IGBMC : Institut de la Génétique et de la Biologie Moléculaire et Cellulaire

• Researchers

  Fabien ALPY

  Thien-Nga CHAMARAUX-TRAN

  Marie-Pierre CHENARD

  Nassim DALI YOUCEF

  Carole MATHELIN

  Catherine-Laure TOMASETTO

• Post-Doctoral Fellows

  Thomas DI MATTIA

• PhD Students

  Amélie JAULIN

  Arthur MARTINET

  Laetitia VOILQUIN

  Mehdi ZOUIOUICH

• Engineers & Technicians

  Corinne WENDLING

Functional genomics and cancer

Molecular and cellular biology of breast cancer

Breast cancer is a complex disease, with three main identified subtypes having different biological and clinical features and distinct responses to therapy. The next challenge in cancer management is to tailor breast cancer therapy to the individual patient. In this context, understanding the function of proteins altered in specific tumors and the relevance of their targeting is crucial. Our group identified in the past several important genes deregulated in cancer. The molecular and cellular characterization of these genes brought novel insights on the disease and we initiated original research themes.

One of our research focus is related to the characterization of the tumor microenvironment, especially to the function of the Metalloprotease 11 (MMP11) on metabolism and tumor cell-adipocyte crosstalk.

The second focus is on the StAR related lipid transfer domain 3 (STARD3) protein, a protein belonging to a family of lipid transporters. We showed that STARD3 moves cholesterol from the endoplasmic reticulum to endosomes by building protein complexes localized at membrane contact sites. We currently study how contact sites are formed and what roles they are playing in cancer.

Fabien Alpy is principal investigator in the team.

• Current projects

• Collaborations

• Prizes/Awards

  • Léa Wilhelm - Thesis Prize - GERLI - 2018
  • Thomas Di Mattia - Best presentation prize - Club endocytose exocytose - 2018
  • Léa Wilhelm - Doctoral Prize of the Doctoral School of Life and Health Sciences - Société de Biologie de Strasbourg - 2017
  • Thien-Nga CHAMARAUX-TRAN - Research contract - Société Française d’Anesthésie et de Réanimation - 2017
  • Adrien ROUSSEAU - Olga Sain/Comité de Paris - Conseil Scientifique de la ligue contre le cancer - 2017
  • Adrien ROUSSEAU - GERLI thesis prize - Groupe d'Etude et de Recherche en Lipidomique (GERLI) - 2014
  • Fabien ALPY - Les espoirs de l'Université de Strasbourg - Université de Strasbourg - 2014
  • Adrien ROUSSEAU - Thesis Prize of the the Doctoral School in Life and health sciences - Société de Biologie de Strasbourg - 2013
  • Elisabeth DAGUENET - Best Talk Award - Fondation Pierre-Gilles de Gennes - 2010
  • Elisabeth DAGUENET - Paul Basset Award - European Cancer Center (EuCC) - 2010
  • Aurélie BAGUET - Thesis Prize - Ecole Doctorale des Sciences de la Vie & de la Santé (UdS) - 2008
  • Catherine TOMASETTO - Scientific Prize - Comité Alsace de la Fondation pour la Recherche Médicale (FRM) - 2007
  • Catherine TOMASETTO - Paul Basset Award - European Cancer Center (EuCC) - 2004

• News

  • Sept. 13, 2018 - 2017, a year with the CNRS in Alsace
  • June 1, 2018 - Identification of MOSPD2, a novel molecular velcro bridging cellular organelles with the endoplasmic reticulum
  • April 4, 2017 - Alternative route for cholesterol
  • Dec. 3, 2013 - TRAF4 and membrane lipids orchestrate cancer cell migration

• Publications

  • The type 2 diabetes gene product STARD10 is a phosphoinositide binding protein that controls insulin secretory granule biogenesis.

