Immune and neural development
A major challenge in developmental biology is to understand how cell diversity is generated and how cells interact to build the sophisticated metazoan architecture. In humans, defects in such events lead to severe pathologies, from mental retardation to cancer. Evolutionary conservation, sophisticated genetics and simple organization make the fly an ideal tool to study these events in vivo and in vitro, at cellular resolution. The nervous system constitutes one of the most complex tissues, made of neurons and glia of different types. These cells arise from multipotent precursors or stem cells. The analysis of the signals controlling stem cell differentiation and reprogramming has recently drawn much attention, due to potential medical applications. Our goal is to study the molecular and the epigenetic events controlling cell differentiation and reprogramming. During development, many cells move as cohorts to attain their final destination and shape both tissues and organs. Distinct homeostatic cell interactions control directionality, coordination and integrity of the migratory unit. This dynamic event can hardly be tackled in vivo in large animals. We have developed a simple model to analyze the cellular and molecular features of this collective behavior.
Dr Catherine Bechade (IBENS, ENS, Paris)
Pr MariaPia Bozzetti (University of Lecce, Italy)
FMRP and RNA metabolism
Pr Andrea Brand (Gurdon Institute)
Gcm direct targets
Dr Giacomo Cavalli (IGH, Montpellier)
Polycomb and neural development
Dr Susan Chan (IGBMC)
Mouse immune system
Pr Cheng-Ting Chien (Academia Sinica, Taipei)
Protein degradation and development
Pr Gerard Karsenty (Columbia University, NY, USA)
Prs Veronica Rodriguez - VijayRaghavan (NCBS, Tata Institute of Fundamental Research Bangalore, India)
Collective glial migration
Pr José Alain Sahel & Dr Florian Sennlaub (Paris)
Pr Gerd Technau & Dr Ben Altenhein (Mainz, Germany)
Collective glial migration
Pr Marius Ueffing & Dr Ana Griciuc (U Munich, Germany)
- Angela GIANGRANDE - French-Taiwanese Foundation Scientific Prize - Institut de France de l'Académie des Sciences - 2009
- July 16, 2018 - Good relations between blood cells of different origins are crucial for an effective immune system
- Nov. 25, 2016 - A fly to better understand endometriosis
- July 28, 2014 - Neural stem cells: a finely controlled destiny
PLoS Genet Aug. 5, 2019 ; 15:e1007980 .
J Neurosci June 3, 2019 ; 39:5269-5283 .
Front Genet Feb. 13, 2019 ; 10:10 .
J Neurosci Jan. 9, 2019 ; 39:238-255 .
Haematologica Apr 2019 ; 104:717-728 .
Commun Biol June 7, 2018 ; 1:64 .
Elife July 11, 2018 ; 7:e34890 .
Whole transcriptome analysis of human erythropoietic cells during ontogenesis suggests a role of VEGFA gene as modulator of fetal hemoglobin and pharmacogenomic biomarker of treatment response to hydroxyurea in beta-type hemoglobinopathy patients.
Hum Genomics Oct. 23, 2017 ; 11:24 .
Dis Model Mech April 1, 2017 ; 10:463-474 .
Aquat Toxicol Apr 2016 ; 173:1-8 .
- Double colour time-lapse on a wt wing
- Fast cytoskeleton reorganisation in wing glia
- Front of migration on L1
- Glia-glia interactions control cell migration
- Glial proliferation and directional migration in the wing
- Glial proliferation followed by time-lapse. Time-lapse on repo-nlsGFP glial cells
- GPIId ablation
- GPIIp ablation
- Mis-oriented migration of supernumerary glia at posterior margin of Hw49c wings.