeutic potential of signaling drugs and epigenetic modulators.

Another emphasis of our work is to decipher the mechanisms underlying the cancer-selectivity of apoptogenic TRAIL signaling. Studies on the role of the senescence-mediated secretome on TRAIL action and the epigenetic alterations during cellular senescence address the link between cancer and aging.

Team website

• Current projects

  - A multivalent peptide library approach to identify functional TRAIL mimetics, ApoMULTI-LIB. Project financed by the ANR
  - Molecular analysis of tumor-cell specific apoptosis. Project financed by the Ligue Nationale contre le cancer
  - HEALTH-F4-2007-200767 (APO-SYS) Apoptosis systems biology applied to cancer and AIDS. An integrated approach of experimental biology. Project financed by the European Commission
  - HEALTH-2007- 221952 (ATLAS) Development of Laser-Based Technologies and Prototype Instruments for Genome-Wide Chromatin ImmunoPrecipitation Analyses. Project financed by the European Commission
  - Decryption of the role(s) of methylated CBP/p300 species in signal transduction:  Analysis of methyl-HAT « codes » in differentiation and aberrant HAT methylation in cancer. Project financed by the INCa
  - Identification of modulators and gene expression signatures of TRAIL sensitivity. Project funded by ARC
  - Epigenetic regulation of tumour-cell specific apoptosis. Project financed by the INCa

• Collaborations

  - Dr. Angel de Lera, Professor of Organic Chemistry, Universidade de Vigo, Vigo, SPAIN
  - Dr. Laurence Vandel, Centre de Biologie du Developpement, UMR5547 du CNRS/Universite Paul Sabatier, Toulouse, FRANCE
  - Dr. William Bourguet, Centre de Biochimie Structurale, CNRS UMR5048 / INSERM U1054, Montpellier, France
  - Dr. Raoul Herbrecht, Hôpitaux Universitaires de Strasbourg, Strasbourg, France
  - Dr. Gilles Guichard, Institut Européen de Chimie et Biologie (IECB), Université de Bordeaux I - CNRS UMR 5248, Pessac, France
  - Dr. Sylvie Fournel, PhD, Institut de Biologie Moléculaire et Cellulaire, CNRS UPR 9021, Strasbourg, FRANCE
  - Olivier Micheau, INSERM  U866-Lipides Nutrition Cancer, Facultés de Médecine et de Pharmacie, Dijon, FRANCE
  
  ATLAS: http://www.atlas-eu.com/
  APO-SYS : http://www.apo-sys.eu/

• Prizes/Awards

  • Hinrich GRONEMEYER - Scientific Excellence Award - Inserm - 2010
  • Hinrich GRONEMEYER - European Medal - The Endocrine Society - 1996
  • Hinrich GRONEMEYER - Member of the European Molecular Biology Organization (EMBO) - European Molecular Biology Organization (EMBO) - 1995
  • Hinrich GRONEMEYER - Scientific Prize - Société Française d'Endocrinologie (SFE) - 1991

• News

  • Dec. 15, 2014 - Discovery of a novel RNA class
  • Nov. 24, 2014 - 2 IGBMC researchers among the world’s most influential
  • June 6, 2011 - Smaller and smaller samples
  • June 1, 2011 - The oestradiol secret code

• Publications

  • The inactive X chromosome is epigenetically unstable and transcriptionally labile in breast cancer.

    Chaligné R(1), Popova T(1), Mendoza-Parra MA(2), Saleem MA(2), Gentien D(1), Ban K(1), Piolot T(1), Leroy O(1), Mariani O(1), Gronemeyer H(2), Vincent-Salomon A(1), Stern MH(1), Heard E(3).

    Genome Res Feb. 4, 2015 .

  • Human cells contain natural double-stranded RNAs with potential regulatory functions.

    Portal MM(1), Pavet V(1), Erb C(1), Gronemeyer H(1).

    Nat Struct Mol Biol Jan 2015 ; 22:89-97 .

  • Thioether analogues of disulfide-bridged cyclic peptides targeting death receptor 5: conformational analysis, dimerisation and consequences for receptor activation.

    Pulka-Ziach K(1), Pavet V, Chekkat N, Estieu-Gionnet K, Rohac R, Lechner MC, Smulski CR, Zeder-Lutz G, Altschuh D, Gronemeyer H, Fournel S, Odaert B, Guichard G.

    Chembiochem Jan. 19, 2015 ; 16:293-301 .

  • Essential versus accessory aspects of cell death: recommendations of the NCCD 2015.

