IGBMC : Institut de la Génétique et de la Biologie Moléculaire et Cellulaire

• Researchers

  Fabien ALPY

  Thien-Nga CHAMARAUX-TRAN

  Marie-Pierre CHENARD

  Nassim DALI YOUCEF

  Carole MATHELIN

  Catherine-Laure TOMASETTO

• Post-Doctoral Fellows

  Thomas DI MATTIA

  Laetitia VOILQUIN

• PhD Students

  Amélie JAULIN

  Arthur MARTINET

  Mehdi ZOUIOUICH

• Engineers & Technicians

  Corinne WENDLING

Functional genomics and cancer

Molecular and cellular biology of breast cancer

Breast cancer is a complex disease, with three main identified subtypes having different biological and clinical features and distinct responses to therapy. The next challenge in cancer management is to tailor breast cancer therapy to the individual patient. In this context, understanding the function of proteins altered in specific tumors and the relevance of their targeting is crucial. Our group identified in the past several important genes deregulated in cancer. The molecular and cellular characterization of these genes brought novel insights on the disease and we initiated original research themes.

One of our research focus is related to the characterization of the tumor microenvironment, especially to the function of the Metalloprotease 11 (MMP11) on metabolism and tumor cell-adipocyte crosstalk.

The second focus is on the StAR related lipid transfer domain 3 (STARD3) protein, a protein belonging to a family of lipid transporters. We showed that STARD3 moves cholesterol from the endoplasmic reticulum to endosomes by building protein complexes localized at membrane contact sites. We currently study how contact sites are formed and what roles they are playing in cancer.

Fabien Alpy is principal investigator in the team.

• Current projects

• Collaborations

• Prizes/Awards

  • Léa Wilhelm - Thesis Prize - GERLI - 2018
  • Thomas Di Mattia - Best presentation prize - Club endocytose exocytose - 2018
  • Léa Wilhelm - Doctoral Prize of the Doctoral School of Life and Health Sciences - Société de Biologie de Strasbourg - 2017
  • Thien-Nga CHAMARAUX-TRAN - Research contract - Société Française d’Anesthésie et de Réanimation - 2017
  • Adrien ROUSSEAU - Olga Sain/Comité de Paris - Conseil Scientifique de la ligue contre le cancer - 2017
  • Adrien ROUSSEAU - GERLI thesis prize - Groupe d'Etude et de Recherche en Lipidomique (GERLI) - 2014
  • Fabien ALPY - Les espoirs de l'Université de Strasbourg - Université de Strasbourg - 2014
  • Adrien ROUSSEAU - Thesis Prize of the the Doctoral School in Life and health sciences - Société de Biologie de Strasbourg - 2013
  • Elisabeth DAGUENET - Best Talk Award - Fondation Pierre-Gilles de Gennes - 2010
  • Elisabeth DAGUENET - Paul Basset Award - European Cancer Center (EuCC) - 2010
  • Aurélie BAGUET - Thesis Prize - Ecole Doctorale des Sciences de la Vie & de la Santé (UdS) - 2008
  • Catherine TOMASETTO - Scientific Prize - Comité Alsace de la Fondation pour la Recherche Médicale (FRM) - 2007
  • Catherine TOMASETTO - Paul Basset Award - European Cancer Center (EuCC) - 2004

• News

  • Sept. 13, 2018 - 2017, a year with the CNRS in Alsace
  • June 1, 2018 - Identification of MOSPD2, a novel molecular velcro bridging cellular organelles with the endoplasmic reticulum
  • April 4, 2017 - Alternative route for cholesterol
  • Dec. 3, 2013 - TRAF4 and membrane lipids orchestrate cancer cell migration

• Publications

  • Impact of intravenous lidocaine on clinical outcomes of patients with ARDS during COVID-19 pandemia (LidoCovid): A structured summary of a study protocol for a randomised controlled trial.

    Muller M, Lefebvre F, Harlay ML, Glady L, Becker G, Muller C, Aberkane O, Tawk M, Julians M, Romoli A, Hecketsweiler S, Schneider F, Pottecher J, Chamaraux-Tran TN

    Trials Feb. 11, 2021 ; 22:131 .

  • [Breast cancer management during the COVID 19 pandemic: the CNGOF takes action].

    Mathelin C, Nisand I

    Gynecol Obstet Fertil Senol April 18, 2020 ; : .

  • [ASIA syndrome associated with breast implants: Fortuitous link or association?].

    Cordel E, Reix N, Mathelin C

    Gynecol Obstet Fertil Senol Oct 2020 ; 48:754-762 .

  • [Impact of endocrine disrupting pesticides on breast cancer].

    Girard L, Reix N, Mathelin C

    Gynecol Obstet Fertil Senol Feb 2020 ; 48:187-195 .

  • 3D-printed simulator for nasopharyngeal swab collection for COVID-19.

    Sananès N, Lodi M, Koch A, Lecointre L, Sananès A, Lefebvre N, Debry C

    Eur Arch Otorhinolaryngol Nov. 6, 2020 ; :1-3 .

  • Narrative review of sentinel lymph node biopsy in breast cancer: a technique in constant evolution with still numerous unresolved questions.

    Mathelin C, Lodi M

    Chin Clin Oncol Dec. 18, 2020 ; : .

  • Diagnostic Accuracy and Clinical Impact of Sentinel Lymph Node Sampling in Endometrial Cancer at High Risk of Recurrence: A Meta-Analysis.

    Lecointre L, Lodi M, Faller É, Boisramé T, Agnus V, Baldauf JJ, Gallix B, Akladios C

    J Clin Med Nov. 28, 2020 ; 9: .

  • Matrix Metalloproteinase-11 Promotes Early Mouse Mammary Gland Tumor Growth through Metabolic Reprogramming and Increased IGF1/AKT/FoxO1 Signaling Pathway, Enhanced ER Stress and Alteration in Mitochondrial UPR.

    Tan B, Jaulin A, Bund C, Outilaft H, Wendling C, Chenard MP, Alpy F, Cicek AE, Namer IJ, Tomasetto C, Dali-Youcef N

    Cancers (Basel) Aug. 20, 2020 ; 12: .

  • FFAT motif phosphorylation controls formation and lipid transfer function of inter-organelle contacts.

    Di Mattia T, Martinet A, Ikhlef S, McEwen AG, Nominé Y, Wendling C, Poussin-Courmontagne P, Voilquin L, Eberling P, Ruffenach F, Cavarelli J, Slee J, Levine TP, Drin G, Tomasetto C, Alpy F

    EMBO J Dec. 1, 2020 ; 39:e104369 .

  • The type 2 diabetes gene product STARD10 is a phosphoinositide binding protein that controls insulin secretory granule biogenesis.

    Carrat GR(1), Haythorne E(1), Tomas A(1), Haataja L(2), Müller A(3), Arvan P(2), Piunti A(4), Cheng K(5), Huang M(1), Pullen TJ(6), Georgiadou E(1), Stylianides T(7), Amirruddin NS(8), Salem V(9), Distaso W(10), Cakebread A(11), Heesom KJ(12), Lewis PA(12), Hodson DJ(13), Briant LJ(14), Fung ACH(15), Sessions RB(16), Alpy F(17), Kong APS(15), Benke PI(18), Torta F(18), Keong Teo AK(19), Leclerc I(1), Solimena M(3), Wigley DB(5), Rutter GA(20).

    Mol Metab May 13:101015 2020 .

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• Job opportunities

• Alumni

• Videos

• Thesis subjects

  • Characterization Of Proteins Involved In A Newly Identified Er-Endosome Membrane Contact Site (H/F)