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A knock-in mouse model for KCNQ2-related epileptic encephalopathy displays spontaneous generalized seizures and cognitive impairment.
Milh M(1)(2), Roubertoux P(1), Biba N(3), Chavany J(1)(2), Spiga Ghata A(1), Fulachier C(1), Collins SC(4), Wagner C(4), Roux JC(1), Yalcin B(4), Félix MS(1), Molinari F(1)(3), Lenck-Santini PP(3), Villard L(1)(5).
Epilepsia April 2, 2020
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Aminobenzosuberone derivatives as PfA-M1 inhibitors: Molecular recognition and antiplasmodial evaluation.
Salomon E(1), Schmitt M(1), Mouray E(2), McEwen AG(3), Bounaadja L(2), Torchy M(3), Poussin-Courmontagne P(3), Alavi S(1), Tarnus C(1), Cavarelli J(3), Florent I(2), Albrecht S(4).
Bioorg Chem March 11, 2020
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A multifunnel energy landscape encodes the competing alpha-helix and beta-hairpin conformations for a designed peptide.
Chakraborty D, Chebaro Y, Wales DJ
Phys Chem Chem Phys Jan. 22, 2020
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A new glycogen storage disease caused by a dominant PYGM mutation.
Echaniz-Laguna A(1)(2)(3), Lornage X(4)(5)(6)(7), Laforêt P(8)(9), Orngreen MC(10), Edelweiss E(4)(5)(6)(7), Brochier G(11)(12), Bui MT(11), Silva-Rojas R(4)(5)(6)(7), Birck C(4)(5)(6)(7)(13), Lannes B(14), Romero NB(11)(12)(15), Vissing J(10), Laporte J(4)(5)(6)(7), Böhm J(4)(5)(6)(7).
Ann Neurol May 9, 2020
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An Integrated Analysis of miRNA and Gene Expression Changes in Response to an Obesogenic Diet to Explore the Impact of Transgenerational Supplementation with Omega 3 Fatty Acids.
Corral-Jara KF, Cantini L, Poupin N, Ye T, Rigaudière JP, De Saint Vincent S, Pinel A, Morio B, Capel F
Nutrients Dec. 17, 2020
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Another hijack! Some enteroviruses co-opt the c10orf76/PI4KB complex for their own good.
Voilquin L(1)(2)(3)(4), Di Mattia T(1)(2)(3)(4), Alpy F(1)(2)(3)(4).
EMBO Rep Jan 9:e49876 2020
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Antinociceptive Effects of Potent, Selective and Brain Penetrant Muscarinic M4 Positive Allosteric Modulators in Rodent Pain Models.
Grauer SM(1), Sanoja R(2), Poulin D(3), Rashid H(3), Jochnowitz N(4), Calhoun M(4), Zwilling D(4), Varty GB(4), Rosahl TW(4), Meziane H(5), Mittlelhaeuser C(5), Mazzola R(4), Morrow J(2), Smith SM(2), Henze D(2), Marcus J(2).
Brain Res Mar 29:146814 2020
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Aralar Sequesters GABA into Hyperactive Mitochondria, Causing Social Behavior Deficits.
Kanellopoulos AK(1), Mariano V(2), Spinazzi M(3), Woo YJ(4), McLean C(5), Pech U(6), Li KW(7), Armstrong JD(8), Giangrande A(9), Callaerts P(10), Smit AB(7), Abrahams BS(11), Fiala A(6), Achsel T(1), Bagni C(12).
Cell March 19, 2020
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