    Carrat GR(1), Haythorne E(1), Tomas A(1), Haataja L(2), Müller A(3), Arvan P(2), Piunti A(4), Cheng K(5), Huang M(1), Pullen TJ(6), Georgiadou E(1), Stylianides T(7), Amirruddin NS(8), Salem V(9), Distaso W(10), Cakebread A(11), Heesom KJ(12), Lewis PA(12), Hodson DJ(13), Briant LJ(14), Fung ACH(15), Sessions RB(16), Alpy F(17), Kong APS(15), Benke PI(18), Torta F(18), Keong Teo AK(19), Leclerc I(1), Solimena M(3), Wigley DB(5), Rutter GA(20).

    Mol Metab May 13:101015 2020 .

  • [Breast cancer management during the COVID 19 pandemic: the CNGOF takes action].

    [Article in French]

    Gynecol Obstet Fertil Senol April 19, 2020 .

  • Another hijack! Some enteroviruses co-opt the c10orf76/PI4KB complex for their own good.

    Voilquin L(1)(2)(3)(4), Di Mattia T(1)(2)(3)(4), Alpy F(1)(2)(3)(4).

    EMBO Rep Jan 9:e49876 2020 .

  • Interleukin-32 Contributes to Human Nonalcoholic Fatty Liver Disease and Insulin Resistance.

    Dali-Youcef N(1)(2), Vix M(3), Costantino F(3), El-Saghire H(4), Lhermitte B(5), Callari C(3), D'Agostino J(3), Perretta S(3), Paveliu S(3), Gualtierotti M(3), Dumeny E(6), Oudot MA(4), Jaulin A(2), Dembele D(7), Zeisel MB(4), Tomasetto C(2), Baumert TF(4)(8), Doffoel M(8).

    Hepatol Commun July 19, 2019 ; 3:1205-1220 .

  • Probiotics Upregulate Trefoil Factors and Downregulate Pepsinogen in the Mouse Stomach.

    Khoder G(1), Al-Yassir F(2)(3), Al Menhali A(4), Saseedharan P(2), Sugathan S(2), Tomasetto C(5), Karam SM(6).

    Int J Mol Sci Aug. 10, 2019 .

  • An integrated genomic and metabolomic approach for defining survival time in adult oligodendrogliomas patients.

    Bund C(1)(2), Guergova-Kuras M(3), Cicek AE(4)(5), Moussallieh FM(6), Dali-Youcef N(7)(8), Piotto M(9), Schneider P(3), Heller R(10), Entz-Werle N(11), Lhermitte B(12), Chenard MP(12), Schott R(13), Proust F(14), Noel G(15), Namer IJ(6)(16)(17).

    Metabolomics April 29, 2019 ; 15:69 .

  • Increased expression of blood muscarinic receptors in patients with reflex syncope.

    Beutelstetter M(1)(2), Livolsi A(3), Greney H(4), Helms P(3), Schmidt-Mutter C(1)(2), De Melo C(5), Roul G(6), Zores F(7), Bolle A(1), Dali-Youcef N(8)(9), Beaugey M(4), Simon A(1), Niederhoffer N(4), Regnard J(10), Bouhaddi M(10), Adamopoulos C(3), Schaeffer M(11), Sauleau E(11), Bousquet P(1)(4).

    PLoS One July 18, 2019 ; 14:e0219598 .

  • Faraway, so close! Functions of Endoplasmic reticulum-Endosome contacts.

    Di Mattia T(1), Tomasetto C(2), Alpy F(3).

    Biochim Biophys Acta Mol Cell Biol Lipids June 25, 2019 .

  • [Too old for that? Only others believe it].

    Mathelin C(1), Nisand I(2).

    Gynecol Obstet Fertil Senol Jul-Aug 2019 ; 47:547-548 .

  • Effects of imidazoline-like drugs on liver and adipose tissues, and their role in preventing obesity and associated cardio-metabolic disorders.

    Aubertin G(1), Weiss M(1), Traversi F(1), Benameur D(1), Choquet P(2)(3), Dali-Youcef N(4)(5), Pons F(6), Sigrist S(7), Greney H(1), Monassier L(1), Bousquet P(1), Niederhoffer N(8).

    Int J Obes (Lond) March 29, 2019 .

  See all publications=>

• Job opportunities

• Alumni

• Videos

• Thesis subjects

  • Characterization Of Proteins Involved In A Newly Identified Er-Endosome Membrane Contact Site (H/F)