    Galluzzi L(1), Bravo-San Pedro JM(2), Vitale I(3), Aaronson SA(4), Abrams JM(5), Adam D(6), Alnemri ES(7), Altucci L(8), Andrews D(9), Annicchiarico-Petruzzelli M(10), Baehrecke EH(11), Bazan NG(12), Bertrand MJ(13), Bianchi K(14), Blagosklonny MV(15), Blomgren K(16), Borner C(17), Bredesen DE(18), Brenner C(19), Campanella M(20), Candi E(21), Cecconi F(22), Chan FK(23), Chandel NS(24), Cheng EH(25), Chipuk JE(4), Cidlowski JA(26), Ciechanover A(27), Dawson TM(28), Dawson VL(28), De Laurenzi V(29), De Maria R(3), Debatin KM(30), Di Daniele N(31), Dixit VM(32), Dynlacht BD(33), El-Deiry WS(34), Fimia GM(35), Flavell RA(36), Fulda S(37), Garrido C(38), Gougeon ML(39), Green DR(40), Gronemeyer H(41), Hajnoczky G(42), Hardwick JM(43), Hengartner MO(44), Ichijo H(45), Joseph B(46), Jost PJ(47), Kaufmann T(48), Kepp O(49), Klionsky DJ(50), Knight RA(51), Kumar S(52), Lemasters JJ(53), Levine B(54), Linkermann A(55), Lipton SA(56), Lockshin RA(57), López-Otín C(58), Lugli E(59), Madeo F(60), Malorni W(61), Marine JC(62), Martin SJ(63), Martinou JC(64), Medema JP(65), Meier P(66), Melino S(67), Mizushima N(68), Moll U(69), Muñoz-Pinedo C(70), Nuñez G(71), Oberst A(72), Panaretakis T(46), Penninger JM(73), Peter ME(74), Piacentini M(75), Pinton P(76), Prehn JH(77), Puthalakath H(78), Rabinovich GA(79), Ravichandran KS(80), Rizzuto R(81), Rodrigues CM(82), Rubinsztein DC(83), Rudel T(84), Shi Y(85), Simon HU(86), Stockwell BR(87), Szabadkai G(88), Tait SW(89), Tang HL(43), Tavernarakis N(90), Tsujimoto Y(91), Vanden Berghe T(13), Vandenabeele P(92), Villunger A(93), Wagner EF(94), Walczak H(95), White E(96), Wood WG(97), Yuan J(98), Zakeri Z(99), Zhivotovsky B(100), Melino G(101), Kroemer G(102).

    Cell Death Differ Jan 2015 ; 22:58-73 .

  • Integrative genomics to dissect retinoid functions.

    Mendoza-Parra MA(1), Gronemeyer H.

    Subcell Biochem 2014 ; 70:181-202 .

  • Dual RXR Agonists and RAR Antagonists Based on the Stilbene Retinoid Scaffold.

    Martínez C(1), Lieb M(2), Alvarez S(1), Rodríguez-Barrios F(1), Alvarez R(1), Khanwalkar H(2), Gronemeyer H(2), de Lera AR(1).

    ACS Med Chem Lett March 19, 2014 ; 5:533-537 .

  • Senescence-secreted factors activate Myc and sensitize pretransformed cells to TRAIL-induced apoptosis.

    Vjetrovic J(1), Shankaranarayanan P, Mendoza-Parra MA, Gronemeyer H.

    Aging Cell Jun 2014 ; 13:487-96 .

  • Plasminogen activator urokinase expression reveals TRAIL responsiveness and supports fractional survival of cancer cells.

    Pavet V(1), Shlyakhtina Y(1), He T(2), Ceschin DG(1), Kohonen P(2), Perälä M(2), Kallioniemi O(3), Gronemeyer H(1).

    Cell Death Dis Jan. 30, 2014 ; 5:e1043 .

  • Functions, therapeutic applications, and synthesis of retinoids and carotenoids.

    Alvarez R, Vaz B, Gronemeyer H, de Lera AR.

    Chem Rev Jan. 8, 2014 ; 114:1-125 .

  • Characterising ChIP-seq binding patterns by model-based peak shape deconvolution.

    Mendoza-Parra MA, Nowicka M, Van Gool W, Gronemeyer H.

    BMC Genomics Nov. 26, 2013 ; 14:834 .

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• Job opportunities

  • Systems Biology Of Osteoporotic Bone Disease (H/F)

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• Thesis subjects

  • Systems Biology Of Osteoporotic Bone Disease (H/F)