IGBMC : Institut de la Génétique et de la Biologie Moléculaire et Cellulaire

• Researchers

  Fabien ALPY

  Thien-Nga CHAMARAUX-TRAN

  Marie-Pierre CHENARD

  Nassim DALI YOUCEF

  Carole MATHELIN

  Catherine-Laure TOMASETTO

• Post-Doctoral Fellows

  Thomas DI MATTIA

  Laetitia VOILQUIN

• PhD Students

  Amélie JAULIN

  Arthur MARTINET

  Mehdi ZOUIOUICH

• Engineers & Technicians

  Corinne WENDLING

Functional genomics and cancer

Molecular and cellular biology of breast cancer

Breast cancer is a complex disease, with three main identified subtypes having different biological and clinical features and distinct responses to therapy. The next challenge in cancer management is to tailor breast cancer therapy to the individual patient. In this context, understanding the function of proteins altered in specific tumors and the relevance of their targeting is crucial. Our group identified in the past several important genes deregulated in cancer. The molecular and cellular characterization of these genes brought novel insights on the disease and we initiated original research themes.

One of our research focus is related to the characterization of the tumor microenvironment, especially to the function of the Metalloprotease 11 (MMP11) on metabolism and tumor cell-adipocyte crosstalk.

The second focus is on the StAR related lipid transfer domain 3 (STARD3) protein, a protein belonging to a family of lipid transporters. We showed that STARD3 moves cholesterol from the endoplasmic reticulum to endosomes by building protein complexes localized at membrane contact sites. We currently study how contact sites are formed and what roles they are playing in cancer.

Fabien Alpy is principal investigator in the team.

• Current projects

• Collaborations

• Prizes/Awards

  • Léa Wilhelm - Thesis Prize - GERLI - 2018
  • Thomas Di Mattia - Best presentation prize - Club endocytose exocytose - 2018
  • Léa Wilhelm - Doctoral Prize of the Doctoral School of Life and Health Sciences - Société de Biologie de Strasbourg - 2017
  • Thien-Nga CHAMARAUX-TRAN - Research contract - Société Française d’Anesthésie et de Réanimation - 2017
  • Adrien ROUSSEAU - Olga Sain/Comité de Paris - Conseil Scientifique de la ligue contre le cancer - 2017
  • Adrien ROUSSEAU - GERLI thesis prize - Groupe d'Etude et de Recherche en Lipidomique (GERLI) - 2014
  • Fabien ALPY - Les espoirs de l'Université de Strasbourg - Université de Strasbourg - 2014
  • Adrien ROUSSEAU - Thesis Prize of the the Doctoral School in Life and health sciences - Société de Biologie de Strasbourg - 2013
  • Elisabeth DAGUENET - Best Talk Award - Fondation Pierre-Gilles de Gennes - 2010
  • Elisabeth DAGUENET - Paul Basset Award - European Cancer Center (EuCC) - 2010
  • Aurélie BAGUET - Thesis Prize - Ecole Doctorale des Sciences de la Vie & de la Santé (UdS) - 2008
  • Catherine TOMASETTO - Scientific Prize - Comité Alsace de la Fondation pour la Recherche Médicale (FRM) - 2007
  • Catherine TOMASETTO - Paul Basset Award - European Cancer Center (EuCC) - 2004

• News

  • Sept. 13, 2018 - 2017, a year with the CNRS in Alsace
  • June 1, 2018 - Identification of MOSPD2, a novel molecular velcro bridging cellular organelles with the endoplasmic reticulum
  • April 4, 2017 - Alternative route for cholesterol
  • Dec. 3, 2013 - TRAF4 and membrane lipids orchestrate cancer cell migration

• Publications

  • Detection of Pneumocystis jirovecii in Patients with Severe COVID-19: Diagnostic and Therapeutic Challenges.

    Gerber V, Ruch Y, Chamaraux-Tran TN, Oulehri W, Schneider F, Lindner V, Greigert V, Denis J, Brunet J, Danion F

    J Fungi (Basel) July 22, 2021 ; 7: .

  • [Focus on axillary anatomy: The Carl Langer muscle, a great forgotten muscle in the training of medical residents in gynecology and obstetrics].

    Martel C, Cruchet C, Vibert F, Mathelin C

    Gynecol Obstet Fertil Senol June 29, 2021 ; : .

  • [Connected bras for breast cancer detection in 2021: Analysis and perspectives].

    Al Masry Z, Zerhouni N, Gay C, Meraghni S, Lodi M, Mathelin C, Devalland C

    Gynecol Obstet Fertil Senol June 4, 2021 ; : .

  • Coffee consumption and breast cancer risk: a narrative review in the general population and in different subtypes of breast cancer.

    Nehlig A, Reix N, Arbogast P, Mathelin C

    Eur J Nutr Apr 2021 ; 60:1197-1235 .

  • [The HRT follow-up consultation. What to do in case of breast pain. Postmenopausal women management: CNGOF and GEMVi clinical practice guidelines].

    Mathelin C

    Gynecol Obstet Fertil Senol May 2021 ; 49:493-499 .

  • [The HRT follow-up consultation. What to do in case of breast tumour (clinical or radiological) and microcalcifications. Postmenopausal women management: CNGOF and GEMVi clinical practice guidelines].

    Mathelin C, Molière S

    Gynecol Obstet Fertil Senol May 2021 ; 49:485-492 .

  • [Postmenopausal women management: CNGOF and GEMVi clinical practice guidelines (Short version)].

    Trémollieres F, Chabbert-Buffet N, Plu-Bureau G, Rousset-Jablonski C, Lecerf JM, Duclos M, Pouilles JM, Gosset A, Boutet G, Hocke C, Maris E, Hugon-Rodin J, Maitrot-Mantelet L, Robin G, André G, Hamdaoui N, Mathelin C, Lopes P, Graesslin O, Fritel X

    Gynecol Obstet Fertil Senol May 2021 ; 49:305-317 .

  • Impact of intravenous lidocaine on clinical outcomes of patients with ARDS during COVID-19 pandemia (LidoCovid): A structured summary of a study protocol for a randomised controlled trial.

    Muller M, Lefebvre F, Harlay ML, Glady L, Becker G, Muller C, Aberkane O, Tawk M, Julians M, Romoli A, Hecketsweiler S, Schneider F, Pottecher J, Chamaraux-Tran TN

    Trials Feb. 11, 2021 ; 22:131 .

  • 3D-printed simulator for nasopharyngeal swab collection for COVID-19.

    Sananès N, Lodi M, Koch A, Lecointre L, Sananès A, Lefebvre N, Debry C

    Eur Arch Otorhinolaryngol Jul 2021 ; 278:2649-2651 .

  • Narrative review of sentinel lymph node biopsy in breast cancer: a technique in constant evolution with still numerous unresolved questions.

    Mathelin C, Lodi M

    Chin Clin Oncol Apr 2021 ; 10:20 .

  See all publications=>

• Job opportunities

• Alumni

• Videos

• Thesis subjects